Detail Information

Basic Information:


  VIRBase ID:  

HHID00092502

  Virus:  

Influenza A virus (A/swine/Guangxi/3861/2011(H1N1))

  Host:  

Homo sapiens

  Confidence Score:  

0.6743

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1915-3p:           IL6:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1915-3p IL6
miRBase
Accession/Entrez ID		 MIMAT0007892 3569
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - BSF-2//BSF2//CDF//HGF//HSF//IFN-beta-2//IFNB2//IL-6

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-1915-3p
rs1319660164 chr10:21496576    C/T
rs1335396985 chr10:21496581    C/G
rs1359100620 chr10:21496582    G/A
rs1416262346 chr10:21496578    C/A
rs540277336 chr10:21496579    G/A
rs540277336 chr10:21496579    G/C
rs983068182 chr10:21496591    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR IL6
chr7:22770700(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase IL6
chr7:22766885-22766886(+) m6A 5'UTR//CDS//exon       -
chr7:22766928-22766929(+) m6A exon//intron       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-1915-3p
Exosome Pooled sera     27278097
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
IL6
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Serum     -
Nucleus HeLa-S3 cells     -
Polysome HeLa cells     26000482

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1915-3p
Interactor2: IL6

Evidence Support:


Weak-Evidence MiRNA microarray//RNA-Seq
Prediction-Evidence microRNA.org//PITA//Targetscan
Support Database ViRBase

References:


PMID 30605755 Target region None
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line A549 cells Interactor2 expression Upregulation
Description B. Relationships between miRNAs and inversely correlated mRNAs involved in the host defense to virus. Green and red represent downregulated and upregulated genes, while triangles and circles represent miRNAs and target gene mRNAs, respectively.

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