Detail Information

Basic Information:


  VIRBase ID:  

HHID00096533

  Virus:  

Human immunodeficiency virus (HIV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-320a-5p:           EGR3:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-320a-5p EGR3
miRBase
Accession/Entrez ID		 MIMAT0037311 1960
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - EGR-3//PILOT

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-320a-5p
rs1178430716 chr8:22245014    C/A
rs1178430716 chr8:22245014    C/T
rs1222383224 chr8:22245020    A/C
rs1302873200 chr8:22245028    C/T
rs751837733 chr8:22245017    G/A
rs751837733 chr8:22245017    G/T
rs759553956 chr8:22245018    G/A
rs762775040 chr8:22245011    G/A
rs762775040 chr8:22245011    G/C
rs766581008 chr8:22245016    G/A
rs767640621 chr8:22245019    A/G
rs773034756 chr8:22245010    A/G
rs773281428 chr8:22245008    G/A
rs773281428 chr8:22245008    G/C
rs371890344 chr8:22245023    G/A
rs371890344 chr8:22245023    G/C
rs375622631 chr8:22245027    G/A
rs566154595 chr8:22245021    G/A
rs566154595 chr8:22245021    G/C
rs764559789 chr8:22245026    G/A

RNA Editing:


Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED EGR3
chr8:22546823(-) A-I exon 3'UTR    22327324

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase EGR3
chr8:22545508-22545509(-) m6A 3'UTR       26404942
chr8:22545541-22545542(-) m6A 3'UTR       26404942
chr8:22545569-22545570(-) m6A 3'UTR       26404942
chr8:22545577-22545578(-) m6A 3'UTR       26404942
chr8:22545603-22545604(-) m6A 3'UTR       26404942
chr8:22545715-22545716(-) m6A 3'UTR       26404942
chr8:22545727-22545728(-) m6A 3'UTR       26404942
chr8:22545738-22545739(-) m6A 3'UTR       26404942
chr8:22545909-22545910(-) m6A 3'UTR       26404942
chr8:22545998-22545999(-) m6A 3'UTR       28052920//26404942
chr8:22546057-22546058(-) m6A 3'UTR       28052920//26404942
chr8:22547371-22547372(-) m6A 3'UTR       26404942
chr8:22547392-22547393(-) m6A 3'UTR       26404942
chr8:22547405-22547406(-) m6A 3'UTR       26404942
chr8:22547576-22547577(-) m6A 3'UTR       28052920//26404942//27371828
chr8:22547621-22547622(-) m6A 3'UTR       28052920//26404942//27371828
chr8:22547659-22547660(-) m6A 3'UTR       28052920//26404942//27371828
chr8:22547670-22547671(-) m6A 3'UTR       28052920//26404942//27371828
chr8:22548347-22548348(-) m6A 3'UTR//CDS//exon       28052920//27371828
chr8:22548442-22548443(-) m6A 3'UTR//CDS//exon       24284625//28052920//27371828
chr8:22548461-22548462(-) m6A 3'UTR//CDS//exon       24284625//28052920//27371828
chr8:22548502-22548503(-) m6A 3'UTR//CDS//exon       24284625//24981863//28052920//27371828
chr8:22548598-22548599(-) m6A 3'UTR//CDS//exon       24284625//28052920//26404942//27371828
chr8:22548850-22548851(-) m6A 3'UTR//CDS//exon       24284625//26404942
chr8:22548905-22548906(-) m6A 3'UTR//CDS//exon       26404942
chr8:22548948-22548949(-) m6A 3'UTR//CDS//exon       26404942
chr8:22548982-22548983(-) m6A 3'UTR//CDS//exon       26404942
chr8:22550586-22550587(-) m6A 5'UTR       28052920//27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-320a-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Human cervical cancer cell line (HeLa)     25760330
Exosome Pooled sera     27278097
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Ovarian follicular fluid     22116803
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Serum     25135963
Exosome Human esophageal cancer cell line (EC9706)     25184951
Exosome Colon cancer cell line (LIM1863)     25330373
Exosome Cerebrospinal fluid     25420022
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Serum     24797360
Mitochondrion HEK-293 cells|HeLa cells     27396686
Mitochondrion HEK-293 cells|HeLa cells     27563705
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
EGR3
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-320a-5p
Interactor2: EGR3

Evidence Support:


Weak-Evidence Small RNA sequencing
Prediction-Evidence miRNet
Support Database ViRBase

References:


PMID 33045840 Target region None
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line PBMC cells Interactor2 expression Downregulation
Description FIG. 2.(B) upregulated miRNAs with their predicted downregulated gene targets.

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