Basic Information:

  VIRBase ID:  

HHID00076280

  Virus:  

Murid betaherpesvirus 1

  Host:  

Mus musculus

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      mmu-miR-199a-3p:  MIMAT0000230          Ldha:  NR_102727     

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Interactor Information:

	Interactor1	Interactor2
Symbol	mmu-miR-199a-3p	Ldha
miRBase Accession/Entrez ID	MIMAT0000230	16828
Organism	Mus musculus	Mus musculus
Category	miRNA	mRNA
Alias	-	l7//l7R2//LDH//Ldh-//Ldh1//Ldhm

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	mmu-miR-199a-3p	Exosome Conditioned medium of E13 SMG     28041903 Exosome B6 BMDCs     22031862
	Ldha	Cytosolic polysome Murine plasmacytoma cells (J558)     12923260 ER-bound polysome Murine plasmacytoma cells (J558)     12923260 Exosome Mast cells     17486113

Interaction Network (The top 100 interactions):

Interactor1: mmu-miR-199a-3p
Interactor2: Ldha

Evidence Support:

Weak-Evidence	MiRNA microarray
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	20643939	Target region	None
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	NIH3T3 cells	Interactor2 expression	Downregulation
Description	All of the regulated genes in Fig. 5B are down-regulated by miR-199a-3p mimic and up-regulated by miR-199a-3p inhibitor compared with the negative transfection control, with the exception of ITGA6, which is only up-regulated by the inhibitor (Dataset S3).