Basic Information:

  VIRBase ID:  

HHID00066005

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-186-3p:  MIMAT0004612          PTK2B:  NM_173176     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-186-3p	PTK2B
miRBase Accession/Entrez ID	MIMAT0004612	2185
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CADTK//CAKB//FADK2//FAK2//PKB//PTK//PYK2//RAFTK

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-186-3p	rs1241044041 chr1:71067653    C/T rs1318830037 chr1:71067663    C/A rs1318830037 chr1:71067663    C/T rs771255877 chr1:71067645    A/C rs776722712 chr1:71067655    C/T rs934513177 chr1:71067651    T/C rs1292420312 chr1:71067659    T/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PTK2B	chr8:27259296(+) A-I      intronic chr8:27259280(+) A-I      intronic chr8:27194792(+) A-I      intronic chr8:27194818(+) A-I      intronic chr8:27194863(+) A-I      intronic chr8:27194882(+) A-I      intronic chr8:27194896(+) A-I      intronic chr8:27199247(+) A-I      intronic chr8:27199266(+) A-I      intronic chr8:27199290(+) A-I      intronic chr8:27199428(+) A-I      intronic chr8:27199852(+) A-I      intronic chr8:27199904(+) A-I      intronic chr8:27202455(+) A-I      intronic chr8:27202502(+) A-I      intronic chr8:27202553(+) A-I      intronic chr8:27202559(+) A-I      intronic chr8:27202560(+) A-I      intronic chr8:27202569(+) A-I      intronic chr8:27202605(+) A-I      intronic chr8:27202613(+) A-I      intronic chr8:27202629(+) A-I      intronic chr8:27226972(+) A-I      intronic chr8:27227008(+) A-I      intronic chr8:27189130(+) A-I      intronic chr8:27189145(+) A-I      intronic chr8:27189149(+) A-I      intronic chr8:27227029(+) A-I      intronic chr8:27189206(+) A-I      intronic chr8:27243226(+) A-I      intronic chr8:27189209(+) A-I      intronic chr8:27189266(+) A-I      intronic chr8:27189278(+) A-I      intronic chr8:27192885(+) A-I      intronic chr8:27192896(+) A-I      intronic chr8:27193015(+) A-I      intronic chr8:27194358(+) A-I      intronic chr8:27194452(+) A-I      intronic chr8:27194453(+) A-I      intronic chr8:27194752(+) A-I      intronic chr8:27202530(+) A-I      intronic chr8:27202529(+) A-I      intronic chr8:27202479(+) A-I      intronic chr8:27192939(+) A-I      intronic chr8:27192924(+) A-I      intronic chr8:27192890(+) A-I      intronic chr8:27171924(+) A-I      intronic chr8:27176342(+) A-I      intronic chr8:27176348(+) A-I      intronic chr8:27176365(+) A-I      intronic chr8:27176420(+) A-I      intronic chr8:27176429(+) A-I      intronic chr8:27176430(+) A-I      intronic chr8:27177040(+) A-I      intronic chr8:27177046(+) A-I      intronic chr8:27177081(+) A-I      intronic chr8:27267516(+) A-I      intronic chr8:27267308(+) A-I      intronic chr8:27267288(+) A-I      intronic chr8:27258583(+) A-I      intronic chr8:27178581(+) A-I      intronic chr8:27258549(+) A-I      intronic chr8:27258486(+) A-I      intronic chr8:27248750(+) A-I      intronic chr8:27248714(+) A-I      intronic chr8:27248654(+) A-I      intronic chr8:27243359(+) A-I      intronic chr8:27243290(+) A-I      intronic chr8:27243289(+) A-I      intronic chr8:27243190(+) A-I      intronic chr8:27241272(+) A-I      intronic chr8:27240862(+) A-I      intronic chr8:27194782(+) A-I      intronic chr8:27228664(+) A-I      intronic chr8:27227352(+) A-I      intronic chr8:27227351(+) A-I      intronic chr8:27227044(+) A-I      intronic chr8:27227037(+) A-I      intronic chr8:27194770(+) A-I      intronic chr8:27227036(+) A-I      intronic chr8:27227031(+) A-I      intronic chr8:27241775(+) A-I      intronic chr8:27189104(+) A-I      intronic chr8:27248834(+) A-I      intronic chr8:27190225(+) A-I      intronic chr8:27248802(+) A-I      intronic chr8:27194837(+) A-I      intronic chr8:27199293(+) A-I      intronic chr8:27228539(+) A-I      intronic chr8:27203868(+) A-I      intronic chr8:27194868(+) A-I      intronic chr8:27194888(+) A-I      intronic chr8:27203983(+) A-I      intronic chr8:27311261(+) A-I      intronic chr8:27202573(+) A-I      intronic chr8:27241714(+) A-I      intronic chr8:27202527(+) A-I      intronic chr8:27176415(+) A-I      intronic chr8:27203838(+) A-I      intronic chr8:27193058(+) A-I      intronic chr8:27194918(+) A-I      intronic chr8:27192923(+) A-I      intronic chr8:27189133(+) A-I      intronic chr8:27190203(+) A-I      intronic chr8:27177089(+) A-I      intronic chr8:27192920(+) A-I      intronic chr8:27228593(+) A-I      intronic chr8:27248037(+) A-I      intronic chr8:27190199(+) A-I      intronic chr8:27186705(+) A-I      intronic chr8:27202469(+) A-I      intronic chr8:27199244(+) A-I      intronic chr8:27203798(+) A-I      intronic chr8:27199249(+) A-I      intronic chr8:27192945(+) A-I      intronic chr8:27248743(+) A-I      intronic chr8:27199336(+) A-I      intronic chr8:27190125(+) A-I      intronic chr8:27202533(+) A-I      intronic chr8:27199357(+) A-I      intronic chr8:27194834(+) A-I      intronic chr8:27172404(+) A-I      intronic chr8:27194427(+) A-I      intronic chr8:27241459(+) A-I      intronic chr8:27248031(+) A-I      intronic chr8:27227314(+) A-I      intronic chr8:27202503(+) A-I      intronic chr8:27228538(+) A-I      intronic chr8:27227414(+) A-I      intronic chr8:27199905(+) A-I      intronic chr8:27192988(+) A-I      intronic chr8:27199835(+) A-I      intronic chr8:27176204(+) A-I      intronic chr8:27248849(+) A-I      intronic chr8:27247970(+) A-I      intronic chr8:27201270(+) A-I      intronic chr8:27199317(+) A-I      intronic chr8:27218835(+) A-I      intronic chr8:27240863(+) A-I      intronic chr8:27176268(+) A-I      intronic chr8:27248731(+) A-I      intronic chr8:27179600(+) A-I      intronic chr8:27201475(+) A-I      intronic chr8:27239518(+) A-I      intronic chr8:27171845(+) A-I      intronic chr8:27176974(+) A-I      intronic chr8:27312811(+) A-I      intronic chr8:27243287(+) A-I      intronic chr8:27194417(+) A-I      intronic chr8:27190299(+) A-I      intronic chr8:27186727(+) A-I      intronic chr8:27227373(+) A-I      intronic chr8:27192914(+) A-I      intronic chr8:27199320(+) A-I      intronic chr8:27202624(+) A-I      intronic chr8:27189143(+) A-I      intronic chr8:27176982(+) A-I      intronic chr8:27178612(+) A-I      intronic chr8:27290444(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PTK2B	chr8:27259349(+) A-I intron -    22327324 chr8:27259260(+) A-G intron -    22484847 chr8:27259287(+) A-G intron -    22484847 chr8:27259349(+) A-G intron -    22484847 chr8:27171845(+) A-G intron -    22484847 chr8:27176415(+) A-G intron -    22484847 chr8:27176926(+) A-G intron -    22484847 chr8:27178612(+) A-G intron -    22484847 chr8:27179600(+) A-G intron -    22484847 chr8:27186705(+) A-G intron -    22484847 chr8:27189104(+) A-G intron -    22484847 chr8:27189133(+) A-G intron -    22484847 chr8:27189143(+) A-G intron -    22484847 chr8:27190125(+) A-G intron -    22484847 chr8:27190199(+) A-G intron -    22484847 chr8:27190202(+) A-G intron -    22484847 chr8:27190203(+) A-G intron -    22484847 chr8:27192833(+) A-G intron -    22484847 chr8:27192863(+) A-G intron -    22484847 chr8:27192914(+) A-G intron -    22484847 chr8:27192920(+) A-G intron -    22484847 chr8:27192923(+) A-G intron -    22484847 chr8:27192945(+) A-G intron -    22484847 chr8:27192998(+) A-G intron -    22484847 chr8:27193006(+) A-G intron -    22484847 chr8:27193058(+) A-G intron -    22484847 chr8:27193132(+) G-A intron -    22484847 chr8:27194416(+) A-G intron -    22484847 chr8:27194417(+) A-G intron -    22484847 chr8:27194427(+) A-G intron -    22484847 chr8:27194753(+) A-G intron -    22484847 chr8:27194834(+) A-G intron -    22484847 chr8:27194837(+) A-G intron -    22484847 chr8:27194868(+) A-G intron -    22484847 chr8:27194888(+) A-G intron -    22484847 chr8:27194914(+) A-G intron -    22484847 chr8:27194918(+) A-G intron -    22484847 chr8:27199249(+) A-G intron -    22484847 chr8:27199284(+) A-G intron -    22484847 chr8:27199308(+) A-G intron -    22484847 chr8:27199317(+) A-G intron -    22484847 chr8:27199320(+) A-G intron -    22484847 chr8:27199330(+) A-G intron -    22484847 chr8:27199332(+) A-G intron -    22484847 chr8:27199336(+) A-G intron -    22484847 chr8:27199355(+) T-C intron -    22484847 chr8:27199357(+) A-G intron -    22484847 chr8:27199827(+) A-G intron -    22484847 chr8:27199835(+) A-G intron -    22484847 chr8:27201270(+) A-G intron -    22484847 chr8:27201275(+) T-G intron -    22484847 chr8:27201380(+) T-C intron -    22484847 chr8:27201475(+) A-G intron -    22484847 chr8:27202444(+) C-T intron -    22484847 chr8:27202503(+) A-G intron -    22484847 chr8:27202527(+) A-G intron -    22484847 chr8:27202533(+) A-G intron -    22484847 chr8:27202573(+) A-G intron -    22484847 chr8:27202624(+) A-G intron -    22484847 chr8:27203786(+) G-T intron -    22484847 chr8:27203838(+) A-G intron -    22484847 chr8:27203909(+) G-A intron -    22484847 chr8:27203983(+) A-G intron -    22484847 chr8:27213285(+) A-G intron -    22484847 chr8:27213396(+) T-C intron -    22484847 chr8:27227007(+) T-C intron -    22484847 chr8:27227223(+) A-G intron -    22484847 chr8:27227263(+) A-G intron -    22484847 chr8:27227314(+) A-G intron -    22484847 chr8:27227321(+) C-G intron -    22484847 chr8:27227373(+) A-G intron -    22484847 chr8:27227414(+) A-G intron -    22484847 chr8:27228538(+) A-G intron -    22484847 chr8:27228539(+) A-G intron -    22484847 chr8:27228593(+) A-G intron -    22484847 chr8:27228647(+) A-G intron -    22484847 chr8:27229169(+) A-G intron -    22484847 chr8:27231078(+) A-G intron -    22484847 chr8:27231095(+) G-A intron -    22484847 chr8:27239518(+) A-G intron -    22484847 chr8:27240863(+) A-G intron -    22484847 chr8:27240946(+) A-G intron -    22484847 chr8:27241459(+) A-G intron -    22484847 chr8:27241745(+) T-C intron -    22484847 chr8:27248743(+) A-G intron -    22484847 chr8:27248834(+) A-G intron -    22484847 chr8:27248849(+) A-G intron -    22484847 chr8:27290444(+) A-G intron -    22484847 chr8:27292244(+) T-G intron -    22484847 chr8:27302675(+) T-C intron -    22484847 chr8:27302785(+) G-C intron -    22484847 chr8:27305130(+) T-C intron -    22484847 chr8:27305141(+) C-T intron -    22484847 chr8:27305146(+) T-C intron -    22484847 chr8:27305150(+) T-A intron -    22484847 chr8:27309985(+) C-T intron -    22484847 chr8:27310095(+) G-A intron -    22484847 chr8:27310098(+) C-A intron -    22484847 chr8:27311261(+) A-G intron -    22484847 chr8:27261738(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PTK2B	chr8:27297906-27297907(+) m6A CDS       - chr8:27300414-27300415(+) m6A CDS       - chr8:27300452-27300453(+) m6A CDS       24981863 chr8:27300487-27300488(+) m6A CDS       24981863 chr8:27301742-27301743(+) m6A CDS       24981863 chr8:27301755-27301756(+) m6A CDS       24981863 chr8:27308272-27308273(+) m6A CDS       24981863 chr8:27308350-27308351(+) m6A CDS       24981863 chr8:27308377-27308378(+) m6A CDS       24981863 chr8:27312122-27312123(+) m6A CDS//exon       - chr8:27315827-27315828(+) m6A CDS//exon       - chr8:27315841-27315842(+) m6A CDS//exon       - chr8:27315961-27315962(+) m6A CDS//exon       24284625 chr8:27315979-27315980(+) m6A CDS//exon       - chr8:27316208-27316209(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr8:27316217-27316218(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr8:27316231-27316232(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr8:27316268-27316269(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr8:27316369-27316370(+) m6A 3'UTR       25456834//24981863 chr8:27316390-27316391(+) m6A 3'UTR       25456834//24981863 chr8:27316558-27316559(+) m6A 3'UTR       - chr8:27316587-27316588(+) m6A 3'UTR       - chr8:27316607-27316608(+) m6A 3'UTR       - chr8:27316653-27316654(+) m6A 3'UTR       - chr8:27316698-27316699(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-186-3p	Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Mesenchymal stem cells     -
	PTK2B	Chromatin K562 cells     - Cytosol K562 cells     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-186-3p
Interactor2: PTK2B

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.