Detail Information

Basic Information:


  VIRBase ID:  

HHID00071577

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1976:           EIF3E:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1976 EIF3E
miRBase
Accession/Entrez ID		 MIMAT0009451 3646
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - eIF3-p46//EIF3-P48//EIF3S6//INT6

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-1976
rs1173366847 chr1:26554586    C/T
rs1208235584 chr1:26554592    G/A
rs985342579 chr1:26554590    C/T
rs1478358767 chr1:26554578    C/T
rs765589931 chr1:26554577    C/G
rs972150493 chr1:26554576    T/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR EIF3E
chr8:109238581(-) A-I      intronic
chr8:109238600(-) A-I      intronic
chr8:109246479(-) A-I      intronic
chr8:109232290(-) A-I      intronic
chr8:109238547(-) A-I      intronic
chr8:109231209(-) A-I      intronic
chr8:109231018(-) A-I      intronic
chr8:109231080(-) A-I      intronic
chr8:109231141(-) A-I      intronic
chr8:109231145(-) A-I      intronic
chr8:109238603(-) A-I      intronic
chr8:109231265(-) A-I      intronic
chr8:109239351(-) A-I      intronic
chr8:109239337(-) A-I      intronic
chr8:109238602(-) A-I      intronic
chr8:109249034(-) A-I      intronic
chr8:109249094(-) A-I      intronic
chr8:109249534(-) A-I      intronic
chr8:109231228(-) A-I      intronic
chr8:109249006(-) A-I      intronic
chr8:109249007(-) A-I      intronic
chr8:109249592(-) A-I      intronic
chr8:109249645(-) A-I      intronic
chr8:109249657(-) A-I      intronic
chr8:109249754(-) A-I      intronic
chr8:109232206(-) A-I      intronic
chr8:109239336(-) A-I      intronic
chr8:109239333(-) A-I      intronic
chr8:109238662(-) A-I      intronic
chr8:109238643(-) A-I      intronic
chr8:109249737(-) A-I      intronic
chr8:109238534(-) A-I      intronic
chr8:109238520(-) A-I      intronic
chr8:109238490(-) A-I      intronic
chr8:109238465(-) A-I      intronic
chr8:109234428(-) A-I      intronic
chr8:109233495(-) A-I      intronic
chr8:109239431(-) A-I      intronic
chr8:109238606(-) A-I      intronic
chr8:109232215(-) A-I      intronic
chr8:109249659(-) A-I      intronic
chr8:109231177(-) A-I      intronic
chr8:109245813(-) A-I      intronic
chr8:109231144(-) A-I      intronic
chr8:109238612(-) A-I      intronic
chr8:109257638(-) A-I      intronic
chr8:109231985(-) A-I      intronic
chr8:109246399(-) A-I      intronic
chr8:109246431(-) A-I      intronic
chr8:109257651(-) A-I      intronic
chr8:109232347(-) A-I      intronic
chr8:109231216(-) A-I      intronic
chr8:109246426(-) A-I      intronic
chr8:109231908(-) A-I      intronic
chr8:109249660(-) A-I      intronic
chr8:109239444(-) A-I      intronic
chr8:109234403(-) A-I      intronic
chr8:109249543(-) A-I      intronic
chr8:109249168(-) A-I      intronic
chr8:109249675(-) A-I      intronic
chr8:109233127(-) A-I      intronic
chr8:109232250(-) A-I      intronic
chr8:109231084(-) A-I      intronic
chr8:109232289(-) A-I      intronic
chr8:109249194(-) A-I      intronic
chr8:109249175(-) A-I      intronic
chr8:109246329(-) A-I      intronic
chr8:109233422(-) A-I      intronic
chr8:109249085(-) A-I      intronic
chr8:109251522(-) A-I      intronic
chr8:109231218(-) A-I      intronic
chr8:109231884(-) A-I      intronic
chr8:109239382(-) A-I      intronic
chr8:109231101(-) A-I      intronic
chr8:109232200(-) A-I      intronic
chr8:109224993(-) A-I      intronic
chr8:109231151(-) A-I      intronic
chr8:109249618(-) A-I      intronic
chr8:109245949(-) A-I      intronic
chr8:109239470(-) A-I      intronic
chr8:109249514(-) A-I      intronic
chr8:109239491(-) A-I      intronic
chr8:109239445(-) A-I      intronic
chr8:109249753(-) A-I      intronic
chr8:109232303(-) A-I      intronic
chr8:109249619(-) A-I      intronic
chr8:109249059(-) A-I      intronic
chr8:109249151(-) A-I      intronic
chr8:109234343(-) A-I      intronic
chr8:109238698(-) A-I      intronic
chr8:109234314(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED EIF3E
chr8:109231101(-) A-G intron -    22484847
chr8:109231151(-) A-G intron -    22484847
chr8:109231216(-) A-G intron -    22484847
chr8:109231287(-) A-G intron -    22484847
chr8:109231888(-) A-G intron -    22484847
chr8:109231908(-) A-G intron -    22484847
chr8:109232289(-) A-G intron -    22484847
chr8:109232303(-) A-G intron -    22484847
chr8:109232374(-) G-T intron -    22484847
chr8:109249059(-) A-G intron -    22484847
chr8:109249071(-) A-G intron -    22484847
chr8:109249085(-) A-G intron -    22484847
chr8:109249088(-) A-G intron -    22484847
chr8:109249151(-) A-G intron -    22484847
chr8:109249168(-) A-G intron -    22484847
chr8:109249175(-) A-G intron -    22484847
chr8:109249245(-) A-G intron -    22484847
chr8:109249659(-) A-G intron -    22484847
chr8:109249660(-) A-G intron -    22484847
chr8:109249675(-) A-G intron -    22484847
chr8:109249732(-) A-G intron -    22484847
chr8:109249753(-) A-G intron -    22484847
chr8:109249767(-) A-G intron -    22484847
chr8:109253183(-) G-A intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase EIF3E
chr8:109213705-109213706(-) m6A exon       27773535
chr8:109214023-109214024(-) m6A 3'UTR//exon       24981863//28052920//27773535//22608085
chr8:109214056-109214057(-) m6A 3'UTR//exon       24981863//28052920//27773535//22608085
chr8:109214083-109214084(-) m6A 3'UTR//exon       24981863//28052920//27773535//22608085
chr8:109214109-109214110(-) m6A 3'UTR//exon       24981863//27773535
chr8:109215235-109215236(-) m6A CDS//exon       24981863//27773535
chr8:109215288-109215289(-) m6A CDS//exon       24981863
chr8:109228722-109228723(-) m6A CDS//exon//intron       26404942
chr8:109229620-109229621(-) m6A 3'UTR//CDS//exon//intron       26404942
chr8:109229669-109229670(-) m6A 3'UTR//CDS//exon//intron       26404942
chr8:109233728-109233729(-) m6A exon//intron       26404942
chr8:109240583-109240584(-) m6A 3'UTR//CDS//exon       27773535
chr8:109241312-109241313(-) m6A 3'UTR//CDS//exon       27773535
chr8:109241320-109241321(-) Y 3'UTR//CDS//exon       26075521
chr8:109241332-109241333(-) m6A 3'UTR//CDS//exon       -
chr8:109255686-109255687(-) m6A 5'UTR//intron       24981863
chr8:109260950-109260951(-) m6A 5'UTR//exon//intron       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-1976
Cytoplasm Cell line (HeLa)     21695135
Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
Mitochondrion Skeletal muscle cells     27563705
EIF3E
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Membrane K562 cells     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome-free cytosol Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-1976
Gemcitabine 60750 Drug interaction    RC00007973
5-Fluorouracil 3385 Drug interaction    RC00007972
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-1976
Panobinostat       6918837
Paclitaxel       36314

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1976
Interactor2: EIF3E

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region CDS
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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