Detail Information

Basic Information:


  VIRBase ID:  

HHID00092751

  Virus:  

Influenza A virus (A/Brisbane/10/2007(H3N2))

  Host:  

Homo sapiens

  Confidence Score:  

0.6743

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-371a-5p:           IL6:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-371a-5p IL6
miRBase
Accession/Entrez ID		 MIMAT0004687 3569
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - BSF-2//BSF2//CDF//HGF//HSF//IFN-beta-2//IFNB2//IL-6

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-371a-5p
rs1004685112 chr19:53787689    G/C
rs1318684148 chr19:53787691    G/C
rs772543475 chr19:53787692    G/C
rs1034874198 chr19:53787693    G/C
rs1049004182 chr19:53787684    A/C
rs1049004182 chr19:53787684    A/G
rs1185000692 chr19:53787682    T/C
rs1202234248 chr19:53787687    C/T
rs1428290628 chr19:53787686    A/AC
rs1480794990 chr19:53787686    A/C
rs770734168 chr19:53787687    CTG/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR IL6
chr7:22770700(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase IL6
chr7:22766885-22766886(+) m6A 5'UTR//CDS//exon       -
chr7:22766928-22766929(+) m6A exon//intron       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-371a-5p
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Exosome Human mast cell line (HMC-1)     24009880
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841
IL6
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Serum     -
Nucleus HeLa-S3 cells     -
Polysome HeLa cells     26000482

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-371a-5p
10-Hydroxycamptothecin 97226 Drug interaction    RC00007074
Gemcitabine 60750 Drug interaction    RC00007073
Progesterone 5994 Drug interaction    RC00007072
Calcitriol 5280453 Drug interaction    RC00007075
5-Fluorouracil 3385 Drug interaction    RC00007071
Testosterone + 1,25-Dihydroxyvitamin D3 - Drug interaction    RC00007076
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-371a-5p
CID 14440697 14440697       21293479

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-371a-5p
Interactor2: IL6

Evidence Support:


Weak-Evidence MiRNA microarray//RNA-Seq
Prediction-Evidence microRNA.org//PITA//Targetscan
Support Database ViRBase

References:


PMID 30605755 Target region None
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line A549 cells Interactor2 expression Upregulation
Description B. Relationships between miRNAs and inversely correlated mRNAs involved in the host defense to virus. Green and red represent downregulated and upregulated genes, while triangles and circles represent miRNAs and target gene mRNAs, respectively.

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