Basic Information:

  VIRBase ID:  

HHID00071579

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1976:  MIMAT0009451          RAB9A:  NM_001195328     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1976	RAB9A
miRBase Accession/Entrez ID	MIMAT0009451	9367
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	RAB9

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1976	rs1173366847 chr1:26554586    C/T rs1208235584 chr1:26554592    G/A rs985342579 chr1:26554590    C/T rs1478358767 chr1:26554578    C/T rs765589931 chr1:26554577    C/G rs972150493 chr1:26554576    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RAB9A	chrX:13718154(+) A-I      intronic chrX:13718185(+) A-I      intronic chrX:13718204(+) A-I      intronic chrX:13718193(+) A-I      intronic chrX:13718197(+) A-I      intronic chrX:13714325(+) A-I      intronic chrX:13714444(+) A-I      intronic chrX:13724550(+) A-I      intronic chrX:13726413(+) A-I      intronic chrX:13726304(+) A-I      intronic chrX:13724727(+) A-I      intronic chrX:13724604(+) A-I      intronic chrX:13709691(+) A-I      intronic chrX:13709614(+) A-I      intronic chrX:13709579(+) A-I      intronic chrX:13709734(+) A-I      intronic chrX:13709699(+) A-I      intronic chrX:13714265(+) A-I      intronic chrX:13709623(+) A-I      intronic chrX:13726296(+) A-I      intronic chrX:13726377(+) A-I      intronic chrX:13709700(+) A-I      intronic chrX:13709658(+) A-I      intronic chrX:13709572(+) A-I      intronic chrX:13709659(+) A-I      intronic chrX:13709711(+) A-I      intronic chrX:13709626(+) A-I      intronic chrX:13709569(+) A-I      intronic chrX:13709627(+) A-I      intronic chrX:13709636(+) A-I      intronic chrX:13709632(+) A-I      intronic chrX:13709731(+) A-I      intronic chrX:13709621(+) A-I      intronic chrX:13719020(+) A-I      intronic chrX:13726387(+) A-I      intronic chrX:13726277(+) A-I      intronic chrX:13726241(+) A-I      intronic chrX:13724591(+) A-I      intronic chrX:13719003(+) A-I      intronic chrX:13726177(+) A-I      intronic chrX:13726255(+) A-I      intronic chrX:13726363(+) A-I      intronic chrX:13718253(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	RAB9A	chrX:13709569(+) A-I intron -    22028664 chrX:13709572(+) A-I intron -    22028664 chrX:13709579(+) A-I intron -    22028664 chrX:13709614(+) A-I intron -    22028664 chrX:13709619(+) A-I intron -    22028664 chrX:13709621(+) A-I intron -    22028664 chrX:13709623(+) A-I intron -    22028664 chrX:13709626(+) A-I intron -    22028664 chrX:13709627(+) A-I intron -    22028664 chrX:13709632(+) A-I intron -    22028664 chrX:13709636(+) A-I intron -    22028664 chrX:13709658(+) A-I intron -    22028664 chrX:13709659(+) A-I intron -    22028664 chrX:13709691(+) A-I intron -    22028664 chrX:13709699(+) A-I intron -    22028664 chrX:13709700(+) A-I intron -    22028664 chrX:13709711(+) A-I intron -    22028664 chrX:13709731(+) A-I intron -    22028664 chrX:13709734(+) A-I intron -    22028664 chrX:13726241(+) A-G intron -    22484847 chrX:13726296(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RAB9A	chrX:13721973-13721974(+) m6A 5'UTR//intron       24284625 chrX:13726938-13726939(+) m6A CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chrX:13727023-13727024(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chrX:13727049-13727050(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chrX:13727084-13727085(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chrX:13727154-13727155(+) m6A CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chrX:13727295-13727296(+) m6A CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chrX:13727321-13727322(+) m6A CDS//exon       24284625//24981863//27773535//22575960//22608085 chrX:13727417-13727418(+) m6A CDS//exon       24284625//24981863//26404942//27773535//22608085 chrX:13727583-13727584(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chrX:13727620-13727621(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chrX:13727751-13727752(+) m6A 3'UTR       24981863//27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1976	Cytoplasm Cell line (HeLa)     21695135 Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     - Mitochondrion Skeletal muscle cells     27563705
	RAB9A	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-1976	Gemcitabine 60750 Drug interaction    RC00007973 5-Fluorouracil 3385 Drug interaction    RC00007972

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-1976	Panobinostat       6918837 Paclitaxel       36314

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1976
Interactor2: RAB9A

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.