Detail Information

Basic Information:


  VIRBase ID:  

HHID00066008

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-186-3p:           IFI30:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-186-3p IFI30
miRBase
Accession/Entrez ID		 MIMAT0004612 10437
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - GILT//IFI-30//IP-30//IP30

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-186-3p
rs1241044041 chr1:71067653    C/T
rs1318830037 chr1:71067663    C/A
rs1318830037 chr1:71067663    C/T
rs771255877 chr1:71067645    A/C
rs776722712 chr1:71067655    C/T
rs934513177 chr1:71067651    T/C
rs1292420312 chr1:71067659    T/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR IFI30
chr19:18285435(+) A-I      intronic
chr19:18287082(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED IFI30
chr19:18288551(+) A-I exon CDS    19478186
chr19:18287082(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase IFI30
chr19:18284580-18284581(+) m6A 5'UTR//intron       24284625//24981863
chr19:18284748-18284749(+) m6A CDS       24284625//25456834//24981863//22575960
chr19:18285882-18285883(+) m1A CDS//exon       26863196//26863410
chr19:18286122-18286123(+) m6A CDS//exon       22575960
chr19:18286431-18286432(+) m6A CDS//exon       22575960
chr19:18286484-18286485(+) m6A CDS//exon       22575960
chr19:18287983-18287984(+) m6A CDS//exon       22575960
chr19:18288010-18288011(+) m6A CDS//exon       22575960
chr19:18288762-18288763(+) m6A 3'UTR//exon       22575960
chr19:18288793-18288794(+) m6A 3'UTR//exon       27773535//22575960
chr19:18288912-18288913(+) m6A 3'UTR//exon       24284625//24981863//27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-186-3p
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Mesenchymal stem cells     -
IFI30
Cytosol K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-186-3p
Interactor2: IFI30

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region CDS
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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