Detail Information

Basic Information:


  VIRBase ID:  

HHID00092011

  Virus:  

Influenza A virus (A/California/07/2009(H1N1))

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-149-3p:           PRKCG:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-149-3p PRKCG
miRBase
Accession/Entrez ID		 MIMAT0004609 5582
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - PKC-gamma//PKCC//PKCG//PKCgamma//PKCI(3)//SCA14

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-149-3p
rs1010751133 chr2:240456073    G/A
rs1010751133 chr2:240456073    G/C
rs1010751133 chr2:240456073    G/T
rs1165267714 chr2:240456066    G/T
rs1248860515 chr2:240456074    T/C
rs1283632093 chr2:240456072    T/C
rs1284461395 chr2:240456075    G/T
rs1299093493 chr2:240456069    G/A
rs1320221915 chr2:240456076    C/G
rs1358442678 chr2:240456067    G/T
rs1399133005 chr2:240456068    G/T
rs1445917433 chr2:240456071    C/A
rs1445917433 chr2:240456071    C/T
rs963649591 chr2:240456070    G/A
rs963649591 chr2:240456070    G/T
rs1405842421 chr2:240456062    G/A
rs1412989618 chr2:240456061    G/C
rs1412989618 chr2:240456061    G/T
rs747327479 chr2:240456058    G/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PRKCG
chr19:54398692(+) A-I      intronic
chr19:54389784(+) A-I      intronic
chr19:54399266(+) A-I      intronic
chr19:54399803(+) A-I      intronic
chr19:54389696(+) A-I      intronic
chr19:54398622(+) A-I      intronic
chr19:54392233(+) A-I      intronic
chr19:54389198(+) A-I      intronic
chr19:54397880(+) A-I      intronic
chr19:54389929(+) A-I      intronic
chr19:54398591(+) A-I      intronic
chr19:54390596(+) A-I      intronic
chr19:54389632(+) A-I      intronic
chr19:54399936(+) A-I      intronic
chr19:54389445(+) A-I      intronic
chr19:54405477(+) A-I      intronic
chr19:54389620(+) A-I      intronic
chr19:54390599(+) A-I      intronic
chr19:54397740(+) A-I      intronic
chr19:54397949(+) A-I      intronic
chr19:54398631(+) A-I      intronic
chr19:54389783(+) A-I      intronic
chr19:54399836(+) A-I      intronic
chr19:54390604(+) A-I      intronic
chr19:54389726(+) A-I      intronic
chr19:54397831(+) A-I      intronic
chr19:54397843(+) A-I      intronic
chr19:54389545(+) A-I      intronic
chr19:54399193(+) A-I      intronic
chr19:54398654(+) A-I      intronic
chr19:54389710(+) A-I      intronic
chr19:54397897(+) A-I      intronic
chr19:54389570(+) A-I      intronic
chr19:54398638(+) A-I      intronic
chr19:54388758(+) A-I      intronic
chr19:54399042(+) A-I      intronic
chr19:54398707(+) A-I      intronic
chr19:54388586(+) A-I      intronic
chr19:54389199(+) A-I      intronic
chr19:54399839(+) A-I      intronic
chr19:54390937(+) A-I      intronic
chr19:54389549(+) A-I      intronic
chr19:54397814(+) A-I      intronic
chr19:54389751(+) A-I      intronic
chr19:54389439(+) A-I      intronic
chr19:54398662(+) A-I      intronic
chr19:54390562(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PRKCG
chr19:54382523-54382524(+) m6A 5'UTR       24981863
chr19:54382555-54382556(+) m6A 5'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-149-3p
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome B cell line (Raji)|Jurkat-derived T cell line (J77cl20)     21505438
Exosome Plasma     23663360
Exosome K562 cells     24460325
Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293)     22984580
PRKCG
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-149-3p
Ethyl phenylpropiolate 91516 Drug resistant
Clothixamide maleate 76972759 Drug resistant
Phosphotrienin 6913994 Drug resistant
Sulbentine 67686 Drug resistant
Tacacoside A2 6712615 Drug resistant
1,3,8-Trihydroxy-6-methoxyanthracene-9,10-dione 636723 Drug resistant
Primaquine phosphate 6135 Drug resistant
6-[2-[(2-Methylsulfonylethylamino)methyl]-1,3-thiazol-4-yl]-N-[4-[[3-(trifluoromethyl)phenyl]methoxy]phenyl]quinazolin-4-amine;hydrochloride 57395317 Drug sensitive
Thiopyrimidine-CH3 5473238 Drug resistant
Tetrocarcin A, sodium salt 54724658 Drug resistant
p-Chloranilinum[bis(p-chloraniline)dioxalatoruthenate(III)] 54608061 Drug resistant
Cyclosporin A 5284373 Drug resistant
9-beta-D-Xylofuranosyladenine 447916 Drug sensitive
Oxyacanthine 442333 Drug resistant
10-Hydroxy-5-methoxy-1-(2-methyloxiran-2-yl)-1,2-dihydrofuro[2,3-c]xanthen-6-one 429905 Drug resistant
S-(Diisopropylarsino)-3-mercapto-1,2-propanediol 406478 Drug resistant
Aminopyrimidine-CH3 406278 Drug resistant
Fagaronine chloride 40304 Drug sensitive
11-Hydroxyusambarine Chlorhydrate 401426 Drug resistant
5'-Formyl-2,5-bis(2'-selenyl)-N-methylpyrrol 394652 Drug sensitive
3-(4-Fluorophenyl)-3-(4-hydroxy-2-methylphenyl)-2-benzofuran-1(3H)-one 387973 Drug sensitive
3,8-Dimethyl-1,2-naphthoquinone 373912 Drug resistant
4-(1-Benzofuran-2-yl)-7-methoxychromen-2-one 364364 Drug sensitive
4-Nitro-6-(trifluoromethyl)-2,1,3-benzoselenadiazole 362897 Drug resistant
Imidazole, 1-(4-chlorophenyl)-4-(4-nitrophenyl)- 355940 Drug sensitive
Acronycine, 2-nitro 342903 Drug resistant
Clomifene citrate 3033832 Drug resistant
N-[(4R)-4-[(3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Tris(3-aminopropoxy)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentyl]octan-1-amine 24205348 Drug resistant
4,5-Bis(4-methoxyphenyl)-1,5-dihydroimidazol-2-one 231112 Drug resistant
4-[5-(2-Amino-pyrimidin-4-yl)-4-(4-fluoro-phenyl)-imidazol-1-yl]-cyclohexanol 22464120 Drug sensitive
4-Chloro-5-phenoxy-3H-1,2-dithiole-3-thione 16766044 Drug resistant
Cysteine, S-[(4-aminocarbonyl-1H-imidazol-5-yl)azo]- 135493928 Drug resistant
DTIC-Dome 135398738 Drug resistant
(2R,4R,6S,7S,12S)-6,7,16-Trihydroxy-18-methoxy-12-methyl-3,13-dioxatricyclo[13.4.0.02,4]nonadeca-1(15),9,16,18-tetraene-8,14-dione 131676399 Drug resistant
Acetylenedicarboxamide 10971 Drug resistant
(S)-Morpholin-3-ylmethyl (4-((1-(3-fluorobenzyl)-1H-indazol-5-yl)amino)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)carbamate 10437018 Drug sensitive
Selumetinib 10127622 Drug resistant
(1R,6S,11aS,13S,14aR)-1,13-dihydroxy-6-vinyl-1,6,7,8,9,11a,12,13,14,14a-decahydro-4H-cyclopenta[f]oxacyclotridecin-4-one - Drug resistant
(E)-2-(2-(benzo[d][1,3]dioxol-5-yl)vinyl)-5-(3-methyl-1H-pyrazol-5-yl)-1,3,4-oxadiazole - Drug resistant
(E)-8-(4-chlorobenzylidene)-4-(4-chlorophenyl)-3,4,5,6,7,8-hexahydroquinazolin-2-amine - Drug resistant
1,1'-biphenyl, 4,4'bis(thiomethyl)- - Drug resistant
2,3,4-tri-o-acetyl-1-s-dimethylarsino-1-thio- a -d-xylose - Drug resistant
4(1h)-quinazolinone, 2-(2-chlorophenyl)-2,3-dihydro- - Drug resistant
4-[3-(3,4-dihydro-1H-isoquinolin-2-yl)prop-1-en-2-yl]-N-pyrazin-2-ylbenzamide - Drug resistant
5,6-dimethyl-9-oxo-9h-xanthene-4-acetic acid, sodium salt - Drug resistant
b676297k277 3',4'-deoxypsorospermin 3',4'-chlorohydrin - Drug resistant
benzo[1,2-b:4,5-b']dithiophene-4,8-diol, dipropionate - Drug resistant
benzo[b]naphtho[2,3-d]furan-6,11-dione, 4-chloro-3-hydroxy - Drug resistant
dimethylarsinothious acid, 2,4-pyrimidinediyl ester - Drug resistant
pyrimidine, 2,4,5-trichloro-6-ethyl- - Drug resistant
pyrimidine, 2,4,5-trichloro-6-isopropyl- - Drug resistant
7-ethyl-9-methoxy-5-ethoxycamptothecin - Drug resistant
b705009k098 - Drug resistant
crambescidin 800 trihydrochloride - Drug resistant
somatostatin analog in diacetic form mw=1067.2 - Drug resistant
1,3-diphenyl-4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1H-pyrazole - Drug sensitive
6-phenyl-6h-indeno[1,2-c]isoquinoline-5,11-dione - Drug sensitive
indole-2,3-dione, 5-methyl-, 3-[(o-nitrophenyl)hydrazone] - Drug sensitive
antineoplastic-d655481 - Drug sensitive
geldanamycin dimethylglycinate - Drug sensitive
organosulfur compound - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-149-3p
5-Fluorouracil 3385 Drug interaction    RC00006967
Celecoxib 2662 Drug interaction    RC00006966
Trastuzumab - Drug interaction    RC00006968
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-149-3p
Platinum 23939       25872328

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-149-3p
Interactor2: PRKCG

Evidence Support:


Weak-Evidence MiRNA microarray
Prediction-Evidence microRNA.org//PITA//Targetscan
Support Database ViRBase

References:


PMID 29059211 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HUVECs Interactor2 expression None
Description The differential miRNAs and their target genes in the above pathways were concluded in Table S1 and Table S2.

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