Detail Information

Basic Information:


  VIRBase ID:  

HHID00092002

  Virus:  

Influenza A virus (A/California/07/2009(H1N1))

  Host:  

Homo sapiens

  Confidence Score:  

0.9124

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-582-5p:           TRIM27:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-582-5p TRIM27
miRBase
Accession/Entrez ID		 MIMAT0003247 5987
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - RFP//RNF76

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-582-5p
rs1190339760 chr5:59703674    G/A
rs1291143355 chr5:59703672    T/A
rs1455812678 chr5:59703667    G/GT
rs753758364 chr5:59703675    T/C
rs779684016 chr5:59703670    A/C
rs779684016 chr5:59703670    A/G
rs1245677877 chr5:59703684    T/A
rs373502275 chr5:59703686    T/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TRIM27
chr6:28884133(-) A-I      intronic
chr6:28884095(-) A-I      intronic
chr6:28884087(-) A-I      intronic
chr6:28884085(-) A-I      intronic
chr6:28883987(-) A-I      intronic
chr6:28883964(-) A-I      intronic
chr6:28883959(-) A-I      intronic
chr6:28883934(-) A-I      intronic
chr6:28883907(-) A-I      intronic
chr6:28883897(-) A-I      intronic
chr6:28883876(-) A-I      intronic
chr6:28883867(-) A-I      intronic
chr6:28883865(-) A-I      intronic
chr6:28883862(-) A-I      intronic
chr6:28883858(-) A-I      intronic
chr6:28883854(-) A-I      intronic
chr6:28883832(-) A-I      intronic
chr6:28883831(-) A-I      intronic
chr6:28883822(-) A-I      intronic
chr6:28883818(-) A-I      intronic
chr6:28883796(-) A-I      intronic
chr6:28883790(-) A-I      intronic
chr6:28883779(-) A-I      intronic
chr6:28883726(-) A-I      intronic
chr6:28883328(-) A-I      intronic
chr6:28883277(-) A-I      intronic
chr6:28883264(-) A-I      intronic
chr6:28883262(-) A-I      intronic
chr6:28883256(-) A-I      intronic
chr6:28883254(-) A-I      intronic
chr6:28880011(-) A-I      intronic
chr6:28880789(-) A-I      intronic
chr6:28880790(-) A-I      intronic
chr6:28883333(-) A-I      intronic
chr6:28883336(-) A-I      intronic
chr6:28883246(-) A-I      intronic
chr6:28882185(-) A-I      intronic
chr6:28882179(-) A-I      intronic
chr6:28882158(-) A-I      intronic
chr6:28882072(-) A-I      intronic
chr6:28882050(-) A-I      intronic
chr6:28881985(-) A-I      intronic
chr6:28881973(-) A-I      intronic
chr6:28881829(-) A-I      intronic
chr6:28880996(-) A-I      intronic
chr6:28880870(-) A-I      intronic
chr6:28880145(-) A-I      intronic
chr6:28880119(-) A-I      intronic
chr6:28880114(-) A-I      intronic
chr6:28880106(-) A-I      intronic
chr6:28880105(-) A-I      intronic
chr6:28881810(-) A-I      intronic
chr6:28881859(-) A-I      intronic
chr6:28881875(-) A-I      intronic
chr6:28881943(-) A-I      intronic
chr6:28882201(-) A-I      intronic
chr6:28884674(-) A-I      intronic
chr6:28884676(-) A-I      intronic
chr6:28884698(-) A-I      intronic
chr6:28884702(-) A-I      intronic
chr6:28885773(-) A-I      intronic
chr6:28885779(-) A-I      intronic
chr6:28885780(-) A-I      intronic
chr6:28885781(-) A-I      intronic
chr6:28886918(-) A-I      intronic
chr6:28886944(-) A-I      intronic
chr6:28886957(-) A-I      intronic
chr6:28886959(-) A-I      intronic
chr6:28886963(-) A-I      intronic
chr6:28886964(-) A-I      intronic
chr6:28880950(-) A-I      intronic
chr6:28887068(-) A-I      intronic
chr6:28887060(-) A-I      intronic
chr6:28887007(-) A-I      intronic
chr6:28886983(-) A-I      intronic
chr6:28886922(-) A-I      intronic
chr6:28886552(-) A-I      intronic
chr6:28886531(-) A-I      intronic
chr6:28886473(-) A-I      intronic
chr6:28886450(-) A-I      intronic
chr6:28885875(-) A-I      intronic
chr6:28885870(-) A-I      intronic
chr6:28885845(-) A-I      intronic
chr6:28885772(-) A-I      intronic
chr6:28884819(-) A-I      intronic
chr6:28885651(-) A-I      intronic
chr6:28885278(-) A-I      intronic
chr6:28884892(-) A-I      intronic
chr6:28884824(-) A-I      intronic
chr6:28883951(-) A-I      intronic
chr6:28878244(-) A-I      intronic
chr6:28878308(-) A-I      intronic
chr6:28878374(-) A-I      intronic
chr6:28878388(-) A-I      intronic
chr6:28884811(-) A-I      intronic
chr6:28884761(-) A-I      intronic
chr6:28884328(-) A-I      intronic
chr6:28884246(-) A-I      intronic
chr6:28884242(-) A-I      intronic
chr6:28884164(-) A-I      intronic
chr6:28877062(-) A-I      intronic
chr6:28880066(-) A-I      intronic
chr6:28886958(-) A-I      intronic
chr6:28877066(-) A-I      intronic
chr6:28885317(-) A-I      intronic
chr6:28884668(-) A-I      intronic
chr6:28877786(-) A-I      intronic
chr6:28885680(-) A-I      intronic
chr6:28885309(-) A-I      intronic
chr6:28883334(-) A-I      intronic
chr6:28879983(-) A-I      intronic
chr6:28884073(-) A-I      intronic
chr6:28885354(-) A-I      intronic
chr6:28883727(-) A-I      intronic
chr6:28881898(-) A-I      intronic
chr6:28885233(-) A-I      intronic
chr6:28884217(-) A-I      intronic
chr6:28886991(-) A-I      intronic
chr6:28882184(-) A-I      intronic
chr6:28882139(-) A-I      intronic
chr6:28885742(-) A-I      intronic
chr6:28885728(-) A-I      intronic
chr6:28880025(-) A-I      intronic
chr6:28883130(-) A-I      intronic
chr6:28886483(-) A-I      intronic
chr6:28877828(-) A-I      intronic
chr6:28883373(-) A-I      intronic
chr6:28881828(-) A-I      intronic
chr6:28886606(-) A-I      intronic
chr6:28886395(-) A-I      intronic
chr6:28880054(-) A-I      intronic
chr6:28887006(-) A-I      intronic
chr6:28876990(-) A-I      intronic
chr6:28880065(-) A-I      intronic
chr6:28877839(-) A-I      intronic
chr6:28886961(-) A-I      intronic
chr6:28886398(-) A-I      intronic
chr6:28886981(-) A-I      intronic
chr6:28884266(-) A-I      intronic
chr6:28883286(-) A-I      intronic
chr6:28884904(-) A-I      intronic
chr6:28886396(-) A-I      intronic
chr6:28877858(-) A-I      intronic
chr6:28877061(-) A-I      intronic
chr6:28881995(-) A-I      intronic
chr6:28883274(-) A-I      intronic
chr6:28882076(-) A-I      intronic
chr6:28880083(-) A-I      intronic
chr6:28884173(-) A-I      intronic
chr6:28884684(-) A-I      intronic
chr6:28877882(-) A-I      intronic
chr6:28886900(-) A-I      intronic
chr6:28881926(-) A-I      intronic
chr6:28880256(-) A-I      intronic
chr6:28877867(-) A-I      intronic
chr6:28887054(-) A-I      intronic
chr6:28883372(-) A-I      intronic
chr6:28880829(-) A-I      intronic
chr6:28880776(-) A-I      intronic
chr6:28886967(-) A-I      intronic
chr6:28885308(-) A-I      intronic
chr6:28884797(-) A-I      intronic
chr6:28883366(-) A-I      intronic
chr6:28877819(-) A-I      intronic
chr6:28886876(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TRIM27
chr6:28872732(-) A-I intron -    15258596
chr6:28872768(-) A-I intron -    15258596
chr6:28872805(-) A-I intron -    15258596
chr6:28872830(-) A-I intron -    15258596
chr6:28872841(-) A-I intron -    15258596
chr6:28872864(-) A-I intron -    15258596
chr6:28873794(-) A-I intron -    15258596
chr6:28877061(-) A-I intron -    15258596
chr6:28877062(-) A-I intron -    15258596
chr6:28877063(-) A-I intron -    15258596
chr6:28877066(-) A-I intron -    15258596
chr6:28873918(-) A-G intron -    21725310

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TRIM27
chr6:28870899-28870900(-) m6A 3'UTR//exon       24284625
chr6:28871029-28871030(-) m6A 3'UTR//exon       24284625//24981863
chr6:28871070-28871071(-) m6A 3'UTR//exon       24284625
chr6:28872066-28872067(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr6:28872097-28872098(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr6:28872219-28872220(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr6:28872238-28872239(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr6:28872278-28872279(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr6:28872351-28872352(-) m6A CDS//exon       24284625//24209618//22575960
chr6:28873054-28873055(-) m6A exon//intron       27773535
chr6:28873080-28873081(-) m6A exon//intron       27773535
chr6:28873141-28873142(-) m6A exon//intron       27773535
chr6:28873546-28873547(-) m6A exon//intron       27773535
chr6:28873551-28873552(-) m6A exon//intron       27773535
chr6:28873573-28873574(-) m6A exon//intron       27773535
chr6:28873608-28873609(-) m6A exon//intron       27773535
chr6:28879484-28879485(-) m6A CDS//exon       27773535
chr6:28882560-28882561(-) m6A exon//intron       27773535
chr6:28882566-28882567(-) m6A exon//intron       27773535
chr6:28882577-28882578(-) m6A exon//intron       27773535
chr6:28882598-28882599(-) m6A exon//intron       27773535
chr6:28882621-28882622(-) m6A exon//intron       27773535
chr6:28882668-28882669(-) m6A exon//intron       27773535
chr6:28882869-28882870(-) m6A exon//intron       27773535
chr6:28882991-28882992(-) m6A exon//intron       27773535
chr6:28883037-28883038(-) m6A exon//intron       27773535
chr6:28883053-28883054(-) m6A exon//intron       27773535
chr6:28887912-28887913(-) m6A CDS//exon       27773535//22575960
chr6:28889674-28889675(-) m6A CDS//exon       24981863//27773535//22575960
chr6:28889689-28889690(-) m6A CDS//exon       24981863//27773535//22575960
chr6:28889750-28889751(-) m6A CDS//exon       24981863//27773535//27371828//27773536//22575960
chr6:28891080-28891081(-) m6A CDS//exon       24284625//27371828//27773536
chr6:28891234-28891235(-) m6A CDS//exon       24284625//24981863//27371828//27773536//22575960
chr6:28891264-28891265(-) m6A CDS//exon       24284625//24981863//27371828//27773536//22575960
chr6:28891369-28891370(-) m6A CDS//exon       24284625//24981863//27371828//27773536//22575960
chr6:28891491-28891492(-) m6A 5'UTR//exon       27773536//22575960
chr6:28891498-28891499(-) m6A 5'UTR//exon       27773536//22575960
chr6:28891693-28891694(-) m6A 5'UTR       24284625//24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-582-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Plasma     23663360
Exosome Serum     25349172
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
TRIM27
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)|K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-582-5p
Iodine Green 9956454 Drug sensitive
Indolo[2,1-b]quinazoline-6,12-dione 73549 Drug sensitive
Secalonic acid D 73431 Drug sensitive
1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive
6-(4-Ethylphenyl)-2-benzenesulfonamidepyridazine-3(2H)-one 54612980 Drug sensitive
Herveline O 5459269 Drug sensitive
Cuspidatin C 5459164 Drug sensitive
Staurosporine, 98% 49831000 Drug resistant
Methyl (13S,15S,16R,18S)-13-[(10S,11R,12R,19R)-11-acetyloxy-12-ethyl-10-hydroxy-5-methoxy-10-methoxycarbonyl-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraen-4-yl]-18-ethyl-1-oxido-17-oxa-11-aza-1-azoniapentacyclo[13.4.1.04,12.05,10.016,18]icosa-4(12),5,7,9-tetraene-13-carboxylate 462173 Drug sensitive
o6-Benzylguanine 4578 Drug resistant
Triciribine phosphate 43860 Drug resistant
Aminopyrimidine-CH3 406278 Drug sensitive
Aminopyrimidine-F 406276 Drug sensitive
Acetic acid,4,7,10-tetraazacyclododecane-1,7-diyl]bis 387352 Drug sensitive
Hookerianamide J 25016666 Drug sensitive
Antimycin A3 245869 Drug sensitive
Kinetin riboside 20345 Drug resistant
4-[[(1-Benzylpyrazolo[3,4-d]pyrimidin-4-yl)hydrazinylidene]methyl]-2-methoxyphenol 136091540 Drug resistant
Astrazon Orange R 135747272 Drug sensitive
1-[(2-cyclohexymethoxy)methyl]-5-ethyl-6-iodouracil - Drug resistant
tunicamycin - Drug resistant
(z) 4-acetoxy-(3,4',5)-trimethoxystilbene - Drug sensitive
2k2S,S? - Drug sensitive
4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive
phosphonium, triphenylpropenyl-, bromide, (e)- (8ci) - Drug sensitive
(Z)-6-chloro-3-((2-(4-methoxyphenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive
dichlorobisoxinatotitanium(iv) - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-582-5p
Formaldehyde 712 Drug interaction    RC00006017
Alocrest 60780 Drug interaction    RC00006022
Vincristine 5978 Drug interaction    RC00006020
Sunitinib 5329102 Drug interaction    RC00006023
Doxorubicin 31703 Drug interaction    RC00006021
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00006019
Verapamil 2520 Drug interaction    RC00006018
Navitoclax 24978538 Drug interaction    RC00006024
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-582-5p
Cisplatin 5702198       21575166
Sirolimus 5284616       30666128
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-582-5p
N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide       9826528
l-685,458       5479543
Selumetinib       10127622

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-582-5p
Interactor2: TRIM27

Evidence Support:


Strong-Evidence qRT-PCR
Weak-Evidence Deep sequencing//Microarray
Prediction-Evidence microRNA.org//PITA//Targetscan
Support Database ViRBase

References:


PMID 31207403 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Relationships between 4 miRNAs and 5 inversely correlated target genes selected in qRT-PCR.

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