Basic Information:

  VIRBase ID:  

HHID00096599

  Virus:  

Human immunodeficiency virus 1 (HIV-1)

  Host:  

Homo sapiens

  Confidence Score:  

0.9926

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-223-5p:  MIMAT0004570          CCNT1:  NM_001277842     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-223-5p	CCNT1
miRBase Accession/Entrez ID	MIMAT0004570	904
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CCNT//CYCT1//HIVE1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-223-5p	rs1240009384 chrX:66018913    A/T rs1397275461 chrX:66018904    G/T rs1464475149 chrX:66018916    T/C rs761701581 chrX:66018906    C/G rs772305537 chrX:66018909    G/A rs774279244 chrX:66018895    C/T rs890919635 chrX:66018896    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CCNT1	chr12:49090783(-) A-I      intronic chr12:49090835(-) A-I      intronic chr12:49090772(-) A-I      intronic chr12:49090712(-) A-I      intronic chr12:49091140(-) A-I      intronic chr12:49091038(-) A-I      intronic chr12:49095899(-) A-I      intronic chr12:49090821(-) A-I      intronic chr12:49095859(-) A-I      intronic chr12:49095850(-) A-I      intronic chr12:49090818(-) A-I      intronic chr12:49107970(-) A-I      intronic chr12:49107949(-) A-I      intronic chr12:49107909(-) A-I      intronic chr12:49090794(-) A-I      intronic chr12:49106697(-) A-I      intronic chr12:49106506(-) A-I      intronic chr12:49105806(-) A-I      intronic chr12:49105782(-) A-I      intronic chr12:49105780(-) A-I      intronic chr12:49105714(-) A-I      intronic chr12:49105668(-) A-I      intronic chr12:49105681(-) A-I      intronic chr12:49105111(-) A-I      intronic chr12:49105106(-) A-I      intronic chr12:49105023(-) A-I      intronic chr12:49105006(-) A-I      intronic chr12:49105000(-) A-I      intronic chr12:49104838(-) A-I      intronic chr12:49104700(-) A-I      intronic chr12:49103842(-) A-I      intronic chr12:49103726(-) A-I      intronic chr12:49105141(-) A-I      intronic chr12:49102756(-) A-I      intronic chr12:49101330(-) A-I      intronic chr12:49099023(-) A-I      intronic chr12:49098509(-) A-I      intronic chr12:49098480(-) A-I      intronic chr12:49098409(-) A-I      intronic chr12:49097474(-) A-I      intronic chr12:49096624(-) A-I      intronic chr12:49096419(-) A-I      intronic chr12:49103034(-) A-I      intronic chr12:49095752(-) A-I      intronic chr12:49095727(-) A-I      intronic chr12:49090795(-) A-I      intronic chr12:49095721(-) A-I      intronic chr12:49090771(-) A-I      intronic chr12:49095718(-) A-I      intronic chr12:49095571(-) A-I      intronic chr12:49096402(-) A-I      intronic chr12:49096578(-) A-I      intronic chr12:49095443(-) A-I      intronic chr12:49096394(-) A-I      intronic chr12:49091545(-) A-I      intronic chr12:49096383(-) A-I      intronic chr12:49103741(-) A-I      intronic chr12:49107364(-) A-I      intronic chr12:49099350(-) A-I      intronic chr12:49102803(-) A-I      intronic chr12:49107400(-) A-I      intronic chr12:49099288(-) A-I      intronic chr12:49107969(-) A-I      intronic chr12:49100769(-) A-I      intronic chr12:49091098(-) A-I      intronic chr12:49103819(-) A-I      intronic chr12:49106104(-) A-I      intronic chr12:49096788(-) A-I      intronic chr12:49091223(-) A-I      intronic chr12:49104681(-) A-I      intronic chr12:49090777(-) A-I      intronic chr12:49091555(-) A-I      intronic chr12:49090681(-) A-I      intronic chr12:49099255(-) A-I      intronic chr12:49096760(-) A-I      intronic chr12:49107321(-) A-I      intronic chr12:49090754(-) A-I      intronic chr12:49090789(-) A-I      intronic chr12:49105087(-) A-I      intronic chr12:49090792(-) A-I      intronic chr12:49102669(-) A-I      intronic chr12:49099268(-) A-I      intronic chr12:49104991(-) A-I      intronic chr12:49102798(-) A-I      intronic chr12:49099335(-) A-I      intronic chr12:49090751(-) A-I      intronic chr12:49104687(-) A-I      intronic chr12:49096724(-) A-I      intronic chr12:49091046(-) A-I      intronic chr12:49099275(-) A-I      intronic chr12:49101344(-) A-I      intronic chr12:49107533(-) A-I      intronic chr12:49106166(-) A-I      intronic chr12:49103813(-) A-I      intronic chr12:49090701(-) A-I      intronic chr12:49107499(-) A-I      intronic chr12:49090796(-) A-I      intronic chr12:49101815(-) A-I      intronic chr12:49095621(-) A-I      intronic chr12:49096721(-) A-I      intronic chr12:49102813(-) A-I      intronic chr12:49091533(-) A-I      intronic chr12:49090799(-) A-I      intronic chr12:49107498(-) A-I      intronic chr12:49095952(-) A-I      intronic chr12:49107422(-) A-I      intronic chr12:49095858(-) A-I      intronic chr12:49106601(-) A-I      intronic chr12:49090688(-) A-I      intronic chr12:49106228(-) A-I      intronic chr12:49106306(-) A-I      intronic chr12:49097462(-) A-I      intronic chr12:49097659(-) A-I      intronic chr12:49097668(-) A-I      intronic chr12:49091553(-) A-I      intronic chr12:49105628(-) A-I      intronic chr12:49107910(-) A-I      intronic chr12:49090810(-) A-I      intronic chr12:49097488(-) A-I      intronic chr12:49101267(-) A-I      intronic chr12:49095476(-) A-I      intronic chr12:49090744(-) A-I      intronic chr12:49090829(-) A-I      intronic chr12:49091099(-) A-I      intronic chr12:49090830(-) A-I      intronic chr12:49095463(-) A-I      intronic chr12:49095817(-) A-I      intronic chr12:49107745(-) A-I      intronic chr12:49101342(-) A-I      intronic chr12:49106230(-) A-I      intronic chr12:49107090(-) A-I      intronic chr12:49105062(-) A-I      intronic chr12:49091137(-) A-I      intronic chr12:49103770(-) A-I      intronic chr12:49090793(-) A-I      intronic chr12:49090854(-) A-I      intronic chr12:49104809(-) A-I      intronic chr12:49099329(-) A-I      intronic chr12:49106196(-) A-I      intronic chr12:49091414(-) A-I      intronic chr12:49091186(-) A-I      intronic chr12:49107788(-) A-I      intronic chr12:49091100(-) A-I      intronic chr12:49091436(-) A-I      intronic chr12:49095975(-) A-I      intronic chr12:49096652(-) A-I      intronic chr12:49096658(-) A-I      intronic chr12:49105608(-) A-I      intronic chr12:49107375(-) A-I      intronic chr12:49090708(-) A-I      intronic chr12:49107323(-) A-I      intronic chr12:49091304(-) A-I      intronic chr12:49096517(-) A-I      intronic chr12:49103956(-) A-I      intronic chr12:49095898(-) A-I      intronic chr12:49090721(-) A-I      intronic chr12:49090785(-) A-I      intronic chr12:49090287(-) A-I      intronic chr12:49101678(-) A-I      intronic chr12:49095592(-) A-I      intronic chr12:49107349(-) A-I      intronic chr12:49107890(-) A-I      intronic chr12:49106197(-) A-I      intronic chr12:49106684(-) A-I      intronic chr12:49097304(-) A-I      intronic chr12:49106244(-) A-I      intronic chr12:49097597(-) A-I      intronic chr12:49105149(-) A-I      intronic chr12:49095486(-) A-I      intronic chr12:49091439(-) A-I      intronic chr12:49107357(-) A-I      intronic chr12:49096548(-) A-I      intronic chr12:49098583(-) A-I      intronic chr12:49090820(-) A-I      intronic chr12:49106183(-) A-I      intronic chr12:49090849(-) A-I      intronic chr12:49105063(-) A-I      intronic chr12:49091526(-) A-I      intronic chr12:49101298(-) A-I      intronic chr12:49098404(-) A-I      intronic chr12:49088642(-) A-I      intronic chr12:49088673(-) A-I      intronic chr12:49102777(-) A-I      intronic chr12:49091490(-) A-I      intronic chr12:49097112(-) A-I      intronic chr12:49095487(-) A-I      intronic chr12:49106108(-) A-I      intronic chr12:49102808(-) A-I      intronic chr12:49091183(-) A-I      intronic chr12:49091550(-) A-I      intronic chr12:49096804(-) A-I      intronic chr12:49107362(-) A-I      intronic chr12:49099328(-) A-I      intronic chr12:49104704(-) A-I      intronic chr12:49096749(-) A-I      intronic chr12:49102859(-) A-I      intronic chr12:49107363(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CCNT1	chr12:49090799(-) A-I intron -    22327324 chr12:49090688(-) A-G intron -    22484847 chr12:49090751(-) A-G intron -    22484847 chr12:49090793(-) A-G intron -    22484847 chr12:49090796(-) A-G intron -    22484847 chr12:49090799(-) A-G intron -    22484847 chr12:49090820(-) A-G intron -    22484847 chr12:49090829(-) A-G intron -    22484847 chr12:49107788(-) A-G intron -    22484847 chr12:49090701(-) A-G intron -    22484847 chr12:49090754(-) A-G intron -    22484847 chr12:49090777(-) A-G intron -    22484847 chr12:49090792(-) A-G intron -    22484847 chr12:49091100(-) A-G intron -    22484847 chr12:49091304(-) A-G intron -    22484847 chr12:49091414(-) A-G intron -    22484847 chr12:49091436(-) A-G intron -    22484847 chr12:49091439(-) A-G intron -    22484847 chr12:49091526(-) A-G intron -    22484847 chr12:49091533(-) A-G intron -    22484847 chr12:49091550(-) A-G intron -    22484847 chr12:49091553(-) A-G intron -    22484847 chr12:49091555(-) A-G intron -    22484847 chr12:49095117(-) G-A intron -    22484847 chr12:49095797(-) T-C intron -    22484847 chr12:49095817(-) A-G intron -    22484847 chr12:49095858(-) A-G intron -    22484847 chr12:49095943(-) A-C intron -    22484847 chr12:49095975(-) A-G intron -    22484847 chr12:49096517(-) A-G intron -    22484847 chr12:49096548(-) A-G intron -    22484847 chr12:49096652(-) A-G intron -    22484847 chr12:49096658(-) A-G intron -    22484847 chr12:49096749(-) A-G intron -    22484847 chr12:49096760(-) A-G intron -    22484847 chr12:49097112(-) A-G intron -    22484847 chr12:49099329(-) A-G intron -    22484847 chr12:49099335(-) A-G intron -    22484847 chr12:49101342(-) A-G intron -    22484847 chr12:49101344(-) A-G intron -    22484847 chr12:49102777(-) A-G intron -    22484847 chr12:49102813(-) A-G intron -    22484847 chr12:49102859(-) A-G intron -    22484847 chr12:49103741(-) A-G intron -    22484847 chr12:49103813(-) A-G intron -    22484847 chr12:49103819(-) A-G intron -    22484847 chr12:49103956(-) A-G intron -    22484847 chr12:49104681(-) A-G intron -    22484847 chr12:49104687(-) A-G intron -    22484847 chr12:49104704(-) A-G intron -    22484847 chr12:49104991(-) A-G intron -    22484847 chr12:49105062(-) A-G intron -    22484847 chr12:49105063(-) A-G intron -    22484847 chr12:49105087(-) A-G intron -    22484847 chr12:49105149(-) A-G intron -    22484847 chr12:49106108(-) A-G intron -    22484847 chr12:49106196(-) A-G intron -    22484847 chr12:49106197(-) A-G intron -    22484847 chr12:49106244(-) A-G intron -    22484847 chr12:49107349(-) A-G intron -    22484847 chr12:49107357(-) A-G intron -    22484847 chr12:49107362(-) A-G intron -    22484847 chr12:49107364(-) A-G intron -    22484847 chr12:49107498(-) A-G intron -    22484847 chr12:49107745(-) A-G intron -    22484847 chr12:49107890(-) A-G intron -    22484847 chr12:49107910(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CCNT1	chr12:49082618-49082619(-) m6A 3'UTR       27773535 chr12:49082634-49082635(-) m6A 3'UTR       27773535 chr12:49082671-49082672(-) m6A 3'UTR       27773535 chr12:49082918-49082919(-) m6A 3'UTR       24981863 chr12:49086391-49086392(-) m6A 3'UTR       24981863//27773535//22608085 chr12:49086463-49086464(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr12:49086568-49086569(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085 chr12:49086686-49086687(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr12:49086710-49086711(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr12:49086746-49086747(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr12:49086774-49086775(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22608085 chr12:49086788-49086789(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22608085 chr12:49086848-49086849(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//22608085 chr12:49086879-49086880(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085 chr12:49087020-49087021(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr12:49087029-49087030(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr12:49087036-49087037(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr12:49087082-49087083(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr12:49087102-49087103(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr12:49087140-49087141(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr12:49087258-49087259(-) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//27371828//22575960//22608085 chr12:49087271-49087272(-) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085 chr12:49087324-49087325(-) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085 chr12:49087345-49087346(-) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085 chr12:49087358-49087359(-) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr12:49087380-49087381(-) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr12:49087462-49087463(-) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr12:49087503-49087504(-) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr12:49087568-49087569(-) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//27773535//27371828//22608085 chr12:49087624-49087625(-) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//27773535//27371828//22608085 chr12:49087659-49087660(-) m6A 3'UTR//CDS       24284625//24981863//26404942//27773535//27371828//22608085 chr12:49087770-49087771(-) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//22608085 chr12:49087945-49087946(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//27371828//22608085 chr12:49087964-49087965(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//27371828//22608085 chr12:49087970-49087971(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//27371828//22608085 chr12:49088118-49088119(-) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//27371828//22608085 chr12:49088152-49088153(-) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//27371828//22608085 chr12:49088164-49088165(-) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//27371828//22608085 chr12:49088176-49088177(-) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//27371828//22608085 chr12:49088197-49088198(-) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//27371828//22608085 chr12:49089576-49089577(-) m6A 3'UTR//CDS//exon       24284625//27773535//27371828//22608085 chr12:49089610-49089611(-) m6A CDS//exon       24284625//27773535//27371828 chr12:49091945-49091946(-) m6A CDS       27773535 chr12:49091956-49091957(-) m6A CDS       27773535 chr12:49093615-49093616(-) m6A CDS       27773535 chr12:49094801-49094802(-) m6A CDS       27773535 chr12:49110318-49110319(-) m6A CDS       24284625//24981863//27773535//22608085 chr12:49110356-49110357(-) m6A CDS       24284625//24981863//27773535//22608085 chr12:49110369-49110370(-) m6A CDS       24284625//24981863//27773535//22608085 chr12:49110407-49110408(-) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr12:49110438-49110439(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-223-5p	Exosome Primary dendritic cells     21505438 Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	CCNT1	Chromatin K562 cells     - Cytosol K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-223-5p
Interactor2: CCNT1

Evidence Support:

Strong-Evidence	Ago2-IP//Luciferase reporter assay//qPCR//Western blot
Weak-Evidence	Microarray
Prediction-Evidence	RNA22//RNAHybrid
Support Database	ViRBase

References:

[1]PMID	22205749	Target region	3'UTR
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	CD4(+) T cells//HeLa cells//Jurkat cells	Interactor2 expression	Downregulation
Description	Cells overexpressing miR-27b showed decreased viral gene expression levels of the HIV-1 reporter virus and a decreased replication of strain NL4.3; a partial rescue of viral transcription could be seen following the transfection of cyclin T1. These results implicate miR-27b as a novel regulator of cyclin T1 protein levels and HIV-1 replication, while miR-29b, miR-223, and miR-150 may regulate cyclin T1 indirectly.

[2]PMID	22936931	Target region	3'UTR
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	CD4(+) T cells//HeLa cells//Jurkat cells	Interactor2 expression	Downregulation
Description	Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions.Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products.