Basic Information:

  VIRBase ID:  

HHID00065649

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-let-7g-3p:  MIMAT0004584          ZCCHC2:  NM_017742     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-let-7g-3p	ZCCHC2
miRBase Accession/Entrez ID	MIMAT0004584	54877
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	C18orf49

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-let-7g-3p	rs1022640944 chr3:52268290    G/A rs1166657040 chr3:52268299    A/G rs1356748432 chr3:52268293    C/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZCCHC2	chr18:60214280(+) A-I      intronic chr18:60214894(+) A-I      intronic chr18:60214302(+) A-I      intronic chr18:60214372(+) A-I      intronic chr18:60214995(+) A-I      intronic chr18:60214934(+) A-I      intronic chr18:60214921(+) A-I      intronic chr18:60215004(+) A-I      intronic chr18:60214382(+) A-I      intronic chr18:60214393(+) A-I      intronic chr18:60215033(+) A-I      intronic chr18:60229426(+) A-I      intronic chr18:60214473(+) A-I      intronic chr18:60214548(+) A-I      intronic chr18:60222801(+) A-I      intronic chr18:60220033(+) A-I      intronic chr18:60229356(+) A-I      intronic chr18:60200837(+) A-I      intronic chr18:60214416(+) A-I      intronic chr18:60204627(+) A-I      intronic chr18:60216197(+) A-I      intronic chr18:60204511(+) A-I      intronic chr18:60201025(+) A-I      intronic chr18:60201454(+) A-I      intronic chr18:60214895(+) A-I      intronic chr18:60204461(+) A-I      intronic chr18:60204651(+) A-I      intronic chr18:60204538(+) A-I      intronic chr18:60215016(+) A-I      intronic chr18:60215965(+) A-I      intronic chr18:60214912(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ZCCHC2	chr18:60244998(+) A-I intron -    21960545 chr18:60209797(+) A-C exon CDS    21725310

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZCCHC2	chr18:60190300-60190301(+) m6A 5'UTR       25456834//24981863 chr18:60190362-60190363(+) m6A 5'UTR       24284625//25456834//24981863 chr18:60190405-60190406(+) m6A 5'UTR       24284625//25456834//24981863 chr18:60190516-60190517(+) m6A 5'UTR       24209618 chr18:60190854-60190855(+) m6A CDS       - chr18:60191015-60191016(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr18:60191063-60191064(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr18:60191078-60191079(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr18:60191126-60191127(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr18:60191207-60191208(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr18:60191252-60191253(+) m6A CDS       24209618//25456834//24981863//22575960//22608085 chr18:60191430-60191431(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr18:60191502-60191503(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr18:60191620-60191621(+) m6A CDS//intron       24284625//25456834//24981863//22575960//22608085 chr18:60191805-60191806(+) m6A CDS//intron       24284625//24209618 chr18:60191976-60191977(+) m6A CDS//intron       25456834 chr18:60192136-60192137(+) m6A 3'UTR//intron       24209618 chr18:60192222-60192223(+) m6A 3'UTR//intron       24284625//24209618 chr18:60192237-60192238(+) m6A 3'UTR//intron       24284625//24209618 chr18:60241363-60241364(+) m6A CDS//exon       22608085 chr18:60241418-60241419(+) m6A CDS//exon       22608085 chr18:60241439-60241440(+) m6A CDS//exon       22608085 chr18:60241536-60241537(+) m6A CDS//exon       22608085 chr18:60241552-60241553(+) m6A CDS//exon       22608085 chr18:60241847-60241848(+) m6A CDS//exon       24284625//24209618//24981863//22608085 chr18:60241910-60241911(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr18:60241944-60241945(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr18:60241976-60241977(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr18:60241984-60241985(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr18:60242108-60242109(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr18:60242294-60242295(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr18:60242311-60242312(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr18:60242380-60242381(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr18:60242390-60242391(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr18:60242433-60242434(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr18:60242519-60242520(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr18:60242545-60242546(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr18:60242562-60242563(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr18:60242733-60242734(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr18:60242747-60242748(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr18:60243754-60243755(+) m6A CDS//exon       24284625//25456834//24981863//22575960//22608085 chr18:60243807-60243808(+) m6A CDS//exon       24284625//25456834//24981863//22575960//22608085 chr18:60244496-60244497(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr18:60244506-60244507(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr18:60244533-60244534(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr18:60244552-60244553(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr18:60244601-60244602(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr18:60244612-60244613(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr18:60244708-60244709(+) m6A 3'UTR//intron       24284625 chr18:60245376-60245377(+) m6A 3'UTR//intron       24981863 chr18:60252239-60252240(+) m6A 3'UTR//exon//intron       - chr18:60252254-60252255(+) m6A 3'UTR//exon//intron       - chr18:60252277-60252278(+) m6A 3'UTR//exon//intron       - chr18:60252377-60252378(+) m6A 3'UTR//exon//intron       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-let-7g-3p	Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Serum     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cerebrospinal fluid     24797360 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -
	ZCCHC2	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane HCC cell line (HepG2)     - Nucleus HCC cell line (HepG2)|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-let-7g-3p
Interactor2: ZCCHC2

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.