Basic Information:

  VIRBase ID:  

HHID00071578

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1976:  MIMAT0009451          SP100:  NM_001080391     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1976	SP100
miRBase Accession/Entrez ID	MIMAT0009451	6672
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	lysp100b

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1976	rs1173366847 chr1:26554586    C/T rs1208235584 chr1:26554592    G/A rs985342579 chr1:26554590    C/T rs1478358767 chr1:26554578    C/T rs765589931 chr1:26554577    C/G rs972150493 chr1:26554576    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SP100	chr2:231389471(+) A-I      intronic chr2:231389492(+) A-I      intronic chr2:231389494(+) A-I      intronic chr2:231389495(+) A-I      intronic chr2:231389502(+) A-I      intronic chr2:231389512(+) A-I      intronic chr2:231388556(+) A-I      intronic chr2:231383247(+) A-I      intronic chr2:231388503(+) A-I      intronic chr2:231387219(+) A-I      intronic chr2:231388545(+) A-I      intronic chr2:231389516(+) A-I      intronic chr2:231389517(+) A-I      intronic chr2:231389538(+) A-I      intronic chr2:231389552(+) A-I      intronic chr2:231389585(+) A-I      intronic chr2:231383226(+) A-I      intronic chr2:231393678(+) A-I      intronic chr2:231397724(+) A-I      intronic chr2:231388474(+) A-I      intronic chr2:231387630(+) A-I      intronic chr2:231387604(+) A-I      intronic chr2:231387425(+) A-I      intronic chr2:231382290(+) A-I      intronic chr2:231388143(+) A-I      intronic chr2:231365779(+) A-I      intronic chr2:231365778(+) A-I      intronic chr2:231365771(+) A-I      intronic chr2:231387353(+) A-I      intronic chr2:231383258(+) A-I      intronic chr2:231389287(+) A-I      intronic chr2:231388132(+) A-I      intronic chr2:231388135(+) A-I      intronic chr2:231389291(+) A-I      intronic chr2:231389013(+) A-I      intronic chr2:231389006(+) A-I      intronic chr2:231389005(+) A-I      intronic chr2:231389003(+) A-I      intronic chr2:231388991(+) A-I      intronic chr2:231388980(+) A-I      intronic chr2:231388589(+) A-I      intronic chr2:231388544(+) A-I      intronic chr2:231388153(+) A-I      intronic chr2:231383248(+) A-I      intronic chr2:231383254(+) A-I      intronic chr2:231388423(+) A-I      intronic chr2:231393685(+) A-I      intronic chr2:231393717(+) A-I      intronic chr2:231393732(+) A-I      intronic chr2:231383469(+) A-I      intronic chr2:231383472(+) A-I      intronic chr2:231383488(+) A-I      intronic chr2:231388509(+) A-I      intronic chr2:231383489(+) A-I      intronic chr2:231383504(+) A-I      intronic chr2:231383512(+) A-I      intronic chr2:231389208(+) A-I      intronic chr2:231389218(+) A-I      intronic chr2:231388463(+) A-I      intronic chr2:231388466(+) A-I      intronic chr2:231393670(+) A-I      intronic chr2:231389220(+) A-I      intronic chr2:231389232(+) A-I      intronic chr2:231389237(+) A-I      intronic chr2:231393658(+) A-I      intronic chr2:231389238(+) A-I      intronic chr2:231389239(+) A-I      intronic chr2:231389256(+) A-I      intronic chr2:231389467(+) A-I      intronic chr2:231389258(+) A-I      intronic chr2:231389265(+) A-I      intronic chr2:231389271(+) A-I      intronic chr2:231389279(+) A-I      intronic chr2:231388167(+) A-I      intronic chr2:231388149(+) A-I      intronic chr2:231388148(+) A-I      intronic chr2:231388127(+) A-I      intronic chr2:231387766(+) A-I      intronic chr2:231387765(+) A-I      intronic chr2:231387752(+) A-I      intronic chr2:231387739(+) A-I      intronic chr2:231387710(+) A-I      intronic chr2:231387695(+) A-I      intronic chr2:231387679(+) A-I      intronic chr2:231387669(+) A-I      intronic chr2:231387663(+) A-I      intronic chr2:231387659(+) A-I      intronic chr2:231387656(+) A-I      intronic chr2:231387647(+) A-I      intronic chr2:231387483(+) A-I      intronic chr2:231387477(+) A-I      intronic chr2:231387464(+) A-I      intronic chr2:231387394(+) A-I      intronic chr2:231387388(+) A-I      intronic chr2:231387385(+) A-I      intronic chr2:231387365(+) A-I      intronic chr2:231387304(+) A-I      intronic chr2:231387284(+) A-I      intronic chr2:231387278(+) A-I      intronic chr2:231387268(+) A-I      intronic chr2:231387259(+) A-I      intronic chr2:231387247(+) A-I      intronic chr2:231387243(+) A-I      intronic chr2:231382388(+) A-I      intronic chr2:231382386(+) A-I      intronic chr2:231382334(+) A-I      intronic chr2:231382315(+) A-I      intronic chr2:231377255(+) A-I      intronic chr2:231377130(+) A-I      intronic chr2:231376694(+) A-I      intronic chr2:231376682(+) A-I      intronic chr2:231376681(+) A-I      intronic chr2:231376646(+) A-I      intronic chr2:231376603(+) A-I      intronic chr2:231366687(+) A-I      intronic chr2:231366683(+) A-I      intronic chr2:231365877(+) A-I      intronic chr2:231365867(+) A-I      intronic chr2:231360219(+) A-I      intronic chr2:231360195(+) A-I      intronic chr2:231360174(+) A-I      intronic chr2:231343669(+) A-I      intronic chr2:231343640(+) A-I      intronic chr2:231343636(+) A-I      intronic chr2:231342514(+) A-I      intronic chr2:231326680(+) A-I      intronic chr2:231326599(+) A-I      intronic chr2:231326430(+) A-I      intronic chr2:231326409(+) A-I      intronic chr2:231293419(+) A-I      intronic chr2:231293348(+) A-I      intronic chr2:231293339(+) A-I      intronic chr2:231293315(+) A-I      intronic chr2:231293297(+) A-I      intronic chr2:231293287(+) A-I      intronic chr2:231293275(+) A-I      intronic chr2:231293227(+) A-I      intronic chr2:231292902(+) A-I      intronic chr2:231292858(+) A-I      intronic chr2:231292850(+) A-I      intronic chr2:231292835(+) A-I      intronic chr2:231292705(+) A-I      intronic chr2:231292674(+) A-I      intronic chr2:231292668(+) A-I      intronic chr2:231292049(+) A-I      intronic chr2:231292042(+) A-I      intronic chr2:231292034(+) A-I      intronic chr2:231292018(+) A-I      intronic chr2:231292016(+) A-I      intronic chr2:231291981(+) A-I      intronic chr2:231291980(+) A-I      intronic chr2:231291977(+) A-I      intronic chr2:231366701(+) A-I      intronic chr2:231401949(+) A-I      intronic chr2:231401899(+) A-I      intronic chr2:231401894(+) A-I      intronic chr2:231401893(+) A-I      intronic chr2:231401859(+) A-I      intronic chr2:231401753(+) A-I      intronic chr2:231401745(+) A-I      intronic chr2:231401744(+) A-I      intronic chr2:231401723(+) A-I      intronic chr2:231400359(+) A-I      intronic chr2:231399078(+) A-I      intronic chr2:231398968(+) A-I      intronic chr2:231398967(+) A-I      intronic chr2:231398943(+) A-I      intronic chr2:231398922(+) A-I      intronic chr2:231398876(+) A-I      intronic chr2:231398867(+) A-I      intronic chr2:231397778(+) A-I      intronic chr2:231397770(+) A-I      intronic chr2:231397757(+) A-I      intronic chr2:231397679(+) A-I      intronic chr2:231397670(+) A-I      intronic chr2:231397662(+) A-I      intronic chr2:231397599(+) A-I      intronic chr2:231389050(+) A-I      intronic chr2:231389021(+) A-I      intronic chr2:231389020(+) A-I      intronic chr2:231388986(+) A-I      intronic chr2:231388983(+) A-I      intronic chr2:231388977(+) A-I      intronic chr2:231388964(+) A-I      intronic chr2:231388956(+) A-I      intronic chr2:231388951(+) A-I      intronic chr2:231388928(+) A-I      intronic chr2:231388924(+) A-I      intronic chr2:231388888(+) A-I      intronic chr2:231388887(+) A-I      intronic chr2:231388873(+) A-I      intronic chr2:231388863(+) A-I      intronic chr2:231388862(+) A-I      intronic chr2:231388808(+) A-I      intronic chr2:231388794(+) A-I      intronic chr2:231388793(+) A-I      intronic chr2:231388600(+) A-I      intronic chr2:231388599(+) A-I      intronic chr2:231388576(+) A-I      intronic chr2:231388569(+) A-I      intronic chr2:231388536(+) A-I      intronic chr2:231388533(+) A-I      intronic chr2:231388530(+) A-I      intronic chr2:231388526(+) A-I      intronic chr2:231388525(+) A-I      intronic chr2:231388517(+) A-I      intronic chr2:231388504(+) A-I      intronic chr2:231388501(+) A-I      intronic chr2:231388485(+) A-I      intronic chr2:231388477(+) A-I      intronic chr2:231388473(+) A-I      intronic chr2:231388472(+) A-I      intronic chr2:231388465(+) A-I      intronic chr2:231388464(+) A-I      intronic chr2:231388462(+) A-I      intronic chr2:231388374(+) A-I      intronic chr2:231388172(+) A-I      intronic chr2:231399033(+) A-I      intronic chr2:231376661(+) A-I      intronic chr2:231398859(+) A-I      intronic chr2:231398868(+) A-I      intronic chr2:231376850(+) A-I      intronic chr2:231398950(+) A-I      intronic chr2:231399010(+) A-I      intronic chr2:231398970(+) A-I      intronic chr2:231366637(+) A-I      intronic chr2:231376633(+) A-I      intronic chr2:231398971(+) A-I      intronic chr2:231398935(+) A-I      intronic chr2:231389019(+) A-I      intronic chr2:231398964(+) A-I      intronic chr2:231387321(+) A-I      intronic chr2:231388369(+) A-I      intronic chr2:231292799(+) A-I      intronic chr2:231397576(+) A-I      intronic chr2:231376630(+) A-I      intronic chr2:231376601(+) A-I      intronic chr2:231333545(+) A-I      intronic chr2:231293232(+) A-I      intronic chr2:231398956(+) A-I      intronic chr2:231398994(+) A-I      intronic chr2:231399023(+) A-I      intronic chr2:231388414(+) A-I      intronic chr2:231388568(+) A-I      intronic chr2:231342530(+) A-I      intronic chr2:231376605(+) A-I      intronic chr2:231292886(+) A-I      intronic chr2:231377144(+) A-I      intronic chr2:231365703(+) A-I      intronic chr2:231397625(+) A-I      intronic chr2:231341685(+) A-I      intronic chr2:231330740(+) A-I      intronic chr2:231387343(+) A-I      intronic chr2:231382271(+) A-I      intronic chr2:231387345(+) A-I      intronic chr2:231357957(+) A-I      intronic chr2:231397758(+) A-I      intronic chr2:231292861(+) A-I      intronic chr2:231293431(+) A-I      intronic chr2:231382359(+) A-I      intronic chr2:231341674(+) A-I      intronic chr2:231387257(+) A-I      intronic chr2:231375248(+) A-I      intronic chr2:231399006(+) A-I      intronic chr2:231382369(+) A-I      intronic chr2:231343600(+) A-I      intronic chr2:231342527(+) A-I      intronic chr2:231387370(+) A-I      intronic chr2:231388438(+) A-I      intronic chr2:231398974(+) A-I      intronic chr2:231293364(+) A-I      intronic chr2:231341714(+) A-I      intronic chr2:231376765(+) A-I      intronic chr2:231387465(+) A-I      intronic chr2:231382408(+) A-I      intronic chr2:231382333(+) A-I      intronic chr2:231397596(+) A-I      intronic chr2:231292736(+) A-I      intronic chr2:231366688(+) A-I      intronic chr2:231376711(+) A-I      intronic chr2:231382419(+) A-I      intronic chr2:231333337(+) A-I      intronic chr2:231388124(+) A-I      intronic chr2:231366632(+) A-I      intronic chr2:231382206(+) A-I      intronic chr2:231376856(+) A-I      intronic chr2:231376651(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SP100	chr2:231377610(+) A-I intron -    22327324 chr2:231387257(+) A-I intron -    22327324 chr2:231388568(+) A-I intron -    22327324 chr2:231389250(+) A-I intron -    22327324 chr2:231389470(+) A-I intron -    22327324 chr2:231389580(+) A-I intron -    22327324 chr2:231389584(+) A-I intron -    22327324 chr2:231389587(+) A-I intron -    22327324 chr2:231389592(+) A-I intron -    22327324 chr2:231397596(+) A-I intron -    22327324 chr2:231398974(+) A-I intron -    22028664   //22327324 chr2:231399000(+) A-I intron -    22028664   //22327324 chr2:231398859(+) A-I intron -    22028664 chr2:231398868(+) A-I intron -    22028664 chr2:231398935(+) A-I intron -    22028664 chr2:231398950(+) A-I intron -    22028664 chr2:231398956(+) A-I intron -    22028664 chr2:231398964(+) A-I intron -    22028664 chr2:231398970(+) A-I intron -    22028664 chr2:231398971(+) A-I intron -    22028664 chr2:231398994(+) A-I intron -    22028664 chr2:231399010(+) A-I intron -    22028664 chr2:231399023(+) A-I intron -    22028664 chr2:231399033(+) A-I intron -    22028664 chr2:231378559(+) A-I intron -    21960545 chr2:231378565(+) A-I intron -    21960545 chr2:231381523(+) A-I intron -    21960545 chr2:231382827(+) A-I intron -    21960545 chr2:231383447(+) A-I intron -    21960545 chr2:231383512(+) A-I intron -    21960545 chr2:231350947(+) C-T intron -    22484847 chr2:231377610(+) A-G intron -    22484847 chr2:231378559(+) A-G intron -    22484847 chr2:231292060(+) A-G intron -    22484847 chr2:231292691(+) A-G intron -    22484847 chr2:231292736(+) A-G intron -    22484847 chr2:231292760(+) A-G intron -    22484847 chr2:231292799(+) A-G intron -    22484847 chr2:231292825(+) A-G intron -    22484847 chr2:231292861(+) A-G intron -    22484847 chr2:231292886(+) A-G intron -    22484847 chr2:231292894(+) A-G intron -    22484847 chr2:231293364(+) A-G intron -    22484847 chr2:231293431(+) A-G intron -    22484847 chr2:231329644(+) C-T intron -    22484847 chr2:231329756(+) T-G intron -    22484847 chr2:231337142(+) C-A intron -    22484847 chr2:231341654(+) T-C intron -    22484847 chr2:231341674(+) A-G intron -    22484847 chr2:231341685(+) A-G intron -    22484847 chr2:231341714(+) A-G intron -    22484847 chr2:231342527(+) A-G intron -    22484847 chr2:231342529(+) A-G intron -    22484847 chr2:231342530(+) A-G intron -    22484847 chr2:231343600(+) A-G intron -    22484847 chr2:231357957(+) A-G intron -    22484847 chr2:231365696(+) A-G intron -    22484847 chr2:231365703(+) A-G intron -    22484847 chr2:231365834(+) A-G intron -    22484847 chr2:231365836(+) A-G intron -    22484847 chr2:231366632(+) A-G intron -    22484847 chr2:231366637(+) A-G intron -    22484847 chr2:231366688(+) A-G intron -    22484847 chr2:231376601(+) A-G intron -    22484847 chr2:231376605(+) A-G intron -    22484847 chr2:231376630(+) A-G intron -    22484847 chr2:231376633(+) A-G intron -    22484847 chr2:231376651(+) A-G intron -    22484847 chr2:231376661(+) A-G intron -    22484847 chr2:231376711(+) A-G intron -    22484847 chr2:231376789(+) C-T intron -    22484847 chr2:231376850(+) A-G intron -    22484847 chr2:231377144(+) A-G intron -    22484847 chr2:231377246(+) A-C intron -    22484847 chr2:231382206(+) A-G intron -    22484847 chr2:231382208(+) A-G intron -    22484847 chr2:231382271(+) A-G intron -    22484847 chr2:231382333(+) A-G intron -    22484847 chr2:231382359(+) A-G intron -    22484847 chr2:231382408(+) A-G intron -    22484847 chr2:231382419(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SP100	chr2:231305239-231305240(+) m6A 5'UTR//intron       24209618 chr2:231305266-231305267(+) m6A 5'UTR//intron       24209618 chr2:231307665-231307666(+) m6A CDS       24209618 chr2:231314263-231314264(+) m6A exon//intron       24981863 chr2:231314297-231314298(+) m6A CDS//exon       24981863 chr2:231314319-231314320(+) m6A CDS//exon       24981863 chr2:231314324-231314325(+) m6A CDS//exon       24981863 chr2:231314388-231314389(+) m6A CDS//exon       24981863 chr2:231314396-231314397(+) m6A CDS//exon       24981863 chr2:231314896-231314897(+) m6A CDS//exon       24981863 chr2:231338124-231338125(+) m6A CDS//exon       24981863 chr2:231339126-231339127(+) m6A CDS//exon       24981863//27773535 chr2:231339145-231339146(+) m6A CDS//exon       24981863//27773535 chr2:231358530-231358531(+) m6A exon//intron       24981863//27773535 chr2:231358602-231358603(+) m6A exon//intron       24981863 chr2:231358619-231358620(+) m6A exon//intron       24981863 chr2:231363187-231363188(+) m6A CDS//exon       24981863//27773535 chr2:231363200-231363201(+) m6A CDS//exon       24981863//27773535 chr2:231367799-231367800(+) m6A CDS       24981863//27773535 chr2:231369000-231369001(+) m6A CDS//exon       24981863 chr2:231371019-231371020(+) m6A CDS//exon       24981863 chr2:231379800-231379801(+) m6A intron       - chr2:231379828-231379829(+) m6A CDS//intron       - chr2:231379887-231379888(+) m6A CDS//intron       24981863 chr2:231379936-231379937(+) m6A CDS//intron       24981863 chr2:231380120-231380121(+) m6A CDS//intron       - chr2:231380318-231380319(+) m6A CDS//intron       24981863//27773535 chr2:231380435-231380436(+) m6A 3'UTR//intron       24981863 chr2:231380448-231380449(+) m6A 3'UTR//intron       24981863 chr2:231380470-231380471(+) m6A 3'UTR//intron       24981863 chr2:231407749-231407750(+) m6A 3'UTR//exon       24981863 chr2:231407793-231407794(+) m6A 3'UTR//exon       24981863 chr2:231408540-231408541(+) m6A 3'UTR//exon       24981863 chr2:231408585-231408586(+) m6A 3'UTR//exon       24981863 chr2:231408619-231408620(+) m6A 3'UTR//exon       24981863 chr2:231408647-231408648(+) m6A 3'UTR//exon       24981863 chr2:231408684-231408685(+) m6A 3'UTR//exon       24981863 chr2:231408693-231408694(+) m6A 3'UTR//exon       24981863 chr2:231408717-231408718(+) m6A 3'UTR//exon       24981863 chr2:231408752-231408753(+) m6A 3'UTR//exon       24981863 chr2:231408770-231408771(+) m6A 3'UTR//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1976	Cytoplasm Cell line (HeLa)     21695135 Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     - Mitochondrion Skeletal muscle cells     27563705
	SP100	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-1976	Gemcitabine 60750 Drug interaction    RC00007973 5-Fluorouracil 3385 Drug interaction    RC00007972

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-1976	Panobinostat       6918837 Paclitaxel       36314

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1976
Interactor2: SP100

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.