Basic Information
| RNALocate ID: | RLID:11003683 |
| RNA Symbol: | hsa-miR-223-5p |
| Localization: | Exosome |
RNA Information
| RNA Name: | hsa-miR-223-5p |
| RNA ID: | miRBase:MIMAT0004570 |
| RNA Category: | miRNA |
| Species: | Homo sapiens |
Localization Information
| PubMed ID: | 22211110 |
| Tissue/Cell Line: | Breast milk |
| Method: | Next-generation RNA sequencing |
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The expression profile of selected miRNAs in breast milk exosomes. Originally published in Int J Biol Sci. Zhou Q, et al, 2012. Reproduced under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) |
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| Description: | Distribution and characterization of miRNAs in breast milk exosomes. (A) Distribution of pre-miRNAs. Out of 1,424 pre-miRNAs deposited in miRBase 17.0 (blue circle), 87 (6.11%) pre-miRNAs have been designated as immune-related pre-miRNAs based on annotation in the Pathway Central database (SABiosciences, MD, USA). Immune-related pre-miRNAs (59 of 452, 13.05%) are enriched in breast milk exosomes (red circle). χ2 test: Number of immune-related miRNAs and others detected in breast milk exosomes compared with the total entries in miRBase 17.0. (B) Top ten most highly expressed unique miRNAs. Plot of the unique miRNAs (starting from the miRNA with the highest counts, x-axis) versus their cumulative % of the total counts from 602 unique miRNAs detected in breast milk exosomes for each small RNA library. Values are means ± s.d. The dashed horizontal line at 62.3% represents the level of the top ten unique miRNAs and the % of individual miRNAs is marked by the gray line. (C-E) The expression profile of selected miRNAs in breast milk exosomes. (C) 59 immune-related pre-miRNAs; (D) miR-17-92 cluster and paralogous clusters, and (E) ten well-characterized tissue-specific pre-miRNAs. Data are collected from Figure 2. |
Other Subcellular Localization
| RNALocate ID | Localization | Tissue/Cell line | PubMed ID |
| RLID:11003682 | Exosome | Primary dendritic cells | 21505438 |
| RLID:11003684 | Exosome | Plasma | 23663360 |
| RLID:11003685 | Exosome | B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells | 25242326 |
| RLID-D:11000615 | Microvesicle | Fibroblasts|Mesenchymal stem cells | |
| RLID-D:11001492 | Exosome | Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine |
ncRNA Disease Information
| Resource | RNA Symbol | Disease | Link |
| MNDR | hsa-miR-223-5p | Multiple sclerosis chronic progressive | MNDR-E-MI-31271 |
| MNDR | hsa-miR-223-5p | Large cell neuroendocrine cancer | MNDR-E-MI-31272 |
| MNDR | hsa-miR-223-5p | Gastric cancer | MNDR-E-MI-31273 |
| MNDR | hsa-miR-223-5p | Leukemia | MNDR-E-MI-31274 |
| MNDR | hsa-miR-223-5p | Cardiovascular disease | MNDR-E-MI-31275 |
| MNDR | hsa-miR-223-5p | Parkinson disease | MNDR-E-MI-31276 |
| MNDR | hsa-miR-223-5p | Machado-joseph disease | MNDR-E-MI-31277 |
| MNDR | hsa-miR-223-5p | Breast cancer | MNDR-E-MI-31278 |
| MNDR | hsa-miR-223-5p | Pancreatic cancer | MNDR-E-MI-31279 |
| MNDR | hsa-miR-223-5p | Nephroblastoma | MNDR-E-MI-31280 |
| MNDR | hsa-miR-223-5p | Colon cancer | MNDR-E-MI-31281 |
| MNDR | hsa-miR-223-5p | Colon adenocarcinoma | MNDR-E-MI-31282 |
| MNDR | hsa-miR-223-5p | Multiple sclerosis relapsing-remitting | MNDR-E-MI-31283 |
| MNDR | hsa-miR-223-5p | Prostate adenocarcinoma | MNDR-E-MI-31284 |
| MNDR | hsa-miR-223-5p | Glioblastoma | MNDR-E-MI-31285 |
| MNDR | hsa-miR-223-5p | Glioma | MNDR-E-MI-31286 |
| MNDR | hsa-miR-223-5p | Osteosarcoma | MNDR-E-MI-31287 |
| MNDR | hsa-miR-223-5p | Lung squamous cell carcinoma | MNDR-E-MI-31288 |
| MNDR | hsa-miR-223-5p | Non-small cell lung adenocarcinoma | MNDR-E-MI-31289 |
| MNDR | hsa-miR-223-5p | Lung adenocarcinoma | MNDR-E-MI-31290 |
| MNDR | hsa-miR-223-5p | Thyroid carcinoma | MNDR-E-MI-31291 |
| MNDR | hsa-miR-223-5p | Bladder urothelial carcinoma | MNDR-E-MI-31292 |
| MNDR | hsa-miR-223-5p | Pancreatic adenocarcinoma | MNDR-E-MI-31293 |
| MNDR | hsa-miR-223-5p | Kidney renal clear cell carcinoma | MNDR-E-MI-31294 |
| MNDR | hsa-miR-223-5p | Kidney renal papillary cell carcinoma | MNDR-E-MI-31295 |
| MNDR | hsa-miR-223-5p | Renal clear cell carcinoma | MNDR-E-MI-31296 |
| MNDR | hsa-miR-223-5p | Lung small cell carcinoma | MNDR-E-MI-31297 |
| MNDR | hsa-miR-223-5p | Head and neck squamous cell carcinoma | MNDR-E-MI-31298 |
| MNDR | hsa-miR-223-5p | Heart failure | MNDR-E-MI-31299 |
| MNDR | hsa-miR-223-5p | Hepatocellular carcinoma | MNDR-E-MI-31300 |
| MNDR | hsa-miR-223-5p | Rheumatoid arthritis | MNDR-E-MI-31301 |
| MNDR | hsa-miR-223-5p | Hodgkin lymphoma | MNDR-E-MI-31302 |
| MNDR | hsa-miR-223-5p | Skin cutaneous melanoma | MNDR-E-MI-31303 |
| MNDR | hsa-miR-223-5p | Skin melanoma | MNDR-E-MI-31304 |
| MNDR | hsa-miR-223-5p | Colorectal cancer | MNDR-E-MI-31305 |
| MNDR | hsa-miR-223-5p | Wounds and injuries | MNDR-E-MI-31306 |
| MNDR | hsa-miR-223-5p | Intracranial hemorrhage hypertensive | MNDR-E-MI-31307 |
RNA Interaction Information
| Resource | RNA Symbol | Species | Link | RNALocate ID |
| RNAInter | CCNT1 | Homo sapiens | RR00296618 |
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