Basic Information:

  VIRBase ID:  

HHID00066015

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-186-3p:  MIMAT0004612          MSL2:  NM_001145417     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-186-3p	MSL2
miRBase Accession/Entrez ID	MIMAT0004612	55167
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	MSL-2//MSL2L1//RNF184

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-186-3p	rs1241044041 chr1:71067653    C/T rs1318830037 chr1:71067663    C/A rs1318830037 chr1:71067663    C/T rs771255877 chr1:71067645    A/C rs776722712 chr1:71067655    C/T rs934513177 chr1:71067651    T/C rs1292420312 chr1:71067659    T/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MSL2	chr3:135910507(-) A-I      intronic chr3:135898229(-) A-I      intronic chr3:135898220(-) A-I      intronic chr3:135898207(-) A-I      intronic chr3:135898199(-) A-I      intronic chr3:135898204(-) A-I      intronic chr3:135907164(-) A-I      intronic chr3:135907163(-) A-I      intronic chr3:135904530(-) A-I      intronic chr3:135904526(-) A-I      intronic chr3:135904525(-) A-I      intronic chr3:135903993(-) A-I      intronic chr3:135903419(-) A-I      intronic chr3:135903406(-) A-I      intronic chr3:135903026(-) A-I      intronic chr3:135882062(-) A-I      intronic chr3:135882032(-) A-I      intronic chr3:135882017(-) A-I      intronic chr3:135882015(-) A-I      intronic chr3:135881982(-) A-I      intronic chr3:135880957(-) A-I      intronic chr3:135880956(-) A-I      intronic chr3:135880949(-) A-I      intronic chr3:135880842(-) A-I      intronic chr3:135878942(-) A-I      intronic chr3:135878931(-) A-I      intronic chr3:135878929(-) A-I      intronic chr3:135878922(-) A-I      intronic chr3:135876300(-) A-I      intronic chr3:135876287(-) A-I      intronic chr3:135898243(-) A-I      intronic chr3:135898267(-) A-I      intronic chr3:135898271(-) A-I      intronic chr3:135898652(-) A-I      intronic chr3:135898691(-) A-I      intronic chr3:135911145(-) A-I      intronic chr3:135898704(-) A-I      intronic chr3:135898710(-) A-I      intronic chr3:135899359(-) A-I      intronic chr3:135899479(-) A-I      intronic chr3:135899480(-) A-I      intronic chr3:135899482(-) A-I      intronic chr3:135902155(-) A-I      intronic chr3:135902237(-) A-I      intronic chr3:135902893(-) A-I      intronic chr3:135902894(-) A-I      intronic chr3:135907193(-) A-I      intronic chr3:135907194(-) A-I      intronic chr3:135910143(-) A-I      intronic chr3:135910198(-) A-I      intronic chr3:135910426(-) A-I      intronic chr3:135911215(-) A-I      intronic chr3:135911277(-) A-I      intronic chr3:135876269(-) A-I      intronic chr3:135876164(-) A-I      intronic chr3:135871960(-) A-I      intronic chr3:135888485(-) A-I      intronic chr3:135888532(-) A-I      intronic chr3:135888774(-) A-I      intronic chr3:135888785(-) A-I      intronic chr3:135888786(-) A-I      intronic chr3:135889112(-) A-I      intronic chr3:135889456(-) A-I      intronic chr3:135889479(-) A-I      intronic chr3:135888967(-) A-I      intronic chr3:135889489(-) A-I      intronic chr3:135890926(-) A-I      intronic chr3:135891870(-) A-I      intronic chr3:135891875(-) A-I      intronic chr3:135891943(-) A-I      intronic chr3:135897440(-) A-I      intronic chr3:135897545(-) A-I      intronic chr3:135898039(-) A-I      intronic chr3:135888402(-) A-I      intronic chr3:135888399(-) A-I      intronic chr3:135888348(-) A-I      intronic chr3:135885173(-) A-I      intronic chr3:135885143(-) A-I      intronic chr3:135883969(-) A-I      intronic chr3:135883803(-) A-I      intronic chr3:135883755(-) A-I      intronic chr3:135884983(-) A-I      intronic chr3:135904026(-) A-I      intronic chr3:135911293(-) A-I      intronic chr3:135898252(-) A-I      intronic chr3:135889067(-) A-I      intronic chr3:135911185(-) A-I      intronic chr3:135882018(-) A-I      intronic chr3:135888471(-) A-I      intronic chr3:135883936(-) A-I      intronic chr3:135881979(-) A-I      intronic chr3:135911031(-) A-I      intronic chr3:135889519(-) A-I      intronic chr3:135898275(-) A-I      intronic chr3:135903051(-) A-I      intronic chr3:135908417(-) A-I      intronic chr3:135889571(-) A-I      intronic chr3:135883860(-) A-I      intronic chr3:135878857(-) A-I      intronic chr3:135903350(-) A-I      intronic chr3:135879074(-) A-I      intronic chr3:135885148(-) A-I      intronic chr3:135891942(-) A-I      intronic chr3:135890845(-) A-I      intronic chr3:135904077(-) A-I      intronic chr3:135902895(-) A-I      intronic chr3:135883788(-) A-I      intronic chr3:135903186(-) A-I      intronic chr3:135883783(-) A-I      intronic chr3:135889095(-) A-I      intronic chr3:135902372(-) A-I      intronic chr3:135881276(-) A-I      intronic chr3:135881989(-) A-I      intronic chr3:135898705(-) A-I      intronic chr3:135897472(-) A-I      intronic chr3:135896327(-) A-I      intronic chr3:135908322(-) A-I      intronic chr3:135880877(-) A-I      intronic chr3:135908828(-) A-I      intronic chr3:135888940(-) A-I      intronic chr3:135911158(-) A-I      intronic chr3:135881168(-) A-I      intronic chr3:135890811(-) A-I      intronic chr3:135911087(-) A-I      intronic chr3:135910553(-) A-I      intronic chr3:135899895(-) A-I      intronic chr3:135885013(-) A-I      intronic chr3:135899980(-) A-I      intronic chr3:135883837(-) A-I      intronic chr3:135910499(-) A-I      intronic chr3:135888495(-) A-I      intronic chr3:135903323(-) A-I      intronic chr3:135897669(-) A-I      intronic chr3:135888770(-) A-I      intronic chr3:135890904(-) A-I      intronic chr3:135883778(-) A-I      intronic chr3:135888356(-) A-I      intronic chr3:135885081(-) A-I      intronic chr3:135888758(-) A-I      intronic chr3:135907084(-) A-I      intronic chr3:135879006(-) A-I      intronic chr3:135898125(-) A-I      intronic chr3:135890816(-) A-I      intronic chr3:135885082(-) A-I      intronic chr3:135889073(-) A-I      intronic chr3:135910411(-) A-I      intronic chr3:135888333(-) A-I      intronic chr3:135897471(-) A-I      intronic chr3:135910187(-) A-I      intronic chr3:135882049(-) A-I      intronic chr3:135908917(-) A-I      intronic chr3:135906443(-) A-I      intronic chr3:135890825(-) A-I      intronic chr3:135878278(-) A-I      intronic chr3:135904446(-) A-I      intronic chr3:135903200(-) A-I      intronic chr3:135899962(-) A-I      intronic chr3:135883821(-) A-I      intronic chr3:135910117(-) A-I      intronic chr3:135889518(-) A-I      intronic chr3:135899797(-) A-I      intronic chr3:135872024(-) A-I      intronic chr3:135889422(-) A-I      intronic chr3:135891998(-) A-I      intronic chr3:135903954(-) A-I      intronic chr3:135883910(-) A-I      intronic chr3:135903107(-) A-I      intronic chr3:135879031(-) A-I      intronic chr3:135890858(-) A-I      intronic chr3:135904471(-) A-I      intronic chr3:135911100(-) A-I      intronic chr3:135889154(-) A-I      intronic chr3:135898808(-) A-I      intronic chr3:135883848(-) A-I      intronic chr3:135902429(-) A-I      intronic chr3:135876342(-) A-I      intronic chr3:135910253(-) A-I      intronic chr3:135878996(-) A-I      intronic chr3:135910430(-) A-I      intronic chr3:135880945(-) A-I      intronic chr3:135903094(-) A-I      intronic chr3:135888496(-) A-I      intronic chr3:135898314(-) A-I      intronic chr3:135881341(-) A-I      intronic chr3:135888776(-) A-I      intronic chr3:135888736(-) A-I      intronic chr3:135898824(-) A-I      intronic chr3:135885026(-) A-I      intronic chr3:135889083(-) A-I      intronic chr3:135899379(-) A-I      intronic chr3:135888387(-) A-I      intronic chr3:135881256(-) A-I      intronic chr3:135911159(-) A-I      intronic chr3:135903955(-) A-I      intronic chr3:135910365(-) A-I      intronic chr3:135888939(-) A-I      intronic chr3:135889071(-) A-I      intronic chr3:135882001(-) A-I      intronic chr3:135910493(-) A-I      intronic chr3:135877032(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MSL2	chr3:135899980(-) A-I intron -    21960545 chr3:135868443(-) C-T exon 3'UTR    21725310 chr3:135877032(-) A-G intron -    22484847 chr3:135880981(-) A-G intron -    22484847 chr3:135880983(-) A-G intron -    22484847 chr3:135882049(-) A-G intron -    22484847 chr3:135885013(-) A-G intron -    22484847 chr3:135885082(-) A-G intron -    22484847 chr3:135888333(-) A-G intron -    22484847 chr3:135888356(-) A-G intron -    22484847 chr3:135888387(-) A-G intron -    22484847 chr3:135888388(-) A-G intron -    22484847 chr3:135888471(-) A-G intron -    22484847 chr3:135888495(-) A-G intron -    22484847 chr3:135888496(-) A-G intron -    22484847 chr3:135888541(-) A-G intron -    22484847 chr3:135888669(-) A-G intron -    22484847 chr3:135888736(-) A-G intron -    22484847 chr3:135888758(-) A-G intron -    22484847 chr3:135888770(-) A-G intron -    22484847 chr3:135888776(-) A-G intron -    22484847 chr3:135888939(-) A-G intron -    22484847 chr3:135888940(-) A-G intron -    22484847 chr3:135888949(-) A-G intron -    22484847 chr3:135889067(-) A-G intron -    22484847 chr3:135889071(-) A-G intron -    22484847 chr3:135889073(-) A-G intron -    22484847 chr3:135889083(-) A-G intron -    22484847 chr3:135889095(-) A-G intron -    22484847 chr3:135889111(-) A-G intron -    22484847 chr3:135889154(-) A-G intron -    22484847 chr3:135889507(-) A-G intron -    22484847 chr3:135889518(-) A-G intron -    22484847 chr3:135889519(-) A-G intron -    22484847 chr3:135889573(-) A-G intron -    22484847 chr3:135890811(-) A-G intron -    22484847 chr3:135890845(-) A-G intron -    22484847 chr3:135891942(-) A-G intron -    22484847 chr3:135896327(-) A-G intron -    22484847 chr3:135898115(-) T-C intron -    22484847 chr3:135898125(-) A-G intron -    22484847 chr3:135898314(-) A-G intron -    22484847 chr3:135898705(-) A-G intron -    22484847 chr3:135898808(-) A-G intron -    22484847 chr3:135899849(-) T-A intron -    22484847 chr3:135899851(-) G-T intron -    22484847 chr3:135899895(-) A-G intron -    22484847 chr3:135899962(-) A-G intron -    22484847 chr3:135899980(-) A-G intron -    22484847 chr3:135902458(-) A-C intron -    22484847 chr3:135903038(-) A-G intron -    22484847 chr3:135903051(-) A-G intron -    22484847 chr3:135903186(-) A-G intron -    22484847 chr3:135903200(-) A-G intron -    22484847 chr3:135903954(-) A-G intron -    22484847 chr3:135903997(-) A-G intron -    22484847 chr3:135904026(-) A-G intron -    22484847 chr3:135904077(-) A-G intron -    22484847 chr3:135908322(-) A-G intron -    22484847 chr3:135910117(-) A-G intron -    22484847 chr3:135910187(-) A-G intron -    22484847 chr3:135910253(-) A-G intron -    22484847 chr3:135910430(-) A-G intron -    22484847 chr3:135910493(-) A-G intron -    22484847 chr3:135910499(-) A-G intron -    22484847 chr3:135910553(-) A-G intron -    22484847 chr3:135910558(-) A-G intron -    22484847 chr3:135911158(-) A-G intron -    22484847 chr3:135911159(-) A-G intron -    22484847 chr3:135911185(-) A-G intron -    22484847 chr3:135911224(-) A-G intron -    22484847 chr3:135911293(-) A-G intron -    22484847 chr3:135911294(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MSL2	chr3:135868324-135868325(-) m6A 3'UTR       27773535 chr3:135868518-135868519(-) Y 3'UTR       26075521 chr3:135868550-135868551(-) m6A 3'UTR       24209618//24981863 chr3:135868558-135868559(-) m6A 3'UTR       24209618//24981863 chr3:135868571-135868572(-) m6A 3'UTR       24209618//24981863 chr3:135868770-135868771(-) m6A 3'UTR       24981863//26404942 chr3:135868776-135868777(-) m6A 3'UTR       24981863//26404942 chr3:135868832-135868833(-) m6A 3'UTR       24981863 chr3:135869726-135869727(-) m6A 3'UTR       26404942 chr3:135869759-135869760(-) m6A 3'UTR       26404942 chr3:135869775-135869776(-) m6A 3'UTR       26404942 chr3:135869970-135869971(-) m6A 3'UTR       - chr3:135870007-135870008(-) m6A CDS       22608085 chr3:135870155-135870156(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22575960//22608085 chr3:135870223-135870224(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085 chr3:135870357-135870358(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr3:135870371-135870372(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr3:135870430-135870431(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085 chr3:135870455-135870456(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085 chr3:135870483-135870484(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085 chr3:135870524-135870525(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085 chr3:135870819-135870820(-) m6A CDS       24284625//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr3:135870844-135870845(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr3:135870887-135870888(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr3:135870931-135870932(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr3:135870939-135870940(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr3:135871040-135871041(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr3:135871083-135871084(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr3:135871227-135871228(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr3:135871287-135871288(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr3:135871295-135871296(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr3:135871385-135871386(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085 chr3:135871407-135871408(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085 chr3:135871420-135871421(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085 chr3:135871444-135871445(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr3:135871465-135871466(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr3:135871488-135871489(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22575960//22608085 chr3:135871517-135871518(-) m6A 5'UTR//CDS       24284625//24209618//24981863//27773535//27371828//22575960//22608085 chr3:135913329-135913330(-) m6A 5'UTR//intron       24284625//27773535 chr3:135913341-135913342(-) m6A 5'UTR//intron       24284625//27773535 chr3:135913356-135913357(-) m6A 5'UTR//intron       24284625 chr3:135913393-135913394(-) m6A 5'UTR//intron       24284625 chr3:135913884-135913885(-) m6A CDS//intron       24284625//24209618//27773535//22608085 chr3:135913950-135913951(-) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085 chr3:135914105-135914106(-) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr3:135914205-135914206(-) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr3:135914274-135914275(-) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr3:135914624-135914625(-) m6A 5'UTR//intron       24284625//27371828//27773536 chr3:135914652-135914653(-) m6A 5'UTR//intron       24284625//27371828//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-186-3p	Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Mesenchymal stem cells     -
	MSL2	Chromatin HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-186-3p
Interactor2: MSL2

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.