Detail Information

Basic Information:


  VIRBase ID:  

HHID00093595

  Virus:  

Respiratory syncytial virus

  Host:  

Homo sapiens

  Confidence Score:  

0.8808

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      MEG3:           CXCL8:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol MEG3 CXCL8
miRBase
Accession/Entrez ID		 55384 3576
Organism Homo sapiens Homo sapiens
Category lncRNA mRNA
Alias FP504//GTL2//LINC00023//NCRNA00023//onco-lncRNA-83//prebp1//PRO0518//PRO2160 GCP-1//GCP1//IL8//LECT//LUCT//LYNAP//MDNCF//MONAP//NAF//NAP-1//NAP1//SCYB8

RNA Editing:


Resource Symbol Editing Position
Lncediting MEG3
    chr14: 101319315
    chr14: 101319442
    chr14: 101312645
    chr14: 101312647
    chr14: 101317814
    chr14: 101318742
    chr14: 101317779
    chr14: 101317798
    chr14: 101316955
    chr14: 101316953
    chr14: 101316952
    chr14: 101316222
    chr14: 101316958
    chr14: 101317570
    chr14: 101317841
    chr14: 101318040
    chr14: 101318393
Resource Symbol Editing Position Change Genetic Region
RADAR MEG3
chr14:101312645(+) A-I      ncRNA
chr14:101312647(+) A-I      ncRNA
chr14:101320975(+) A-I      intronic
chr14:101316952(+) A-I      intronic
chr14:101317570(+) A-I      intronic
chr14:101317779(+) A-I      intronic
chr14:101317798(+) A-I      intronic
chr14:101316953(+) A-I      intronic
chr14:101320992(+) A-I      intronic
chr14:101318393(+) A-I      intronic
chr14:101319315(+) A-I      intronic
chr14:101316955(+) A-I      intronic
chr14:101316958(+) A-I      intronic
chr14:101317814(+) A-I      intronic
chr14:101317841(+) A-I      intronic
chr14:101318040(+) A-I      intronic
chr14:101319442(+) A-I      intronic
chr14:101320973(+) A-I      intronic
chr14:101316222(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED MEG3
chr14:101312645(+) A-I intron -    19478186
chr14:101312647(+) A-I intron -    19478186
chr14:101318040(+) A-I intron -    19478186
chr14:101323109(+) A-I intron -    19478186

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MEG3
chr14:101293768-101293769(+) m6A exon//intron       -
chr14:101293779-101293780(+) m6A exon//intron       -
chr14:101295437-101295438(+) m6A exon       24981863
chr14:101295462-101295463(+) m6A exon       24981863
chr14:101295468-101295469(+) m6A exon       24981863
chr14:101295500-101295501(+) m6A exon       24981863
chr14:101295506-101295507(+) m6A exon       24981863
chr14:101298366-101298367(+) m6A exon//intron       24981863
chr14:101298413-101298414(+) m6A exon//intron       24981863
chr14:101298434-101298435(+) m6A exon//intron       24981863
chr14:101298440-101298441(+) m6A exon//intron       24981863
chr14:101298449-101298450(+) m6A exon//intron       24981863
chr14:101298473-101298474(+) m6A exon//intron       24981863
chr14:101298501-101298502(+) m6A exon//intron       24981863
chr14:101312217-101312218(+) m6A exon//intron       -
chr14:101312286-101312287(+) m6A exon//intron       -
chr14:101312392-101312393(+) m6A exon//intron       -
chr14:101312419-101312420(+) m6A exon//intron       -
chr14:101312425-101312426(+) m6A exon//intron       -
chr14:101312499-101312500(+) m6A exon//intron       -
chr14:101312523-101312524(+) m6A exon//intron       -
chr14:101315936-101315937(+) m6A exon//intron       24981863
chr14:101315969-101315970(+) m6A exon//intron       24981863
chr14:101326624-101326625(+) m6A exon//intron       -
chr14:101326641-101326642(+) m6A exon//intron       -
chr14:101327044-101327045(+) m6A exon//intron       25456834//24981863
chr14:101327068-101327069(+) m6A exon//intron       25456834//24981863
chr14:101327077-101327078(+) m6A exon//intron       25456834//24981863
chr14:101327085-101327086(+) m6A exon       25456834//24981863
chr14:101327092-101327093(+) m6A exon       25456834//24981863
chr14:101327117-101327118(+) m6A exon       25456834//24981863
chr14:101327158-101327159(+) m6A exon       25456834//24981863
chr14:101327171-101327172(+) m6A exon       25456834//24981863
chr14:101327192-101327193(+) m6A exon       25456834//24981863
CXCL8
chr4:74606289-74606290(+) m6A 5'UTR//exon       24981863//26404942
chr4:74606299-74606300(+) m6A 5'UTR//exon       24981863//26404942
chr4:74606324-74606325(+) m6A 5'UTR//exon       24981863//26404942//27773535
chr4:74606341-74606342(+) m6A 5'UTR//exon       24981863//26404942//27773535
chr4:74606354-74606355(+) m6A 5'UTR//exon       24981863//26404942//27773535
chr4:74606373-74606374(+) m6A 5'UTR//exon       24981863//26404942//27773535
chr4:74607286-74607287(+) m6A CDS//exon       27773535
chr4:74607308-74607309(+) m6A CDS//exon       27773535
chr4:74607319-74607320(+) m6A CDS//exon       26404942//27773535
chr4:74607346-74607347(+) m6A CDS//exon       26404942//27773535
chr4:74607367-74607368(+) m6A CDS//exon       26404942//27773535
chr4:74607434-74607435(+) m6A exon//intron       26404942
chr4:74608331-74608332(+) m6A 3'UTR       27773535
chr4:74608370-74608371(+) m6A 3'UTR       27773535
chr4:74608413-74608414(+) m6A 3'UTR       27773535
chr4:74608510-74608511(+) m6A 3'UTR       26404942//27773535
chr4:74608579-74608580(+) m6A 3'UTR       26404942//27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate MEG3
Cytoplasm Hepatoma cells     21625215
Cytoplasm Human lens epithelial cells (SRA01/04)     32841649
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Serum     -
Nucleus Cell line (BT-549)     26205790
Nucleus HeLa cells     31107149
Nucleus Cell lines (GM12878|HeLaS3|HepG2)|Human umbilical vein endothelial cells     22955988
Nucleus Lung fibroblasts     25630241
Nucleus Human lens epithelial cells (SRA01/04)     32841649
CXCL8
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR MEG3
cis-Diaminedichloroplatinum 2767 Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter MEG3
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00000012
Resource Symbol Drug Name PubChem ID
RNAactDrug MEG3
6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide       9956222
6-((2-((4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile       9956119
Benzamide, N-[4-[2-ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]-       9952773
5-(5-(7-(Trifluoromethyl)quinolin-4-ylthio)pentyloxy)-2-(morpholinomethyl)-4H-pyran-4-one dihydrochloride       9938202
Tivozanib       9911830
5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxamide       9903786
5Z-7-Oxozeaenol       9863776
2-(4-(Benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl)-6-methylpyridine       9858940
N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide       9826528
9H-Purine, 6-(ethylthio)-9-beta-D-ribofuranosyl-(8CI)(9CI)       95846
6-Benzylthioinosine       95263
Benzethonium chloride       8478
3,6-Acridinediamine, 2,7,9-trimethyl-, monohydrochloride       72769
N-(3-Methylphenyl)-4-pyridin-4-yl-1,3-thiazol-2-amine       704473
(S)-N-Hydroxy-4-(3-methyl-2-phenylbutanamido)benzamide       6918848
Belinostat       6918638
2-(2-Chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide       6918454
Temsirolimus       6918289
Daporinad       6914657
N-(5-(4-Chloro-3-(N-(2-hydroxyethyl)sulfamoyl)phenyl)-4-methylthiazol-2-yl)acetamide       6852167
Tanespimycin       6505803
Ispinesib mesylate       6450816
Axitinib       6450551
Pelitinib       6445562
4-(N-Hydroxyacetamido)stilbene       6433723
Cytarabine       6253
Primaquine phosphate       6135
3-(2-Phenyl-5-pyridin-4-yl-1H-imidazol-4-yl)phenol;hydrochloride       57399804
5-[2-[4-(Aminomethyl)phenyl]-5-pyridin-4-yl-1H-imidazol-4-yl]-2-chlorophenol;hydrochloride       57399803
Phyllanthastatin 1       5477587
Viridenomycin       54686463
2-(1-Benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetic acid       54685215
Lfm-a13       54676905
Mito-tempol       54613387
Permethyl deriv. of cristatic acid       5458762
Rubremetinium chloride       5351504
N-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide       53340664
Palbociclib       5330286
N-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[(E)-2-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-5-yl)ethenyl]-4-methylbenzamide       53302361
Bosutinib       5328940
Vorinostat       5311
Isotretinoin       5282379
2-Morpholino-6-(thianthren-1-yl)-4H-pyran-4-one       5278396
Bis(2-hydroxy-1-naphthyl) disulfide       521106
6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide       5113032
Tubastatin A       49850262
2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one       4713
2-[(4s)-6-(4-Chlorophenyl)-8-Methoxy-1-Methyl-4h-[1,2,4]triazolo[4,3-A][1,4]benzodiazepin-4-Yl]-N-Ethylacetamide       46943432
3-(4-(4-(2-(3-((Dimethylamino)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-ethyl-1H-pyrazol-3-yl)phenyl)-1,1-dimethylurea       46885626
N-(6,6-Dimethyl-5-(1-methylpiperidine-4-carbonyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-3-methylbutanamide       46191454
N-(2,2,2-Trifluoroethyl)-N-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}benzenesulfonamide       447912
Tretinoin       444795
Dabrafenib       44462760
4-[1-(4-Aminomethyl-phenyl)-1H-imidazo[4,5-c]pyridin-2-yl]-furazan-3-ylamine       44397453
Refametinib       44182295
Foretinib       42642645
Benzofurazan, 4-(4-methyl-1-piperazinyl)-7-nitro-, 3-oxide       42640
Vemurafenib       42611257
1,6-Bis[4-(4-aminophenoxy)phenyl]diamantane       397904
1-(2-(Hydroxymethyl)-1,3-dioxolan-4-yl)cytosine       381525
2-Chloro-3-(3-(N-morpholino)propylamino)-naphthazarine       379081
3,5-Dimethyl-1-nitroso-2,6-diphenyl-4-piperidinone       362605
3,4-Dihydroxynaphthalene-2-carboxylic acid       356138
5-Fluorouracil       3385
Cetalkonium chloride       31202
[5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol       25262965
2-(4-Methyl-1,4-diazepan-1-yl)-N-((5-methylpyrazin-2-yl)methyl)-5-oxo-5H-benzo[4,5]thiazolo[3,2-a][1,8]naphthyridine-6-carboxamide       25257557
Cabozantinib       25102847
Navitoclax       24978538
Tert-Butyl (4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenyl)carbamate       24951314
Ponatinib       24826799
Vismodegib       24776445
4-(6,6-Dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide       24772860
Arylidene-4-chloro       24202977
(2-Methoxy-9,10-dihydrophenanthren-3-yl)methyl-dimethyl-(phenylsulfanylmethyl)azanium;bromide       24200489
Arenaemycin E       24199350
Thalphenine chloride       24197663
Vincaleukoblastine       241903
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide       24180719
Olaparib       23725625
Tricinolone acetophenonide       235856
Aristolochic acid       2236
6-Chloro-2-methoxy-9-[(5-piperidinopentyl)amino]acridine       219600
7-(alpha-Anilino-P-nitrobenzyl)-8-quinolinol       219565
Nutlin-3       216345
Lenalidomide       216326
Kinetin riboside       20345
4-Methyl-3-(1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)-N-(3-(trifluoromethyl)phenyl)benzamide       16747388
Gsk-690693       16725726
Fedratinib       16722836
1-(Tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea       1401
N-[5-[5-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-pyridin-4-ylfuran-3-yl]-2,3-dihydroinden-1-ylidene]hydroxylamine;hydrochloride       136207967
4-[(5z)-5-(1-Nitroso-2,3-Dihydro-5h-Inden-5-Ylidene)-2-(Piperidin-4-Yl)-3,5-Dihydro-4h-Imidazol-4-Ylidene]-1,4-Dihydropyridine       136026031
(Z)-3-((3-((Dimethylamino)methyl)phenylamino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-carboxamide       135659062
Talazoparib       135565082
N,N-Dimethyl-2-[4-[4-(1-nitroso-2,3-dihydroinden-5-ylidene)-5-(1H-pyridin-4-ylidene)-1H-imidazol-2-yl]phenoxy]ethanamine       135564599
(E)-5-(2-(4-(2-(Dimethylamino)ethoxy)phenyl)-5-(pyridin-4-yl)-1H-imidazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime       135421339
Osi-027       135398516
Dovitinib       135398510
Methotrexate       126941
Lestaurtinib       126565
Dactolisib       11977753
Clofarabine       119182
BAY 61-3606 dihydrochloride       11784504
N-[3-[[5-Bromo-4-[[2-(1H-imidazol-5-YL)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide       11754511
Trametinib       11707110
4-[2-(2-Chloro-4-fluoroanilino)-5-methyl-4-pyrimidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide       11634725
Benzamide, 4-((1R)-1-aminoethyl)-N-1H-pyrrolo(2,3-b)pyridin-4-yl-, hydrochloride (1:1)       11507964
5-(2-Phenylpyrazolo[1,5-A]pyridin-3-YL)-1H-pyrazolo[3,4-C]pyridazin-3-amine       11493598
Linifanib       11485656
Nvp-aew541       11476171
N-(6-Fluoro-1H-indazol-5-yl)-6-methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-pyridine-5-carboxamide       11373846
8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one       11327430
Amuvatinib       11282283
(S)-5-(3-Fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide       11152667
7-Ethyl-10-hydroxycamptothecin       104842
VX-702       10341154
Afatinib       10184653
Selumetinib       10127622
N-(3-{[5-Iodo-4-({3-[(Thiophen-2-Ylcarbonyl)amino]propyl}amino)pyrimidin-2-Yl]amino}phenyl)pyrrolidine-1-Carboxamide       10077147
Masitinib       10074640
25-Dihydrosaframycin A       100180
1,4-dimethoxy-7-azaisoindole[2,1-a]quinoxalin-6(5h)-one       -
1-bromo-2-bromomethyl-o-carborane       -
;4-fluoro-N-(3-(4-(6-(4-hydroxyphenyl)imidazo[2,1-b]thia...       -
5,6-ethylenediquino[3,2-b       -
8,8'-(3,3'-dimethoxybenzyl)-8-hydroxy-butyrolacton       -
b 80568       -
bis-.mu.-propionatodiaquatetrabromorhenium(ii)       -
Cisplatin       -
formamide, n-[4-(3,3-dimethyl-1-triazenyl)phenyl]-       -
Genentech Cpd 10       -
g-tpp       -
JW-7-24-1       -
KIN001-236       -
KIN001-244       -
KIN001-260       -
KIN001-266       -
KIN001-270       -
MPS-1-IN-1       -
NPK76-II-72-1       -
Nutlin-3a (-)       -
propanedinitrile, [(3,5-dibromo-2-ethoxyphenyl)methylene]-       -
purino[7,8-a]quinazoline-5,9,11-trione, 6,8,10-trimethyl-       -
QL-X-138       -
QL-XI-92       -
riboprine(usan)       -
SB52334       -
THZ-2-102-1       -
TL-1-85       -
TL-2-105       -
triacetyl 13,14,15-isocrambescidin 800 hydrochloride       -
VNLG/124       -
WZ3105       -
XMD14-99       -
XMD15-27       -

Interaction Network (The top 100 interactions):


Interactor1: MEG3
Interactor2: CXCL8

Evidence Support:


Strong-Evidence RT-qPCR//Western blot
Support Database ViRBase

References:


PMID 29257348 Target region None
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line BEAS-2B cells Interactor2 expression Upregulation
Description Additionally, RSV-induced upregulation of TNF-alpha and IL-8 may also be reduced by ectopic expression of lncRNA MEG3 (Fig. 3D and E), indicating the protective role of lncRNA MEG3 in RSV infection.

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