Basic Information:

  VIRBase ID:  

HHID00076208

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9933

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-608:  MIMAT0003276          IL6:  NM_001318095     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-608	IL6
miRBase Accession/Entrez ID	MIMAT0003276	3569
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	BSF-2//BSF2//CDF//HGF//HSF//IFN-beta-2//IFNB2//IL-6

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-608	rs1353373743 chr10:100974999    CA/C rs368610511 chr10:100975023    G/A rs4919510 chr10:100975021    C/G rs558234881 chr10:100975014    G/T rs757887469 chr10:100975010    T/C rs770502722 chr10:100975022    C/T rs1313026429 chr10:100975002    G/C rs1397346443 chr10:100975003    G/C rs749799472 chr10:100975006    G/A rs958002673 chr10:100975007    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	IL6	chr7:22770700(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	IL6	chr7:22766885-22766886(+) m6A 5'UTR//CDS//exon       - chr7:22766928-22766929(+) m6A exon//intron       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-608	Exosome Primary ovarian tumor cells|Serum     18589210 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	IL6	Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Serum     - Nucleus HeLa-S3 cells     - Polysome HeLa cells     26000482

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-608	Diethylstilbestrol 448537 Drug interaction    RC00006118 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00006117

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-608	Pha-665752       10461815

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-608
Interactor2: IL6

Evidence Support:

Strong-Evidence	ELISA//IFS//Pull down assay//qPCR//Western blot
Support Database	ViRBase

References:

PMID	21984125	Target region	ORF
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	BCBL-1 cells//HEK293 cells//HeLa cells//JSC-1 cells//RKO cells	Interactor2 expression	Downregulation
Description	To verify the specificity of each miRNA to its target, we generated a chimeric hIL6 by exchanging the corresponding region of hIL6 with the target region of miR-1293 in vIL6 (Figure 3E-F) and demonstrated that the miR-1293 target region of vIL6 could convert miR-1293-resistant hIL6 into miR-1293-sensitive hIL6 (Figure 3G), concluding that vIL6 and hIL6 are separately regulated by miR-1293 and miR-608 through their binding to specific seed matches in the corresponding ORF.