Basic Information:

  VIRBase ID:  

HHID00071576

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1976:  MIMAT0009451          HSPA4:  NM_002154     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1976	HSPA4
miRBase Accession/Entrez ID	MIMAT0009451	3308
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	APG-2//HEL-S-5a//HS24/P52//hsp70//hsp70RY//HSPH2//RY

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1976	rs1173366847 chr1:26554586    C/T rs1208235584 chr1:26554592    G/A rs985342579 chr1:26554590    C/T rs1478358767 chr1:26554578    C/T rs765589931 chr1:26554577    C/G rs972150493 chr1:26554576    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	HSPA4	chr5:132419273(+) A-I      intronic chr5:132418677(+) A-I      intronic chr5:132421805(+) A-I      intronic chr5:132421797(+) A-I      intronic chr5:132421780(+) A-I      intronic chr5:132421280(+) A-I      intronic chr5:132421272(+) A-I      intronic chr5:132391623(+) A-I      intronic chr5:132413173(+) A-I      intronic chr5:132413191(+) A-I      intronic chr5:132413864(+) A-I      intronic chr5:132414150(+) A-I      intronic chr5:132421095(+) A-I      intronic chr5:132420710(+) A-I      intronic chr5:132420593(+) A-I      intronic chr5:132414261(+) A-I      intronic chr5:132420414(+) A-I      intronic chr5:132414268(+) A-I      intronic chr5:132414452(+) A-I      intronic chr5:132414465(+) A-I      intronic chr5:132414525(+) A-I      intronic chr5:132414555(+) A-I      intronic chr5:132414591(+) A-I      intronic chr5:132415899(+) A-I      intronic chr5:132415922(+) A-I      intronic chr5:132416062(+) A-I      intronic chr5:132416783(+) A-I      intronic chr5:132416901(+) A-I      intronic chr5:132418662(+) A-I      intronic chr5:132420382(+) A-I      intronic chr5:132420347(+) A-I      intronic chr5:132429656(+) A-I      intronic chr5:132429664(+) A-I      intronic chr5:132429674(+) A-I      intronic chr5:132407085(+) A-I      intronic chr5:132407095(+) A-I      intronic chr5:132416840(+) A-I      intronic chr5:132391676(+) A-I      intronic chr5:132407097(+) A-I      intronic chr5:132410097(+) A-I      intronic chr5:132410110(+) A-I      intronic chr5:132412995(+) A-I      intronic chr5:132413000(+) A-I      intronic chr5:132416940(+) A-I      intronic chr5:132418283(+) A-I      intronic chr5:132418323(+) A-I      intronic chr5:132418343(+) A-I      intronic chr5:132418550(+) A-I      intronic chr5:132418643(+) A-I      intronic chr5:132420263(+) A-I      intronic chr5:132421856(+) A-I      intronic chr5:132429598(+) A-I      intronic chr5:132429599(+) A-I      intronic chr5:132413047(+) A-I      intronic chr5:132419457(+) A-I      intronic chr5:132421098(+) A-I      intronic chr5:132419438(+) A-I      intronic chr5:132429623(+) A-I      intronic chr5:132430786(+) A-I      intronic chr5:132430926(+) A-I      intronic chr5:132436259(+) A-I      intronic chr5:132436321(+) A-I      intronic chr5:132436759(+) A-I      intronic chr5:132429670(+) A-I      intronic chr5:132414175(+) A-I      intronic chr5:132414207(+) A-I      intronic chr5:132421142(+) A-I      intronic chr5:132421143(+) A-I      intronic chr5:132390024(+) A-I      intronic chr5:132390031(+) A-I      intronic chr5:132391560(+) A-I      intronic chr5:132391672(+) A-I      intronic chr5:132391691(+) A-I      intronic chr5:132391698(+) A-I      intronic chr5:132392224(+) A-I      intronic chr5:132393106(+) A-I      intronic chr5:132393855(+) A-I      intronic chr5:132394098(+) A-I      intronic chr5:132394223(+) A-I      intronic chr5:132395162(+) A-I      intronic chr5:132395182(+) A-I      intronic chr5:132396940(+) A-I      intronic chr5:132396941(+) A-I      intronic chr5:132398845(+) A-I      intronic chr5:132399920(+) A-I      intronic chr5:132400027(+) A-I      intronic chr5:132400077(+) A-I      intronic chr5:132400108(+) A-I      intronic chr5:132405601(+) A-I      intronic chr5:132405647(+) A-I      intronic chr5:132405708(+) A-I      intronic chr5:132405840(+) A-I      intronic chr5:132406415(+) A-I      intronic chr5:132406474(+) A-I      intronic chr5:132414248(+) A-I      intronic chr5:132415919(+) A-I      intronic chr5:132389491(+) A-I      intronic chr5:132421115(+) A-I      intronic chr5:132405628(+) A-I      intronic chr5:132396184(+) A-I      intronic chr5:132408220(+) A-I      intronic chr5:132421179(+) A-I      intronic chr5:132416035(+) A-I      intronic chr5:132406957(+) A-I      intronic chr5:132399399(+) A-I      intronic chr5:132436023(+) A-I      intronic chr5:132413192(+) A-I      intronic chr5:132428785(+) A-I      intronic chr5:132418358(+) A-I      intronic chr5:132389958(+) A-I      intronic chr5:132414635(+) A-I      intronic chr5:132418906(+) A-I      intronic chr5:132418680(+) A-I      intronic chr5:132411463(+) A-I      intronic chr5:132413204(+) A-I      intronic chr5:132405195(+) A-I      intronic chr5:132414647(+) A-I      intronic chr5:132416022(+) A-I      intronic chr5:132414059(+) A-I      intronic chr5:132419412(+) A-I      intronic chr5:132419286(+) A-I      intronic chr5:132405177(+) A-I      intronic chr5:132408319(+) A-I      intronic chr5:132412992(+) A-I      intronic chr5:132415920(+) A-I      intronic chr5:132415927(+) A-I      intronic chr5:132414223(+) A-I      intronic chr5:132436324(+) A-I      intronic chr5:132399593(+) A-I      intronic chr5:132436006(+) A-I      intronic chr5:132406473(+) A-I      intronic chr5:132400036(+) A-I      intronic chr5:132413769(+) A-I      intronic chr5:132391608(+) A-I      intronic chr5:132405042(+) A-I      intronic chr5:132418415(+) A-I      intronic chr5:132393971(+) A-I      intronic chr5:132394673(+) A-I      intronic chr5:132389620(+) A-I      intronic chr5:132438804(+) A-I      intronic chr5:132411375(+) A-I      intronic chr5:132405108(+) A-I      intronic chr5:132420436(+) A-I      intronic chr5:132393870(+) A-I      intronic chr5:132411461(+) A-I      intronic chr5:132400119(+) A-I      intronic chr5:132429293(+) A-I      intronic chr5:132419355(+) A-I      intronic chr5:132414247(+) A-I      intronic chr5:132429226(+) A-I      intronic chr5:132414310(+) A-I      intronic chr5:132394035(+) A-I      intronic chr5:132400078(+) A-I      intronic chr5:132395225(+) A-I      intronic chr5:132398888(+) A-I      intronic chr5:132412994(+) A-I      intronic chr5:132435922(+) A-I      intronic chr5:132393151(+) A-I      intronic chr5:132429372(+) A-I      intronic chr5:132400033(+) A-I      intronic chr5:132411401(+) A-I      intronic chr5:132418723(+) A-I      intronic chr5:132415996(+) A-I      intronic chr5:132436294(+) A-I      intronic chr5:132418284(+) A-I      intronic chr5:132412984(+) A-I      intronic chr5:132436760(+) A-I      intronic chr5:132421857(+) A-I      intronic chr5:132394335(+) A-I      intronic chr5:132411369(+) A-I      intronic chr5:132391744(+) A-I      intronic chr5:132391617(+) A-I      intronic chr5:132418733(+) A-I      intronic chr5:132418811(+) A-I      intronic chr5:132413903(+) A-I      intronic chr5:132418270(+) A-I      intronic chr5:132391659(+) A-I      intronic chr5:132429348(+) A-I      intronic chr5:132429691(+) A-I      intronic chr5:132436327(+) A-I      intronic chr5:132416869(+) A-I      intronic chr5:132423599(+) A-I      intronic chr5:132429638(+) A-I      intronic chr5:132421796(+) A-I      intronic chr5:132430740(+) A-I      intronic chr5:132429300(+) A-I      intronic chr5:132405171(+) A-I      intronic chr5:132414592(+) A-I      intronic chr5:132414180(+) A-I      intronic chr5:132430748(+) A-I      intronic chr5:132429213(+) A-I      intronic chr5:132430787(+) A-I      intronic chr5:132418427(+) A-I      intronic chr5:132421273(+) A-I      intronic chr5:132436631(+) A-I      intronic chr5:132416920(+) A-I      intronic chr5:132405716(+) A-I      intronic chr5:132413034(+) A-I      intronic chr5:132415928(+) A-I      intronic chr5:132417477(+) A-I      intronic chr5:132414124(+) A-I      intronic chr5:132428791(+) A-I      intronic chr5:132418421(+) A-I      intronic chr5:132428784(+) A-I      intronic chr5:132418656(+) A-I      intronic chr5:132415986(+) A-I      intronic chr5:132429632(+) A-I      intronic chr5:132429236(+) A-I      intronic chr5:132408198(+) A-I      intronic chr5:132399412(+) A-I      intronic chr5:132414174(+) A-I      intronic chr5:132398847(+) A-I      intronic chr5:132414623(+) A-I      intronic chr5:132419310(+) A-I      intronic chr5:132405748(+) A-I      intronic chr5:132408153(+) A-I      intronic chr5:132414107(+) A-I      intronic chr5:132435917(+) A-I      intronic chr5:132420639(+) A-I      intronic chr5:132420666(+) A-I      intronic chr5:132399046(+) A-I      intronic chr5:132436326(+) A-I      intronic chr5:132421106(+) A-I      intronic chr5:132418219(+) A-I      intronic chr5:132429366(+) A-I      intronic chr5:132415856(+) A-I      intronic chr5:132419491(+) A-I      intronic chr5:132430742(+) A-I      intronic chr5:132421134(+) A-I      intronic chr5:132418360(+) A-I      intronic chr5:132426078(+) A-I      intronic chr5:132414162(+) A-I      intronic chr5:132418208(+) A-I      intronic chr5:132416905(+) A-I      intronic chr5:132413030(+) A-I      intronic chr5:132399716(+) A-I      intronic chr5:132418222(+) A-I      intronic chr5:132394430(+) A-I      intronic chr5:132405697(+) A-I      intronic chr5:132429631(+) A-I      intronic chr5:132428757(+) A-I      intronic chr5:132391501(+) A-I      intronic chr5:132429312(+) A-I      intronic chr5:132405643(+) A-I      intronic chr5:132418275(+) A-I      intronic chr5:132436758(+) A-I      intronic chr5:132413877(+) A-I      intronic chr5:132413770(+) A-I      intronic chr5:132418925(+) A-I      intronic chr5:132400012(+) A-I      intronic chr5:132394533(+) A-I      intronic chr5:132429554(+) A-I      intronic chr5:132421158(+) A-I      intronic chr5:132413150(+) A-I      intronic chr5:132418414(+) A-I      intronic chr5:132414609(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	HSPA4	chr5:132417938(+) A-I intron -    21960545 chr5:132418182(+) A-I intron -    21960545 chr5:132418189(+) A-I intron -    21960545 chr5:132436631(+) A-I intron -    21960545 chr5:132389620(+) A-G intron -    22484847 chr5:132391501(+) A-G intron -    22484847 chr5:132393151(+) A-G intron -    22484847 chr5:132394035(+) A-G intron -    22484847 chr5:132398888(+) A-G intron -    22484847 chr5:132400012(+) A-G intron -    22484847 chr5:132400033(+) A-G intron -    22484847 chr5:132400036(+) A-G intron -    22484847 chr5:132400078(+) A-G intron -    22484847 chr5:132405042(+) A-G intron -    22484847 chr5:132405108(+) A-G intron -    22484847 chr5:132405171(+) A-G intron -    22484847 chr5:132405177(+) A-G intron -    22484847 chr5:132405195(+) A-G intron -    22484847 chr5:132405205(+) A-G intron -    22484847 chr5:132405697(+) A-G intron -    22484847 chr5:132405716(+) A-G intron -    22484847 chr5:132408198(+) A-G intron -    22484847 chr5:132408319(+) A-G intron -    22484847 chr5:132411544(+) G-T intron -    22484847 chr5:132412984(+) A-G intron -    22484847 chr5:132412992(+) A-G intron -    22484847 chr5:132412994(+) A-G intron -    22484847 chr5:132413033(+) G-A intron -    22484847 chr5:132413150(+) A-G intron -    22484847 chr5:132413770(+) A-G intron -    22484847 chr5:132413903(+) A-G intron -    22484847 chr5:132414592(+) A-G intron -    22484847 chr5:132414609(+) A-G intron -    22484847 chr5:132414635(+) A-G intron -    22484847 chr5:132415927(+) A-G intron -    22484847 chr5:132415928(+) A-G intron -    22484847 chr5:132415986(+) A-G intron -    22484847 chr5:132416763(+) A-G intron -    22484847 chr5:132416801(+) A-G intron -    22484847 chr5:132416869(+) A-G intron -    22484847 chr5:132418189(+) A-G intron -    22484847 chr5:132418421(+) A-G intron -    22484847 chr5:132418656(+) A-G intron -    22484847 chr5:132418680(+) A-G intron -    22484847 chr5:132419286(+) A-G intron -    22484847 chr5:132419310(+) A-G intron -    22484847 chr5:132419355(+) A-G intron -    22484847 chr5:132419359(+) A-G intron -    22484847 chr5:132419463(+) A-G intron -    22484847 chr5:132420256(+) A-G intron -    22484847 chr5:132421273(+) A-G intron -    22484847 chr5:132429226(+) A-G intron -    22484847 chr5:132429236(+) A-G intron -    22484847 chr5:132429283(+) A-G intron -    22484847 chr5:132429300(+) A-G intron -    22484847 chr5:132429312(+) A-G intron -    22484847 chr5:132429348(+) A-G intron -    22484847 chr5:132429366(+) A-G intron -    22484847 chr5:132429372(+) A-G intron -    22484847 chr5:132429631(+) A-G intron -    22484847 chr5:132429632(+) A-G intron -    22484847 chr5:132429638(+) A-G intron -    22484847 chr5:132429654(+) A-G intron -    22484847 chr5:132430740(+) A-G intron -    22484847 chr5:132430742(+) A-G intron -    22484847 chr5:132430787(+) A-G intron -    22484847 chr5:132433501(+) G-A intron -    22484847 chr5:132435921(+) A-G intron -    22484847 chr5:132435922(+) A-G intron -    22484847 chr5:132436326(+) A-G intron -    22484847 chr5:132436327(+) A-G intron -    22484847 chr5:132436330(+) A-G intron -    22484847 chr5:132436631(+) A-G intron -    22484847 chr5:132436760(+) A-G intron -    22484847 chr5:132438603(+) G-T intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	HSPA4	chr5:132387800-132387801(+) m6A 5'UTR       24284625//24981863//22575960 chr5:132387818-132387819(+) m6A 5'UTR       24284625//24981863//22575960 chr5:132387909-132387910(+) m6A 5'UTR       22575960 chr5:132387961-132387962(+) m6A CDS       22575960 chr5:132388014-132388015(+) m6A CDS       22575960 chr5:132403127-132403128(+) m6A CDS       26404942 chr5:132409736-132409737(+) m6A CDS//intron       - chr5:132409759-132409760(+) m6A CDS//intron       - chr5:132409811-132409812(+) m6A CDS//intron       - chr5:132412579-132412580(+) m6A CDS//exon//intron       22575960 chr5:132422542-132422543(+) m6A CDS//exon//intron       22575960 chr5:132424192-132424193(+) m6A CDS//intron       26404942 chr5:132427039-132427040(+) m6A 3'UTR//CDS//intron       24981863//27773535 chr5:132427040-132427041(+) Cm 3'UTR//CDS//intron       - chr5:132428404-132428405(+) m6A 3'UTR//CDS//intron       24981863//27773535//27371828 chr5:132428414-132428415(+) m6A 3'UTR//CDS//intron       24981863//27773535//27371828 chr5:132428442-132428443(+) m6A 3'UTR//CDS//intron       24981863//27773535//27371828 chr5:132431823-132431824(+) m6A 3'UTR//CDS//intron       24981863//26404942//27773535 chr5:132431858-132431859(+) m6A 3'UTR//CDS//intron       24981863//26404942//27773535 chr5:132431871-132431872(+) m6A 3'UTR//CDS//intron       24981863//26404942//27773535 chr5:132431907-132431908(+) m6A 3'UTR//CDS//intron       24981863//26404942//27773535//22575960 chr5:132432875-132432876(+) m6A 3'UTR//CDS//intron       24981863//26404942//27773535//22575960 chr5:132432937-132432938(+) m6A 3'UTR//CDS//intron       24981863//26404942//27773535//22575960 chr5:132435259-132435260(+) m6A 3'UTR//CDS//intron       24981863//26404942//27773535//22575960 chr5:132435300-132435301(+) m6A 3'UTR//CDS//intron       24981863//26404942//27773535//22575960 chr5:132437515-132437516(+) m6A 3'UTR//CDS//exon//intron       24981863//27773535//22575960 chr5:132437524-132437525(+) m6A 3'UTR//CDS//exon//intron       24981863//27773535//22575960 chr5:132437565-132437566(+) m6A 3'UTR//CDS//exon//intron       24981863//26404942//27773535//22575960 chr5:132439560-132439561(+) m6A 3'UTR//CDS//exon//intron       24981863//26404942//27773535//22575960 chr5:132439656-132439657(+) m6A CDS//exon//intron       24284625//24981863//26404942//27773535//22575960 chr5:132439965-132439966(+) m6A CDS//exon//intron       24284625//24981863//26404942//27773535//22608085 chr5:132439977-132439978(+) m6A CDS//exon//intron       24284625//24981863//26404942//27773535//22608085 chr5:132439992-132439993(+) m6A CDS//exon//intron       24284625//25456834//24981863//26404942//27773535//22608085 chr5:132440016-132440017(+) m6A CDS//exon       24284625//25456834//24981863//26404942//27773535//22608085 chr5:132440028-132440029(+) m6A CDS//exon       24284625//25456834//24981863//26404942//27773535//22608085 chr5:132440036-132440037(+) m6A CDS//exon       24284625//25456834//24981863//26404942//27773535//22608085 chr5:132440072-132440073(+) m6A CDS//exon       24284625//25456834//24981863//27773535//22608085 chr5:132440096-132440097(+) m6A CDS//exon       24284625//25456834//24981863//27773535//22575960//22608085 chr5:132440117-132440118(+) m6A CDS//exon       24284625//25456834//24981863//27773535//22575960//22608085 chr5:132440151-132440152(+) m6A 3'UTR//exon       24284625//25456834//24981863//27773535//22575960//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1976	Cytoplasm Cell line (HeLa)     21695135 Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     - Mitochondrion Skeletal muscle cells     27563705
	HSPA4	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-1976	Gemcitabine 60750 Drug interaction    RC00007973 5-Fluorouracil 3385 Drug interaction    RC00007972

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-1976	Panobinostat       6918837 Paclitaxel       36314

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1976
Interactor2: HSPA4

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.