Detail Information

Basic Information:


  VIRBase ID:  

HHID00098091

  Virus:  

Vesicular stomatitis virus (VSV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8589

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-29b-3p:           TNF:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-29b-3p TNF
miRBase
Accession/Entrez ID		 MIMAT0000100 7124
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - DIF//TNF-alpha//TNFA//TNFSF2//TNLG1F

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-29b-3p
rs868994683 chr7:130877473    G/A
rs1390817128 chr1:207802451    A/G
rs773555186 chr1:207802453    A/C
rs773555186 chr1:207802453    A/T

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TNF
chr6:31543363-31543364(+) m6A 5'UTR       -
chr6:31543373-31543374(+) m6A 5'UTR       -
chr6:31543403-31543404(+) m6A 5'UTR       -
chr6:31543416-31543417(+) m6A 5'UTR       -
chr6:31543513-31543514(+) m6A 5'UTR       -
chr6:31545104-31545105(+) m6A CDS       26404942
chr6:31545152-31545153(+) m6A CDS       26404942
chr6:31545323-31545324(+) m6A 3'UTR       26404942
chr6:31545382-31545383(+) m6A 3'UTR       26404942
chr6:31545434-31545435(+) m6A 3'UTR       26404942
chr6:31545447-31545448(+) m6A 3'UTR       26404942
chr6:31545462-31545463(+) m6A 3'UTR       26404942
chr6:31545476-31545477(+) m6A 3'UTR       26404942
chr6:31545537-31545538(+) m6A 3'UTR       26404942
chr6:31545552-31545553(+) m6A 3'UTR       26404942
chr6:31545599-31545600(+) m6A 3'UTR       26404942
chr6:31545636-31545637(+) m6A 3'UTR       26404942
chr6:31545646-31545647(+) m6A 3'UTR       26404942
chr6:31545673-31545674(+) m6A 3'UTR       26404942
chr6:31545706-31545707(+) m6A 3'UTR       26404942
chr6:31545717-31545718(+) m6A 3'UTR       26404942
chr6:31545833-31545834(+) m6A 3'UTR       26404942
chr6:31545851-31545852(+) m6A 3'UTR       26404942
chr6:31545879-31545880(+) m6A 3'UTR       26404942
chr6:31545906-31545907(+) m6A 3'UTR       26404942

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-29b-3p
Cytoplasm HeLa cells     28185889
Cytoplasm Hepatic carcinoma cells (Huh-7)     29253196
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Urine     26576778
Exosome HCC tissues     30542726
Exosome Saliva     19627513
Exosome B cell line (Raji)|Primary dendritic cells|T cell line (J77)     21505438
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Breast milk|Epithelial cells|Seminal fluid|Tongue tissue     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Hela cells|NIH-3T3 cells     17204650
Nucleus HeLa cells     28185889
Nucleus Hepatic carcinoma cells (Huh-7)     29253196
Nucleus HeLa cells     30006350
Nucleus Nasopharyngeal carcinoma cells     20498841
TNF
Exosome Blood     -
Polysome HeLa cells     26000482

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-29b-3p
Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug resistant
Phenyl gallate 333279 Drug resistant
N-[(4R)-4-[(3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Tris(3-aminopropoxy)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentyl]octan-1-amine 24205348 Drug sensitive
8-Hydroxyquinoline 1923 Drug resistant
(R)-(2,8-Bis(trifluoromethyl)quinolin-4-yl)((S)-piperidin-2-yl)methanol hydrochloride 18660697 Drug sensitive
Acid Alizarine Red B 135565636 Drug resistant
2-Acetylimidazo[4,5-b]pyridin 4 tolyl 3 thiosemicarbazone 135440014 Drug resistant
1,8-octanediamine, n,n'-di-9-acridinyl- (9ci) - Drug resistant
4-carbo-1-thiazolidine-3-o-gluconyl-.gamma.-lactone - Drug resistant
naphth[2,3-d]oxazol-9-one, 2-methyl-4-(phenylimino)- - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-29b-3p
Formaldehyde 712 Drug interaction    RC00001120
Oxaliplatine 6857599 Drug interaction    RC00001140
Gemcitabine 60750 Drug interaction    RC00001131
Progesterone 5994 Drug interaction    RC00001126
D-Glucose 5793 Drug interaction    RC00001125
Eloxatine 5310940 Drug interaction    RC00001139
Imatinib 5291 Drug interaction    RC00001124
Decitabine 451668 Drug interaction    RC00001137
Docosahexaenoic acid 445580 Drug interaction    RC00001136
Trichostatin A 444732 Drug interaction    RC00001135
Cyclopamine 442972 Drug interaction    RC00001134
Bortezomib 387447 Drug interaction    RC00001133
Etoposide 36462 Drug interaction    RC00001130
Paclitaxel 36314 Drug interaction    RC00001129
5-Fluorouracil 3385 Drug interaction    RC00001123
Enoxacin 3229 Drug interaction    RC00001122
Doxorubicin 31703 Drug interaction    RC00001128
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001121
Tamoxifen 2733526 Drug interaction    RC00001138
Ixazomib 25183872 Drug interaction    RC00001144
Navitoclax 24978538 Drug interaction    RC00001143
Ampligen & InterferonalphaA 16197265 Drug interaction    RC00001142
Leucovorin 135403648 Drug interaction    RC00001145
Ginsenoside Rh2 119307 Drug interaction    RC00001132
Carfilzomib 11556711 Drug interaction    RC00001141
Androstanolone 10635 Drug interaction    RC00001127
Chemotherapy - Drug interaction    RC00001146
5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) - Drug interaction    RC00001147
Glucocorticoid - Drug interaction    RC00001148
Testosterone + 1,25-Dihydroxyvitamin D3 - Drug interaction    RC00001149
Trastuzumab - Drug interaction    RC00001150
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-29b-3p
Bortezomib 387447       30728351

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-29b-3p
Interactor2: TNF

Evidence Support:


Strong-Evidence RT-PCR
Weak-Evidence Microarray
Support Database VIRmiRNA

References:


PMID 22676898 Target region None
Source VIRmiRNA Interactor1 expression None
Tissue or cell line NIH3T3 cells Interactor2 expression None
Description As a possible candidate for antiviral activity, salivary microvesicles contain at least 20 miRNAs, small noncoding RNAs, which suppress the translation of target mRNAs [9]. List of the most highly expressed human microRNAs in salivary microvesicles are: hsa-let-7b, hsa-let-7c*, hsa-miR-128, hsa-miR-150*, hsa-miR-17, hsa-miR-1908, hsa-miR-212, hsa-miR-27b*, hsa-miR-29b, hsa-miR-29c, hsa-miR-335, hsa-miR-379*, hsa-miR-433, hsa-miR-454, hsa-miR-483-3p, hsa-miR-584, hsa-miR-621, hsa-miR-652, hsa-miR-760 and hsa-miR-888* [9]. More recently, it was shown that salivary microvesicles also contain GW182, which is required for miRNA function [10].

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