Basic Information:

  VIRBase ID:  

HHID00066003

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-186-3p:  MIMAT0004612          CRY2:  NM_021117     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-186-3p	CRY2
miRBase Accession/Entrez ID	MIMAT0004612	1408
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HCRY2//PHLL2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-186-3p	rs1241044041 chr1:71067653    C/T rs1318830037 chr1:71067663    C/A rs1318830037 chr1:71067663    C/T rs771255877 chr1:71067645    A/C rs776722712 chr1:71067655    C/T rs934513177 chr1:71067651    T/C rs1292420312 chr1:71067659    T/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CRY2	chr11:45885919(+) A-I      intronic chr11:45886243(+) A-I      intronic chr11:45885912(+) A-I      intronic chr11:45886491(+) A-I      intronic chr11:45886494(+) A-I      intronic chr11:45888371(+) A-I      intronic chr11:45885996(+) A-I      intronic chr11:45885927(+) A-I      intronic chr11:45886237(+) A-I      intronic chr11:45886452(+) A-I      intronic chr11:45886573(+) A-I      intronic chr11:45886233(+) A-I      intronic chr11:45885988(+) A-I      intronic chr11:45885918(+) A-I      intronic chr11:45883232(+) A-I      intronic chr11:45886289(+) A-I      intronic chr11:45888246(+) A-I      intronic chr11:45886450(+) A-I      intronic chr11:45885972(+) A-I      intronic chr11:45886591(+) A-I      intronic chr11:45886508(+) A-I      intronic chr11:45886205(+) A-I      intronic chr11:45886531(+) A-I      intronic chr11:45871685(+) A-I      intronic chr11:45880959(+) A-I      intronic chr11:45886169(+) A-I      intronic chr11:45888254(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CRY2	chr11:45898559(+) A-I intron -    21960545

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CRY2	chr11:45869035-45869036(+) m6A 5'UTR//CDS//exon//intron       24981863 chr11:45869099-45869100(+) m6A CDS//exon//intron       24981863 chr11:45883577-45883578(+) m6A exon//intron       - chr11:45883626-45883627(+) m6A CDS//exon//intron       - chr11:45883657-45883658(+) m6A CDS//exon//intron       - chr11:45888982-45888983(+) m6A exon//intron       - chr11:45889027-45889028(+) m6A exon//intron       - chr11:45893703-45893704(+) m6A CDS//exon       - chr11:45893718-45893719(+) m6A CDS//exon       - chr11:45904295-45904296(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-186-3p	Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Mesenchymal stem cells     -
	CRY2	Chromatin K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-186-3p
Interactor2: CRY2

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.