Detail Information

Basic Information:


  VIRBase ID:  

HHID00093604

  Virus:  

Human polyomavirus 1 (BKV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9136

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-10a-5p:           IL6:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-10a-5p IL6
miRBase
Accession/Entrez ID		 MIMAT0000253 3569
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - BSF-2//BSF2//CDF//HGF//HSF//IFN-beta-2//IFNB2//IL-6

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-10a-5p
rs1161287321 chr17:48579915    A/G
rs369632753 chr17:48579914    G/A
rs375865628 chr17:48579904    C/T
rs529115879 chr17:48579905    A/T
rs760091682 chr17:48579917    C/A
rs760091682 chr17:48579917    C/T
rs772649724 chr17:48579909    A/G
rs985848773 chr17:48579913    G/A
rs985848773 chr17:48579913    G/T
rs1157653116 chr17:48579919    ACAGGG/A
rs1333990950 chr17:48579925    T/C
rs1391955925 chr17:48579920    C/T
rs1453440972 chr17:48579922    G/C
rs770328167 chr17:48579924    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR IL6
chr7:22770700(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase IL6
chr7:22766885-22766886(+) m6A 5'UTR//CDS//exon       -
chr7:22766928-22766929(+) m6A exon//intron       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-10a-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Cell lines (MCF10A|MCF-7|MDA-MB-231)     25446899
Exosome Renal cancer cells     21670082
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Urine     25135963
Exosome Cerebrospinal fluid     25420022
Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Hepatoma cells     23771658
Microvesicle Cerebrospinal fluid     24797360
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Colon adenocarcinoma cells     20864815
IL6
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Serum     -
Nucleus HeLa-S3 cells     -
Polysome HeLa cells     26000482

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-10a-5p
[[4-(3-Aminophenyl)-2-pyridyl]methyleneamino]thiourea 9556427 Drug resistant
Berberine iodide 72350 Drug resistant
Resorufin 69462 Drug resistant
Antibiotic 1907-VIII 5477807 Drug resistant
8B-Hydroxy-9B,10B-epoxyverrucarin A 5477536 Drug resistant
2-trans-n-Buten-1-yl-estradiol 5468334 Drug resistant
Methyl-Gag 54598306 Drug resistant
2-Methoxy-5-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol 5386397 Drug resistant
Rhamnazin 5320945 Drug resistant
Plumericin 5281545 Drug resistant
Dichloroplatinum; 2-(4-methoxyphenyl)ethanamine 498558 Drug resistant
Bindschedler's green 458960 Drug resistant
BAS100 Monohydrate 45028404 Drug resistant
Antineoplastic-656904 376224 Drug resistant
Diisopropoxybis(1,4-naphthochinone-2-olato)titanium(IV) 368058 Drug resistant
6,7-Diacetoxyisoflavan 353129 Drug resistant
Cinerubin A hcl 24196924 Drug sensitive
Cytembena 23665583 Drug resistant
Benzamide, N-(5-chloro-2-methoxyphenyl)-2-hydroxy-3-nitro- 186169 Drug resistant
Verrucarin A 9,10-epoxide 181390 Drug sensitive
{4-[5-(4-Fluoro-phenyl)-3-(1-methyl-piperidin-4-yl)-3H-imidazol-4-yl]-pyrimidin-2-yl}-phenyl-amine 17892742 Drug sensitive
(2R)-2-Hydroxy-3-[(6R)-11-hydroxy-2-[4-[(6R)-4-hydroxy-2-[1-hydroxy-3-[(6S)-3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl]butyl]-3-methylidenespiro[4a,7,8,8a-tetrahydro-4H-pyrano[3,2-b]pyran-6,5'-oxolane]-2'-yl]but-3-en-2-yl]-4-methyl-1,7-dioxaspiro[5.5]undec-4-en-8-yl]-2-methylpropanoic acid 146158002 Drug resistant
(1S,3S,5'R,6S,6'S,8R,9Z,14R,15S,16R,17R,18R,19S,20S,21E,25S,27S,29R)-3,14,15,17,19,20-Hexahydroxy-6'-[(2S)-2-hydroxybutyl]-16-[(2S,4R,5S,6R)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-5',6,14,18,20,29-hexamethylspiro[4,24,28-trioxatricyclo[23.3.1.03,8]nonacosa-9,21-diene-27,2'-oxane]-23-one 139589095 Drug resistant
N-[(1S,4R,7S,11R,14S,17R,20S,24R,27S)-2,4,12,15,17,25-Hexamethyl-27-methylsulfanyl-3,6,10,13,16,19,23,26-octaoxo-11,24-di(propan-2-yl)-20-(quinoxaline-2-carbonylamino)-9,22-dioxa-28-thia-2,5,12,15,18,25-hexazabicyclo[12.12.3]nonacosan-7-yl]quinoxaline-2-carboxamide 138402870 Drug resistant
15-Deacetylsergeolide 125729 Drug resistant
aquatris(1,3-diphenylpropane-1,3-dionato)neodymium(iii) - Drug resistant
c4, carbonyl, ethyl prodigiosine - Drug resistant
cis-difluorobis(1-phenylhexane-1,3-dionato)titanium(iv) - Drug resistant
roridin a, 8-hydroxy-9b,10b-epoxy- - Drug resistant
bisarylpurine - Drug resistant
tetra(isobutenyl)antimony bromide - Drug resistant
3,3,4,4,4-pentachloro-1-phenylbutan-1-one - Drug sensitive
6-nitro-1-indazolecarboxy-4'-chloro-2'-anisidide - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-10a-5p
10-Hydroxycamptothecin 97226 Drug interaction    RC00001704
Formaldehyde 712 Drug interaction    RC00001692
Oxaliplatine 6857599 Drug interaction    RC00001712
Cytarabine 6253 Drug interaction    RC00001698
Alocrest 60780 Drug interaction    RC00001703
Gemcitabine 60750 Drug interaction    RC00001702
Temozolomide 5394 Drug interaction    RC00001697
Sunitinib 5329102 Drug interaction    RC00001711
Eloxatine 5310940 Drug interaction    RC00001710
Imatinib 5291 Drug interaction    RC00001696
Sirolimus 5284616 Drug interaction    RC00001709
Tretinoin 444795 Drug interaction    RC00001707
Cyclopamine 442972 Drug interaction    RC00001706
Paclitaxel 36314 Drug interaction    RC00001701
5-Fluorouracil 3385 Drug interaction    RC00001695
Doxorubicin 31703 Drug interaction    RC00001700
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001694
Tamoxifen 2733526 Drug interaction    RC00001708
Anisomycin 253602 Drug interaction    RC00001705
Verapamil 2520 Drug interaction    RC00001693
Arsenic trioxide 14888 Drug interaction    RC00001699
Leucovorin 135403648 Drug interaction    RC00001713
Mistletoe lectin-I - Drug interaction    RC00001715
RAR-alpha antagonist Ro-41-5253 - Drug interaction    RC00001716
Glucocorticoid - Drug interaction    RC00001714
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-10a-5p
Gemcitabine 60750       29615098
Cisplatin 5702198       26676926

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-10a-5p
Interactor2: IL6

Evidence Support:


Strong-Evidence qRT-PCR
Weak-Evidence MiRNA sequencing//RNA-Seq
Prediction-Evidence microRNA.org//PicTar//PITA//TarBase//Targetscan
Support Database ViRBase

References:


PMID 31410940 Target region None
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line Normal human renal proximal tubule epithelial cells Interactor2 expression Upregulation
Description Proteins upregulated by knockdown of miR-10 include MAP3K7, NF-kB, IL-6, IL-8, and MCP-1.

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