Basic Information:

  VIRBase ID:  

HHID00105007

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      SBF2-AS1:  NR_036485          IL6:  NM_001318095     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	SBF2-AS1	IL6
miRBase Accession/Entrez ID	283104	3569
Organism	Homo sapiens	Homo sapiens
Category	lncRNA	mRNA
Alias	-	BSF-2//BSF2//CDF//HGF//HSF//IFN-beta-2//IFNB2//IL-6

RNA Editing:

Resource	Symbol	Editing Position
Lncediting	SBF2-AS1	chr11: 9831810     chr11: 9830831     chr11: 9830817     chr11: 9831811

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SBF2-AS1	chr11:9826642(+) A-I      intronic chr11:9826639(+) A-I      intronic chr11:9826616(+) A-I      intronic chr11:9826614(+) A-I      intronic chr11:9826613(+) A-I      intronic chr11:9826608(+) A-I      intronic chr11:9826606(+) A-I      intronic chr11:9831628(+) A-I      intronic chr11:9826615(+) A-I      intronic chr11:9828177(+) A-I      intronic chr11:9831661(+) A-I      intronic chr11:9831692(+) A-I      intronic chr11:9795157(+) A-I      intronic chr11:9826666(+) A-I      intronic chr11:9826643(+) A-I      intronic chr11:9831811(+) A-I      ncRNA chr11:9830817(+) A-I      ncRNA chr11:9830831(+) A-I      ncRNA chr11:9831810(+) A-I      ncRNA chr11:9831209(+) A-I      intronic chr11:9795014(+) A-I      intronic chr11:9782686(+) A-I      intronic chr11:9831645(+) A-I      intronic chr11:9831221(+) A-I      intronic chr11:9813764(+) A-I      intronic chr11:9831652(+) A-I      intronic chr11:9795078(+) A-I      intronic chr11:9831647(+) A-I      intronic chr11:9822141(+) A-I      intronic chr11:9831569(+) A-I      intronic chr11:9813807(+) A-I      intronic chr11:9831192(+) A-I      intronic chr11:9782676(+) A-I      intronic chr11:9831592(+) A-I      intronic chr11:9831117(+) A-I      intronic chr11:9822136(+) A-I      intronic chr11:9831574(+) A-I      intronic chr11:9815102(+) A-I      intronic chr11:9822093(+) A-I      intronic chr11:9821638(+) A-I      intronic chr11:9782828(+) A-I      intronic chr11:9831241(+) A-I      intronic chr11:9782829(+) A-I      intronic chr11:9831257(+) A-I      intronic chr11:9821629(+) A-I      intronic chr11:9831172(+) A-I      intronic chr11:9821623(+) A-I      intronic chr11:9831307(+) A-I      intronic chr11:9831166(+) A-I      intronic chr11:9821529(+) A-I      intronic chr11:9782842(+) A-I      intronic chr11:9831702(+) A-I      intronic chr11:9831568(+) A-I      intronic chr11:9831369(+) A-I      intronic chr11:9831131(+) A-I      intronic chr11:9831703(+) A-I      intronic chr11:9831367(+) A-I      intronic chr11:9831617(+) A-I      intronic chr11:9795114(+) A-I      intronic chr11:9831327(+) A-I      intronic chr11:9831273(+) A-I      intronic chr11:9831712(+) A-I      intronic chr11:9831302(+) A-I      intronic chr11:9831345(+) A-I      intronic chr11:9815146(+) A-I      intronic chr11:9831644(+) A-I      intronic chr11:9815117(+) A-I      intronic chr11:9831716(+) A-I      intronic chr11:9831725(+) A-I      intronic chr11:9831732(+) A-I      intronic chr11:9831764(+) A-I      intronic chr11:9831805(+) A-I      intronic chr11:9795122(+) A-I      intronic chr11:9831293(+) A-I      intronic chr11:9831156(+) A-I      intronic chr11:9831276(+) A-I      intronic chr11:9795130(+) A-I      intronic chr11:9831290(+) A-I      intronic chr11:9795134(+) A-I      intronic chr11:9831283(+) A-I      intronic chr11:9831680(+) A-I      intronic chr11:9831231(+) A-I      intronic chr11:9795068(+) A-I      intronic chr11:9795301(+) A-I      intronic
	IL6	chr7:22770700(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SBF2-AS1	chr11:9801399-9801400(+) m6A exon//intron       24284625//24209618//25456834//24981863//27773535//27371828//22608085 chr11:9801421-9801422(+) m6A exon//intron       24284625//24209618//25456834//24981863//27773535//27371828//22608085 chr11:9801441-9801442(+) m6A exon//intron       24284625//24209618//25456834//24981863//27773535//27371828//22608085 chr11:9801473-9801474(+) m6A exon//intron       24284625//24209618//25456834//24981863//27773535//27371828//22608085 chr11:9829566-9829567(+) m6A exon       24284625//24209618//24981863//22608085 chr11:9829577-9829578(+) m6A exon       24284625//24209618//24981863//22608085 chr11:9829588-9829589(+) m6A exon       24284625//24209618//24981863//22608085 chr11:9829718-9829719(+) m6A exon       24284625//24209618//24981863//22575960//22608085 chr11:9829840-9829841(+) m6A exon       24284625//24209618//24981863//22575960//22608085 chr11:9829895-9829896(+) m6A exon       24284625//24209618//24981863//22608085 chr11:9829909-9829910(+) m6A exon       24284625//24209618//24981863//22608085 chr11:9829959-9829960(+) m6A exon       24284625//24209618//22608085 chr11:9830085-9830086(+) m6A exon       24284625//24981863//22608085 chr11:9830144-9830145(+) m6A exon       24981863//22608085 chr11:9830153-9830154(+) m6A exon       24981863//22608085 chr11:9830477-9830478(+) m6A exon       22608085 chr11:9830487-9830488(+) m6A exon       22608085 chr11:9830495-9830496(+) m6A exon       22608085 chr11:9830556-9830557(+) m6A exon       24981863//22608085 chr11:9830568-9830569(+) m6A exon       24981863//22608085 chr11:9830578-9830579(+) m6A exon       24981863//22608085 chr11:9830669-9830670(+) m6A exon       24284625//24981863//22608085 chr11:9830716-9830717(+) m6A exon       24284625//24209618//25456834//24981863//22608085 chr11:9830813-9830814(+) m6A exon       24981863//22608085 chr11:9831812-9831813(+) m6A exon       24981863//22608085 chr11:9832624-9832625(+) m6A exon       22608085 chr11:9832643-9832644(+) m6A exon       22608085 chr11:9832682-9832683(+) m6A exon       24981863//22608085 chr11:9832699-9832700(+) m6A exon       24981863//22608085 chr11:9832769-9832770(+) m6A exon       24981863
	IL6	chr7:22766885-22766886(+) m6A 5'UTR//CDS//exon       - chr7:22766928-22766929(+) m6A exon//intron       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	SBF2-AS1	Cytosol HCC cell line (HepG2)     - Exosome Blood     - Membrane K562 cells     - Ribosome-free cytosol Colon cancer cells     24393600
	IL6	Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Serum     - Nucleus HeLa-S3 cells     - Polysome HeLa cells     26000482

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	SBF2-AS1	Monoanhydride with sulfuric acid       5351242 Myricoside       5281784 2-(Chloromethyl)-6-hydroxy-1-(methylsulphonyl)-indoline       384835 23-(Dimethylamino)-4,8,22,24-tetrahydroxy-1,12-dimethyl-20,25-dioxahexacyclo[19.3.1.02,19.05,18.07,16.09,14]pentacosa-2,4,7(16),8,10,12,14,18-octaene-6,17-dione       3751252 Nutlin-3       216345 (S)-N-((S)-1-Cyclohexyl-2-oxo-2-((3aR,7aS)-6-phenethyloctahydro-1H-pyrrolo[2,3-c]pyridin-1-yl)ethyl)-2-(methylamino)propanamide       11503417 1-bromo-2-bromomethyl-o-carborane       - 8,8'-(3,3'-dimethoxybenzyl)-8-hydroxy-butyrolacton       - 9,19-cycloart-23-ene-3.beta.,25-diol       - b 80568       - formamide, n-[4-(3,3-dimethyl-1-triazenyl)phenyl]-       -

Interaction Network (The top 100 interactions):

Interactor1: SBF2-AS1
Interactor2: IL6

Evidence Support:

Prediction-Evidence	LncRNA2Target
Support Database	ViRBase

References:

PMID	33520952	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	We identified a total of 24 cytokine-lncRNA relationships using LncRNA2Target (Table 2). The most significant lncRNAs associated with COVID-19 cytokine storm cytokines, accompanied by lncRNA target prediction analysis using average ndG values.