Basic Information:

  VIRBase ID:  

HHID00096600

  Virus:  

Human immunodeficiency virus 1 (HIV-1)

  Host:  

Homo sapiens

  Confidence Score:  

0.9489

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-let-7g-3p:  MIMAT0004584          IL10:  NR_168467     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-let-7g-3p	IL10
miRBase Accession/Entrez ID	MIMAT0004584	3586
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CSIF//GVHDS//IL-10//IL10A//TGIF

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-let-7g-3p	rs1022640944 chr3:52268290    G/A rs1166657040 chr3:52268299    A/G rs1356748432 chr3:52268293    C/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	IL10	chr1:206941331(-) A-I      3'UTR

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-let-7g-3p	Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Serum     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cerebrospinal fluid     24797360 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -
	IL10	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-let-7g-3p
Interactor2: IL10

Evidence Support:

Strong-Evidence	Luciferase reporter assay//RT-PCR
Weak-Evidence	Microarray
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

[1]PMID	22586040	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HeLa cells//HUT78 cells	Interactor2 expression	Downregulation
Description	Our initial in vitro studies demonstrated that HIV-1-infected HUT78 cells expressed significantly higher IL-10 levels compared with uninfected cultures. IL-10 plays an important role in the dysregulated cytotoxic T cell response to HIV-1, and in silico algorithms suggested that let-7 miRNAs target IL10 mRNA.

[2]PMID	22936931	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HeLa cells//HUT78 cells	Interactor2 expression	Downregulation
Description	Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions.Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products.