Detail Information

Basic Information:


  VIRBase ID:  

HHID00071582

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1976:           DPP9:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1976 DPP9
miRBase
Accession/Entrez ID		 MIMAT0009451 91039
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - DP9//DPLP9//DPP IX//DPRP-2//DPRP2

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-1976
rs1173366847 chr1:26554586    C/T
rs1208235584 chr1:26554592    G/A
rs985342579 chr1:26554590    C/T
rs1478358767 chr1:26554578    C/T
rs765589931 chr1:26554577    C/G
rs972150493 chr1:26554576    T/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR DPP9
chr19:4681741(-) A-I      intronic
chr19:4681754(-) A-I      intronic
chr19:4681773(-) A-I      intronic
chr19:4706706(-) A-I      intronic
chr19:4706693(-) A-I      intronic
chr19:4681757(-) A-I      intronic
chr19:4681532(-) A-I      intronic
chr19:4681508(-) A-I      intronic
chr19:4681507(-) A-I      intronic
chr19:4681742(-) A-I      intronic
chr19:4680163(-) A-I      intronic
chr19:4680166(-) A-I      intronic
chr19:4706771(-) A-I      intronic
chr19:4706645(-) A-I      intronic
chr19:4706611(-) A-I      intronic
chr19:4681746(-) A-I      intronic
chr19:4680907(-) A-I      intronic
chr19:4705328(-) A-I      intronic
chr19:4701474(-) A-I      intronic
chr19:4701473(-) A-I      intronic
chr19:4697028(-) A-I      intronic
chr19:4697016(-) A-I      intronic
chr19:4696989(-) A-I      intronic
chr19:4680173(-) A-I      intronic
chr19:4696987(-) A-I      intronic
chr19:4696983(-) A-I      intronic
chr19:4696675(-) A-I      intronic
chr19:4696633(-) A-I      intronic
chr19:4696623(-) A-I      intronic
chr19:4696086(-) A-I      intronic
chr19:4696081(-) A-I      intronic
chr19:4696080(-) A-I      intronic
chr19:4696077(-) A-I      intronic
chr19:4680806(-) A-I      intronic
chr19:4696050(-) A-I      intronic
chr19:4696037(-) A-I      intronic
chr19:4696009(-) A-I      intronic
chr19:4694939(-) A-I      intronic
chr19:4691985(-) A-I      intronic
chr19:4691792(-) A-I      intronic
chr19:4680857(-) A-I      intronic
chr19:4691435(-) A-I      intronic
chr19:4691387(-) A-I      intronic
chr19:4696605(-) A-I      intronic
chr19:4681449(-) A-I      intronic
chr19:4691358(-) A-I      intronic
chr19:4681439(-) A-I      intronic
chr19:4680786(-) A-I      intronic
chr19:4715234(-) A-I      intronic
chr19:4715117(-) A-I      intronic
chr19:4714683(-) A-I      intronic
chr19:4714650(-) A-I      intronic
chr19:4714605(-) A-I      intronic
chr19:4681388(-) A-I      intronic
chr19:4714603(-) A-I      intronic
chr19:4712556(-) A-I      intronic
chr19:4711746(-) A-I      intronic
chr19:4709157(-) A-I      intronic
chr19:4709125(-) A-I      intronic
chr19:4708990(-) A-I      intronic
chr19:4706781(-) A-I      intronic
chr19:4681733(-) A-I      intronic
chr19:4681692(-) A-I      intronic
chr19:4681688(-) A-I      intronic
chr19:4681547(-) A-I      intronic
chr19:4706306(-) A-I      intronic
chr19:4695967(-) A-I      intronic
chr19:4681537(-) A-I      intronic
chr19:4716393(-) A-I      intronic
chr19:4691376(-) A-I      intronic
chr19:4712395(-) A-I      intronic
chr19:4712388(-) A-I      intronic
chr19:4695068(-) A-I      intronic
chr19:4707775(-) A-I      intronic
chr19:4705374(-) A-I      intronic
chr19:4695047(-) A-I      intronic
chr19:4718182(-) A-I      intronic
chr19:4692051(-) A-I      intronic
chr19:4706583(-) A-I      intronic
chr19:4709022(-) A-I      intronic
chr19:4704972(-) A-I      intronic
chr19:4705397(-) A-I      intronic
chr19:4691366(-) A-I      intronic
chr19:4692046(-) A-I      intronic
chr19:4715196(-) A-I      intronic
chr19:4716460(-) A-I      intronic
chr19:4680869(-) A-I      intronic
chr19:4712549(-) A-I      intronic
chr19:4695980(-) A-I      intronic
chr19:4705364(-) A-I      intronic
chr19:4696678(-) A-I      intronic
chr19:4680955(-) A-I      intronic
chr19:4696184(-) A-I      intronic
chr19:4708944(-) A-I      intronic
chr19:4698639(-) A-I      intronic
chr19:4706249(-) A-I      intronic
chr19:4709150(-) A-I      intronic
chr19:4705401(-) A-I      intronic
chr19:4706245(-) A-I      intronic
chr19:4706752(-) A-I      intronic
chr19:4711540(-) A-I      intronic
chr19:4705314(-) A-I      intronic
chr19:4712310(-) A-I      intronic
chr19:4692052(-) A-I      intronic
chr19:4715259(-) A-I      intronic
chr19:4709041(-) A-I      intronic
chr19:4692032(-) A-I      intronic
chr19:4696387(-) A-I      intronic
chr19:4706610(-) A-I      intronic
chr19:4709131(-) A-I      intronic
chr19:4704947(-) A-I      intronic
chr19:4680893(-) A-I      intronic
chr19:4712368(-) A-I      intronic
chr19:4715169(-) A-I      intronic
chr19:4709113(-) A-I      intronic
chr19:4692037(-) A-I      intronic
chr19:4705357(-) A-I      intronic
chr19:4706716(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED DPP9
chr19:4709113(-) A-I intron -    21960545
chr19:4675366(-) G-A exon 3'UTR    21725310

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase DPP9
chr19:4675242-4675243(-) m6A 3'UTR       27773535
chr19:4675267-4675268(-) m6A 3'UTR       24981863//27773535
chr19:4675347-4675348(-) m6A 3'UTR       24981863//27773535
chr19:4675568-4675569(-) m6A 3'UTR       24284625
chr19:4675616-4675617(-) m6A 3'UTR       24284625
chr19:4675750-4675751(-) m6A 3'UTR       24284625//24981863
chr19:4675778-4675779(-) m6A 3'UTR//exon       24284625//24981863
chr19:4675809-4675810(-) m6A 3'UTR//exon       24284625//24981863
chr19:4675879-4675880(-) m6A 3'UTR//exon       24981863
chr19:4676262-4676263(-) m6A 3'UTR//exon       -
chr19:4676503-4676504(-) m6A 3'UTR//exon       24981863//27371828
chr19:4676517-4676518(-) m6A 3'UTR//exon       24981863//27371828
chr19:4676650-4676651(-) m6A CDS//exon//intron       27773535
chr19:4679861-4679862(-) m6A 3'UTR//CDS//exon       27773535
chr19:4679895-4679896(-) m6A 3'UTR//CDS//exon       27773535
chr19:4682767-4682768(-) m6A 3'UTR//CDS//exon//intron       27773535
chr19:4685587-4685588(-) m6A exon//intron       -
chr19:4688312-4688313(-) m6A exon//intron       27773535
chr19:4688336-4688337(-) m6A exon//intron       -
chr19:4688608-4688609(-) m6A exon//intron       -
chr19:4688620-4688621(-) m6A exon//intron       -
chr19:4694555-4694556(-) m6A 3'UTR//exon//intron       24284625
chr19:4694756-4694757(-) m6A 3'UTR//CDS//exon       27773535
chr19:4694838-4694839(-) m6A exon//intron       27773535
chr19:4703933-4703934(-) m6A CDS//exon       24284625
chr19:4704010-4704011(-) m6A CDS//exon       24284625//27773535
chr19:4704035-4704036(-) m6A CDS//exon       24284625//27773535
chr19:4704051-4704052(-) m6A CDS//exon       24284625//27773535
chr19:4714302-4714303(-) m6A 3'UTR//CDS//exon//intron       24284625//27773536
chr19:4715628-4715629(-) m6A 5'UTR//intron       -
chr19:4719907-4719908(-) Y 5'UTR//CDS//exon//intron       26075521
chr19:4722521-4722522(-) m6A 5'UTR//exon//intron       24981863//27371828
chr19:4723727-4723728(-) m6A 5'UTR//exon//intron       24981863
chr19:4724670-4724671(-) m5C 5'UTR       23604283
chr19:4724671-4724672(-) m5C 5'UTR       23604283

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-1976
Cytoplasm Cell line (HeLa)     21695135
Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
Mitochondrion Skeletal muscle cells     27563705
DPP9
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -
Ribosome-free cytosol Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-1976
Gemcitabine 60750 Drug interaction    RC00007973
5-Fluorouracil 3385 Drug interaction    RC00007972
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-1976
Panobinostat       6918837
Paclitaxel       36314

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1976
Interactor2: DPP9

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region CDS
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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