Detail Information

Basic Information:


  VIRBase ID:  

HHID00105017

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      RAD51-AS1:           IL6:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol RAD51-AS1 IL6
miRBase
Accession/Entrez ID		 100505648 3569
Organism Homo sapiens Homo sapiens
Category lncRNA mRNA
Alias TODRA BSF-2//BSF2//CDF//HGF//HSF//IFN-beta-2//IFNB2//IL-6

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt PMID
LincSNP 3.0 RAD51-AS1
rs2619683 chr15:40689145 C/G         17873874
rs5030783 chr15:40692191 C/T         20485568
rs1142468 chr15:40686528 C/T         20502693
rs2619679 chr15:40694039 A/T         21314694
rs2412545 chr15:40687453 C/T         23474282

RNA Editing:


Resource Symbol Editing Position
Lncediting RAD51-AS1
    chr15: 40983098
    chr15: 40983087
    chr15: 40983057
    chr15: 40983029
    chr15: 40983023
    chr15: 40983020
    chr15: 40983006
    chr15: 40983003
    chr15: 40982994
    chr15: 40982982
    chr15: 40982981
    chr15: 40982976
    chr15: 40982949
    chr15: 40982948
    chr15: 40982947
    chr15: 40982935
    chr15: 40982933
    chr15: 40982926
    chr15: 40982885
    chr15: 40982881
    chr15: 40982865
    chr15: 40982859
    chr15: 40982841
    chr15: 40982818
    chr15: 40982813
    chr15: 40982810
    chr15: 40982805
    chr15: 40982804
    chr15: 40982799
    chr15: 40982774
    chr15: 40982749
    chr15: 40982747
    chr15: 40981753
    chr15: 40980837
    chr15: 40980833
    chr15: 40980826
    chr15: 40980812
    chr15: 40980802
    chr15: 40980797
    chr15: 40980796
    chr15: 40980790
    chr15: 40980777
    chr15: 40980776
    chr15: 40980773
    chr15: 40986713
    chr15: 40986527
    chr15: 40986522
    chr15: 40980772
    chr15: 40980759
    chr15: 40980751
    chr15: 40980750
    chr15: 40980747
    chr15: 40980737
    chr15: 40980696
    chr15: 40980693
    chr15: 40980686
    chr15: 40980654
    chr15: 40980642
    chr15: 40980641
    chr15: 40980637
    chr15: 40980633
    chr15: 40980624
    chr15: 40980614
    chr15: 40980611
    chr15: 40980602
    chr15: 40986519
    chr15: 40986518
    chr15: 40986510
    chr15: 40986505
    chr15: 40986497
    chr15: 40986496
    chr15: 40986492
    chr15: 40986483
    chr15: 40986459
    chr15: 40986458
    chr15: 40986449
    chr15: 40986439
    chr15: 40986428
    chr15: 40986422
    chr15: 40986421
    chr15: 40986420
    chr15: 40986418
    chr15: 40986415
    chr15: 40986413
    chr15: 40986412
    chr15: 40986409
    chr15: 40986405
    chr15: 40986391
    chr15: 40986383
    chr15: 40986382
    chr15: 40986377
    chr15: 40986373
    chr15: 40986368
    chr15: 40986367
    chr15: 40986366
    chr15: 40986356
    chr15: 40986350
    chr15: 40986337
    chr15: 40986320
    chr15: 40986319
    chr15: 40986473
    chr15: 40986300
    chr15: 40986075
    chr15: 40986074
    chr15: 40986056
    chr15: 40986054
    chr15: 40986048
    chr15: 40986047
    chr15: 40986042
    chr15: 40986031
    chr15: 40986030
    chr15: 40986026
    chr15: 40985860
    chr15: 40985746
    chr15: 40985724
    chr15: 40985723
    chr15: 40986025
    chr15: 40986016
    chr15: 40986005
    chr15: 40986000
    chr15: 40985986
    chr15: 40985972
    chr15: 40985718
    chr15: 40985688
    chr15: 40985685
    chr15: 40985680
    chr15: 40983125
    chr15: 40985672
    chr15: 40985646
    chr15: 40985635
    chr15: 40985632
    chr15: 40985630
    chr15: 40985623
    chr15: 40985620
    chr15: 40985617
    chr15: 40985591
    chr15: 40985590
    chr15: 40985585
    chr15: 40985517
    chr15: 40985267
    chr15: 40985261
    chr15: 40985249
    chr15: 40985243
    chr15: 40985242
    chr15: 40985224
    chr15: 40985216
    chr15: 40985215
    chr15: 40985211
    chr15: 40985202
    chr15: 40985200
    chr15: 40985180
    chr15: 40985160
    chr15: 40985151
    chr15: 40985143
    chr15: 40985140
    chr15: 40985131
    chr15: 40985119
    chr15: 40985111
    chr15: 40985097
    chr15: 40985093
    chr15: 40985080
    chr15: 40985079
    chr15: 40985078
    chr15: 40985066
    chr15: 40985057
    chr15: 40985056
    chr15: 40985053
    chr15: 40985030
    chr15: 40985019
    chr15: 40985001
    chr15: 40984990
    chr15: 40984977
    chr15: 40984976
    chr15: 40984964
    chr15: 40984951
    chr15: 40984950
    chr15: 40984949
    chr15: 40984937
    chr15: 40983988
    chr15: 40983981
    chr15: 40983980
    chr15: 40983954
    chr15: 40983945
    chr15: 40983935
    chr15: 40983926
    chr15: 40983924
    chr15: 40983921
    chr15: 40983915
    chr15: 40983912
    chr15: 40983911
    chr15: 40983909
    chr15: 40983902
    chr15: 40983901
    chr15: 40983890
    chr15: 40983887
    chr15: 40983886
    chr15: 40985933
    chr15: 40985932
    chr15: 40985865
    chr15: 40983885
    chr15: 40983884
    chr15: 40983865
    chr15: 40983124
    chr15: 40983111
    chr15: 40983105
    chr15: 40983104
    chr15: 40983861
    chr15: 40983857
    chr15: 40983849
    chr15: 40983848
    chr15: 40983844
    chr15: 40983833
    chr15: 40983830
    chr15: 40983829
    chr15: 40983828
    chr15: 40983822
    chr15: 40983818
    chr15: 40983809
    chr15: 40983805
    chr15: 40983800
    chr15: 40983798
    chr15: 40983790
    chr15: 40983785
    chr15: 40983328
    chr15: 40983326
    chr15: 40983320
    chr15: 40983319
    chr15: 40983305
    chr15: 40983292
    chr15: 40983287
    chr15: 40983284
    chr15: 40983274
    chr15: 40983267
    chr15: 40983184
    chr15: 40983161
    chr15: 40983130
Resource Symbol Editing Position Change Genetic Region
RADAR IL6
chr7:22770700(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase RAD51-AS1
chr15:40978933-40978934(-) m6A exon       22608085
chr15:40978952-40978953(-) m6A exon       22608085
chr15:40978977-40978978(-) m6A exon       27773535//22608085
chr15:40979009-40979010(-) m6A exon       27773535//22608085
chr15:40979060-40979061(-) m6A exon       27773535//22608085
chr15:40979087-40979088(-) m6A exon       27773535//22608085
chr15:40979171-40979172(-) m6A exon       24284625//24981863//22608085
chr15:40979195-40979196(-) m6A exon       24284625//24981863//27773535//22608085
chr15:40979219-40979220(-) m6A exon       24981863//27773535//22608085
chr15:40979230-40979231(-) m6A exon       24981863//27773535//22608085
chr15:40979297-40979298(-) m6A exon       27773535
chr15:40979335-40979336(-) m6A exon       27773535
chr15:40986114-40986115(-) m6A exon//intron       24284625//27773535
chr15:40986177-40986178(-) m6A exon//intron       24284625//24981863//27773535
chr15:40986216-40986217(-) m6A exon//intron       24284625//27773535
chr15:40986263-40986264(-) m6A exon//intron       24284625//27773535
chr15:40986274-40986275(-) m6A exon//intron       24284625//27773535
chr15:40986604-40986605(-) m6A exon//intron       27773535
IL6
chr7:22766885-22766886(+) m6A 5'UTR//CDS//exon       -
chr7:22766928-22766929(+) m6A exon//intron       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate RAD51-AS1
Chromatin K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleus Ovarian cancer cell lines (HO8910|HO8910-PM|SKOV-3|SKOV3.ip)     28667302
Nucleus HeLa-S3 cells     -
IL6
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Serum     -
Nucleus HeLa-S3 cells     -
Polysome HeLa cells     26000482

Related Drug Information:


Resource Symbol Drug Name PubChem ID
RNAactDrug RAD51-AS1
Panobinostat       6918837
Dihydroartemisinyl ether, stereoisomer of NSC-685988       6712440
[(4E,6E,10E)-20,22-Dihydroxy-13,14,17-trimethoxy-4,8,10,12,16-pentamethyl-3-oxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18(22),19-hexaen-9-yl] carbamate       6438438
Pectenotoxin-1       6437860
l-685,458       5479543
Aspiculamycin hcl       54600418
Cytochalasin D       5458428
Hydrogeldanamycin-18,21-diacetate       5358471
Palbociclib       5330286
Imatinib       5291
Oxanosine       477547
9-beta-D-Xylofuranosyladenine       447916
(3S,8S,9R,10R,13R,14S,17R)-17-[(2R)-5,6-Dihydroxy-6-methylheptan-2-yl]-3-hydroxy-4,4,9,13,14-pentamethyl-1,2,3,7,8,10,12,15,16,17-decahydrocyclopenta[a]phenanthren-11-one       441813
Sangivamycin, 6-aminothio-       4033014
Bis(4-methylpiperazin-1-yl)methanethione       388906
4-Phenacyloxychromen-2-one       386272
2-[Bromo(iodo)methylidene]cyclohexan-1-one       376548
Ribavirin       37542
N-Hydroxy-N-methylpropanethioamide       371713
4-(1-Benzofuran-2-yl)-7-methoxychromen-2-one       364364
1-Naphthalenecarboxamide,N'-1,8-(octanediyl)bis-       364097
Paclitaxel       36314
3,5-Dimethyl-1-nitroso-2,6-diphenyl-4-piperidinone       362605
B676297K152 3',4'-Deoxypsorospermin       354176
Phomazarin       318385
2-Formylphenylboronic acid       292189
Gardenin A       261859
[(7R,13R,17R)-17-[2-[2-(Diethylamino)ethoxy]ethyl]-7,13-dimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl] sulfamate       24848393
Antibiotic U 29135       24196291
Propiophenone, 3-phenyl-3-piperidino-       219163
Sorafenib       216239
Sudan II       18386
N-(3-(1-Aziridinyl)propyl)-1,4-butanediamine       160394
5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120
Antineoplastic-633273       15954131
CID 13892272       13892272
Crizotinib       11626560
Nvp-aew541       11476171
1,1'-(benzo[d][1,3]dioxol-5-ylmethylene)dipiperazine       -
1,3,6-triphenyl-oxazolo(5,4-d)pyrimidin-2',4(1h,3h)-dion       -
;1,3-diphenyl-4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1...       -
;3-[(2E,4E)-4,6-dimethyl-1-oxo-2,4-octadien-1-yl]-1,4-di...       -
;3-amino-N-(3-(trifluoromethyl)phenyl)-6,7,8,9-tetrahydr...       -
;5-(5,6-dichloro-1H-benzo[d]imidazol-2-yl)-6-(4-fluoroph...       -
6-phenyl-6h-indeno[1,2-c]isoquinoline-5,11-dione       -
(8-8a),(8'-8'a)-tetradehydroisocalycanthine 3'a(r),3'a(r)       -
antineoplastic-625543       -
copper-elesclomol       -
;(E)-5-chloro-3-((6-(4-chlorophenyl)-2-cyclopropylimidaz...       -
;N-cyclohexyl-4-((1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4...       -
ptmc       -
;(Z)-6-Methoxy-2-(5-nitrothiophene-2-ylmethylene)-3(2H)-...       -
;(Z)-6-Methyl-2-(5-nitrofuran-2-ylmethylene)-3(2H)-benzo...       -
;(Z)-7-Methyl-2-(5-nitrofuran-2-ylmethylene)-3(2H)-benzo...       -

Interaction Network (The top 100 interactions):


Interactor1: RAD51-AS1
Interactor2: IL6

Evidence Support:


Prediction-Evidence LncRNA2Target
Support Database ViRBase

References:


PMID 33520952 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description We identified a total of 24 cytokine-lncRNA relationships using LncRNA2Target (Table 2). The most significant lncRNAs associated with COVID-19 cytokine storm cytokines, accompanied by lncRNA target prediction analysis using average ndG values.

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