Basic Information:

  VIRBase ID:  

HHID00092692

  Virus:  

Influenza A virus (H1N1)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-361-5p:  MIMAT0000703          MAPK13:  NR_072996     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-361-5p	MAPK13
miRBase Accession/Entrez ID	MIMAT0000703	5603
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	MAPK 13//MAPK-13//p38delta//PRKM13//SAPK4

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-361-5p	rs1201941835 chrX:85903694    T/C rs1341659793 chrX:85903684    C/A rs1430235395 chrX:85903683    A/AC

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MAPK13	chr6:36102409(+) A-I      intronic chr6:36102309(+) A-I      intronic chr6:36102713(+) A-I      intronic chr6:36102641(+) A-I      intronic chr6:36104892(+) A-I      intronic chr6:36102698(+) A-I      intronic chr6:36102270(+) A-I      intronic chr6:36102670(+) A-I      intronic chr6:36102614(+) A-I      intronic chr6:36102249(+) A-I      intronic chr6:36102427(+) A-I      intronic chr6:36102684(+) A-I      intronic chr6:36102372(+) A-I      intronic chr6:36102712(+) A-I      intronic chr6:36102451(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MAPK13	chr6:36102198(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MAPK13	chr6:36098407-36098408(+) m6A CDS//exon       - chr6:36098428-36098429(+) m6A CDS//exon       - chr6:36098677-36098678(+) m6A exon//intron       - chr6:36098697-36098698(+) m6A exon//intron       - chr6:36098713-36098714(+) m6A exon//intron       - chr6:36106508-36106509(+) m6A CDS       - chr6:36106751-36106752(+) m6A 3'UTR//CDS       24284625//24981863 chr6:36106800-36106801(+) m6A 3'UTR//CDS       24284625//25456834//24981863 chr6:36106809-36106810(+) m6A 3'UTR//CDS       24284625//25456834 chr6:36107094-36107095(+) m6A 3'UTR//CDS       25456834//24981863//22608085 chr6:36107118-36107119(+) m6A 3'UTR//CDS       24284625//25456834//24981863//22608085 chr6:36107152-36107153(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr6:36107180-36107181(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr6:36107193-36107194(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr6:36107214-36107215(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr6:36107252-36107253(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr6:36107325-36107326(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr6:36107355-36107356(+) m6A 3'UTR       24284625//25456834//22608085 chr6:36107497-36107498(+) m6A 3'UTR       25456834 chr6:36107512-36107513(+) m6A 3'UTR       25456834 chr6:36107520-36107521(+) m6A 3'UTR       25456834

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-361-5p	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Neural progenitor cells     21363885 Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Serum     18589210 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Renal cancer cells     21670082 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Serum     25349172 Exosome Blood|Kidney tissue     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Seminal plasma     23539611 Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Nasopharyngeal carcinoma cells     20498841
	MAPK13	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-361-5p	7-Epi-10-deacetylbaccatin III 9872117 Drug sensitive Pharmakon1600-01503602 60148415 Drug sensitive Ayanin 5280682 Drug resistant Rogiolol 402519 Drug sensitive 2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant Jasplakinolide epoxide C 372550 Drug sensitive Antineoplastic-642316 369949 Drug sensitive Gold;(2S,3R,4S,5R,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxane-2-thiolate;triethylphosphanium 138402869 Drug sensitive Dibutyltin dichloride 12688 Drug sensitive Capri Blue 102162 Drug sensitive 6-aryl alkyl fluoro quinolone derivative - Drug resistant antineoplastic-d655481 - Drug resistant 2-[(3,4-dicloro)anilino]-3-phenyl-5,7-diamino quinoxaline - Drug sensitive 4-[3-(3,4-dihydro-1H-isoquinolin-2-yl)prop-1-en-2-yl]-N-pyrazin-2-ylbenzamide - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-361-5p	Formaldehyde 712 Drug interaction    RC00004017 Gemcitabine 60750 Drug interaction    RC00004022 Eloxatine 5310940 Drug interaction    RC00004027 Diethylstilbestrol 448537 Drug interaction    RC00004025 Paclitaxel 36314 Drug interaction    RC00004021 5-Fluorouracil 3385 Drug interaction    RC00004019 Doxorubicin 31703 Drug interaction    RC00004020 Tamoxifen 2733526 Drug interaction    RC00004026 Verapamil 2520 Drug interaction    RC00004018 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00004028 Docetaxel 148124 Drug interaction    RC00004024 Methotrexate 126941 Drug interaction    RC00004023 Glucocorticoid - Drug interaction    RC00004031 platinum-based doublet chemotherapy - Drug interaction    RC00004029 1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00004030

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-361-5p	N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-361-5p	Topotecan       60700 Palbociclib       5330286

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-361-5p
Interactor2: MAPK13

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	miRanda//RNA22//Targetscan
Support Database	ViRBase

References:

PMID	23731466	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	PBMCs	Interactor2 expression	Downregulation
Description	P38 MAPKs(MAPK11, MAPK13, and MAPK14) were found to be regulated by miR-769-5p, miR-146b-5p, let-7g, miR-30b, miR-31, miR-361-3p, and miR-362-3p, which were all down expressed in H1N1 critically ill patients.