Basic Information:

  VIRBase ID:  

HHID00096579

  Virus:  

Human immunodeficiency virus 1 (HIV-1)

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-223-3p:  MIMAT0000280          TLR3:  NM_003265     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-223-3p	TLR3
miRBase Accession/Entrez ID	MIMAT0000280	7098
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CD283//IIAE2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-223-3p	rs1182356657 chrX:66018952    T/C rs1244940152 chrX:66018956    C/T rs1437865022 chrX:66018957    C/T rs1482840597 chrX:66018949    A/G rs375191439 chrX:66018939    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TLR3	chr4:187001863(+) A-I      intronic chr4:187003336(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TLR3	chr4:186990367-186990368(+) m6A 5'UTR       24981863 chr4:186997778-186997779(+) m6A CDS       24981863 chr4:187003525-187003526(+) m6A 5'UTR//CDS//exon       24981863 chr4:187003579-187003580(+) m6A 5'UTR//CDS//exon       24981863 chr4:187003649-187003650(+) m6A 5'UTR//CDS//exon       24981863 chr4:187003659-187003660(+) m6A 5'UTR//CDS//exon       24981863 chr4:187003978-187003979(+) m6A CDS//exon       24981863 chr4:187004022-187004023(+) m6A CDS//exon       24284625//24981863 chr4:187004037-187004038(+) m6A CDS//exon       24284625//24981863 chr4:187004177-187004178(+) m6A CDS//exon       24209618//24981863 chr4:187004260-187004261(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187004635-187004636(+) m6A CDS//exon       24981863 chr4:187004686-187004687(+) m6A CDS//exon       24981863 chr4:187004746-187004747(+) m6A CDS//exon       24981863 chr4:187004829-187004830(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187004906-187004907(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187004932-187004933(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187004948-187004949(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187005082-187005083(+) m6A CDS//exon       24284625//24981863 chr4:187005090-187005091(+) m6A CDS//exon       24284625//24981863 chr4:187005095-187005096(+) m6A CDS//exon       24284625//24981863 chr4:187005155-187005156(+) m6A CDS//exon       24284625//24981863 chr4:187005181-187005182(+) m6A CDS//exon       24284625//25456834//24981863 chr4:187005214-187005215(+) m6A CDS//exon       25456834//24981863 chr4:187005236-187005237(+) m6A CDS//exon       25456834//24981863 chr4:187005310-187005311(+) m6A CDS//exon       24981863 chr4:187005888-187005889(+) m6A CDS//exon       24981863 chr4:187005893-187005894(+) m6A CDS//exon       24981863 chr4:187005944-187005945(+) m6A CDS//exon       24981863 chr4:187006013-187006014(+) m6A CDS//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-223-3p	Endoplasmic reticulum membrane Cortical tissue     32451872 Exosome Dendritic cells (in vitro differentiated Langerhans cells)|Healthy plasma|Mast cells (HMC-1 cell line)|PCa patient plasma     25267620 Exosome Macrophages     27396686 Exosome B cell line (Raji)|Primary dendritic cells     21505438 Exosome Breast cancer cell lines (HEK-293T|MDA-MB-231|SKBR3)|Macrophages     21939504 Exosome Ovarian follicular fluid     22116803 Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Plasma     24130905 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Saliva     25376581 Exosome Blood|Breast milk|Mast cells     - Microvesicle Liver resident stem cells|Mesenchymal stem cells     20668554 Microvesicle Plasma     23077538 Microvesicle Follicular fluid     23666971 Microvesicle Fibroblasts|Mesenchymal stem cells     -
	TLR3	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-223-3p	Gemcitabine 60750 Drug interaction    RC00002247 Clopidogrel 60606 Drug interaction    RC00002246 Testosterone 6013 Drug interaction    RC00002242 Cholesterol 5997 Drug interaction    RC00002241 Mitomycin 5746 Drug interaction    RC00002240 RETINOIC ACID, 13-cis- 5538 Drug interaction    RC00002239 Vorinostat 5311 Drug interaction    RC00002252 Genistein 5280961 Drug interaction    RC00002251 Praziquantel 4891 Drug interaction    RC00002238 Tretinoin 444795 Drug interaction    RC00002250 Paclitaxel 36314 Drug interaction    RC00002245 5-Fluorouracil 3385 Drug interaction    RC00002237 Doxorubicin 31703 Drug interaction    RC00002244 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00002236 Chlorzoxazone 2733 Drug interaction    RC00002235 Benzene 241 Drug interaction    RC00002234 Erlotinib 176870 Drug interaction    RC00002249 Methamphetamine 10836 Drug interaction    RC00002243 modified ALLIC BFM 2002 protocol - Drug interaction    RC00002253 Nesiritide - Drug interaction    RC00002254 Trastuzumab - Drug interaction    RC00002255 1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00002256 Interleukin 13 (IL-13) - Drug interaction    RC00002258 Glucocorticoid - Drug interaction    RC00002257

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-223-3p	Docetaxel 148124       29518547

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-223-3p
Interactor2: TLR3

Evidence Support:

Strong-Evidence	qRT-PCR
Support Database	ViRBase

References:

PMID	20636339	Target region	None
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	CD4(+) T cells	Interactor2 expression	None
Description	Further more, TLR-3 activation in macrophages induced the expression of cellular microRNAs(miRNA-28, -125b, -150, -223 and -382), the newly identified intracellular HIV restriction factors. TLR-3 activation inhibits HIV-1 infection of macrophages