Basic Information
| RNALocate ID: | RLID:11003264 |
| RNA Symbol: | hsa-miR-582-5p |
| Localization: | Exosome |
RNA Information
| RNA Name: | hsa-miR-582-5p |
| RNA ID: | miRBase:MIMAT0003247 |
| RNA Category: | miRNA |
| Species: | Homo sapiens |
Localization Information
| PubMed ID: | 25349172 |
| Tissue/Cell Line: | Serum |
| Method: | Next-generation RNA sequencing |
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Originally published in Mol Psychiatry. Cheng L, et al, 2015. Reproduced under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) |
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| Description: | Deep sequencing of the exosomal RNA extracted from serum samples was performed and sequences were mapped to miRBase Exosomal miRNA biomarkers for Alzheimer's disease. Approximately half of the reads obtained (43%) from small RNA sequencing corresponded with miRNA sequences (Supplementary Table 1). Overall, the sample cohort mapped to 1419 known human miRNA sequences (Supplementary Table 2). Following normalisation of reads and performing ANOVA analyses, 17 miRNA were found to be significantly deregulated (Figure 1); 14 miRNA were found to be upregulated (hsa-miR-361-5p, hsa-miR-30e-5p, hsa-miR-93-5p, hsa-miR-15a-5p, hsa-miR-143-3p, hsa-miR-335-5p, hsa-miR-106b-5p, hsa-miR-101-3p, hsa-miR-424-5p, hsa-miR-106a-5p, hsa-miR-18b-5p, hsa-miR-3065-5p, hsa-miR-20a-5p and hsa-miR-582-5p) and three miRNA were found to be downregulated (hsa-miR-1306-5p, hsa-miR-342-3p and 15b-3p; Table 2). Data are collected from Table 2. |
Other Subcellular Localization
| RNALocate ID | Localization | Tissue/Cell line | PubMed ID |
| RLID:01002441 | Cytoplasm | Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa) | 24918059 |
| RLID:01002442 | Mitochondrion | Skeletal muscle myoblasts | 21637849 |
| RLID:01002443 | Nucleus | Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa) | 24918059 |
| RLID:11003263 | Exosome | Plasma | 23663360 |
| RLID-D:11000518 | Microvesicle | Colon cancer cell line (LIM1863)|Mesenchymal stem cells | |
| RLID-D:11001344 | Exosome | Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine |
ncRNA Disease Information
| Resource | RNA Symbol | Disease | Link |
| MNDR | hsa-miR-582-5p | Multiple sclerosis chronic progressive | MNDR-E-MI-61779 |
| MNDR | hsa-miR-582-5p | Medulloblastoma | MNDR-E-MI-61780 |
| MNDR | hsa-miR-582-5p | Uterine corpus endometrial carcinoma | MNDR-E-MI-61781 |
| MNDR | hsa-miR-582-5p | Lymphoma | MNDR-E-MI-61782 |
| MNDR | hsa-miR-582-5p | Estrogen-receptor negative breast cancer | MNDR-E-MI-61783 |
| MNDR | hsa-miR-582-5p | Progesterone-receptor negative breast cancer | MNDR-E-MI-61784 |
| MNDR | hsa-miR-582-5p | Her2-receptor positive breast cancer | MNDR-E-MI-61785 |
| MNDR | hsa-miR-582-5p | Prostate cancer | MNDR-E-MI-61786 |
| MNDR | hsa-miR-582-5p | Gastric cancer | MNDR-E-MI-61787 |
| MNDR | hsa-miR-582-5p | Alzheimer disease | MNDR-E-MI-61788 |
| MNDR | hsa-miR-582-5p | Intracranial aneurysm | MNDR-E-MI-61789 |
| MNDR | hsa-miR-582-5p | Bladder cancer | MNDR-E-MI-61790 |
| MNDR | hsa-miR-582-5p | Esophageal carcinoma | MNDR-E-MI-61791 |
| MNDR | hsa-miR-582-5p | Facioscapulohumeral muscular dystrophy | MNDR-E-MI-61792 |
| MNDR | hsa-miR-582-5p | Leukemia | MNDR-E-MI-61793 |
| MNDR | hsa-miR-582-5p | Cardiovascular disease | MNDR-E-MI-61794 |
| MNDR | hsa-miR-582-5p | Uterine fibroid | MNDR-E-MI-61795 |
| MNDR | hsa-miR-582-5p | Lung cancer | MNDR-E-MI-61796 |
| MNDR | hsa-miR-582-5p | Parkinson disease | MNDR-E-MI-61797 |
| MNDR | hsa-miR-582-5p | Breast cancer | MNDR-E-MI-61798 |
| MNDR | hsa-miR-582-5p | Pituitary neoplasms | MNDR-E-MI-61799 |
| MNDR | hsa-miR-582-5p | Malignant mesothelioma | MNDR-E-MI-61800 |
| MNDR | hsa-miR-582-5p | Pancreatic cancer | MNDR-E-MI-61801 |
| MNDR | hsa-miR-582-5p | Melanoma | MNDR-E-MI-61802 |
| MNDR | hsa-miR-582-5p | Rectum adenocarcinoma | MNDR-E-MI-61803 |
| MNDR | hsa-miR-582-5p | Nephroblastoma | MNDR-E-MI-61804 |
| MNDR | hsa-miR-582-5p | Colon cancer | MNDR-E-MI-61805 |
| MNDR | hsa-miR-582-5p | Colon adenocarcinoma | MNDR-E-MI-61806 |
| MNDR | hsa-miR-582-5p | Multiple sclerosis relapsing-remitting | MNDR-E-MI-61807 |
| MNDR | hsa-miR-582-5p | Prostate adenocarcinoma | MNDR-E-MI-61808 |
| MNDR | hsa-miR-582-5p | Glioblastoma | MNDR-E-MI-61809 |
| MNDR | hsa-miR-582-5p | Glioma | MNDR-E-MI-61810 |
| MNDR | hsa-miR-582-5p | Amyotrophic lateral sclerosis | MNDR-E-MI-61811 |
| MNDR | hsa-miR-582-5p | Osteosarcoma | MNDR-E-MI-61812 |
| MNDR | hsa-miR-582-5p | Gastric adenocarcinoma | MNDR-E-MI-61813 |
| MNDR | hsa-miR-582-5p | Pituitary adenoma | MNDR-E-MI-61814 |
| MNDR | hsa-miR-582-5p | Lung squamous cell carcinoma | MNDR-E-MI-61815 |
| MNDR | hsa-miR-582-5p | Lung adenocarcinoma | MNDR-E-MI-61816 |
| MNDR | hsa-miR-582-5p | Bladder urothelial carcinoma | MNDR-E-MI-61817 |
| MNDR | hsa-miR-582-5p | Carcinoma renal cell | MNDR-E-MI-61818 |
| MNDR | hsa-miR-582-5p | Cholangiocarcinoma | MNDR-E-MI-61819 |
| MNDR | hsa-miR-582-5p | Hepatocellular carcinoma | MNDR-E-MI-61820 |
| MNDR | hsa-miR-582-5p | B-cell lymphoma | MNDR-E-MI-61821 |
| MNDR | hsa-miR-582-5p | Retinoblastoma | MNDR-E-MI-61822 |
| MNDR | hsa-miR-582-5p | Hodgkin lymphoma | MNDR-E-MI-61823 |
| MNDR | hsa-miR-582-5p | Colorectal cancer | MNDR-E-MI-61824 |
| MNDR | hsa-miR-582-5p | Epstein-barr virus infections | MNDR-E-MI-61825 |
| MNDR | hsa-miR-582-5p | Solid-pseudopapillary neoplasm of pancreas | MNDR-E-MI-61826 |
RNA Interaction Information
| Resource | RNA Symbol | Species | Link | RNALocate ID |
| RNAInter | CASP3 | Homo sapiens | RR00278989 |
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