Basic Information:

  VIRBase ID:  

HHID00065645

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-let-7g-3p:  MIMAT0004584          ZNF451:  NM_001031623     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-let-7g-3p	ZNF451
miRBase Accession/Entrez ID	MIMAT0004584	26036
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	COASTER//dJ417I1.1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-let-7g-3p	rs1022640944 chr3:52268290    G/A rs1166657040 chr3:52268299    A/G rs1356748432 chr3:52268293    C/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZNF451	chr6:56981282(+) A-I      intronic chr6:57003664(+) A-I      intronic chr6:56983384(+) A-I      intronic chr6:56983442(+) A-I      intronic chr6:56983465(+) A-I      intronic chr6:56983472(+) A-I      intronic chr6:56984092(+) A-I      intronic chr6:56998631(+) A-I      intronic chr6:57025271(+) A-I      intronic chr6:57025212(+) A-I      intronic chr6:56983448(+) A-I      intronic chr6:56983428(+) A-I      intronic chr6:56963005(+) A-I      intronic chr6:56963026(+) A-I      intronic chr6:56963029(+) A-I      intronic chr6:56979803(+) A-I      intronic chr6:56979811(+) A-I      intronic chr6:56979825(+) A-I      intronic chr6:56979901(+) A-I      intronic chr6:56979929(+) A-I      intronic chr6:56979937(+) A-I      intronic chr6:56980047(+) A-I      intronic chr6:56980044(+) A-I      intronic chr6:56980043(+) A-I      intronic chr6:56980019(+) A-I      intronic chr6:57009139(+) A-I      intronic chr6:56979947(+) A-I      intronic chr6:56979951(+) A-I      intronic chr6:56979989(+) A-I      intronic chr6:56980005(+) A-I      intronic chr6:56980009(+) A-I      intronic chr6:56981078(+) A-I      intronic chr6:56981234(+) A-I      intronic chr6:56981274(+) A-I      intronic chr6:57025307(+) A-I      intronic chr6:56983398(+) A-I      intronic chr6:56983415(+) A-I      intronic chr6:56983420(+) A-I      intronic chr6:56983516(+) A-I      intronic chr6:56983534(+) A-I      intronic chr6:56984070(+) A-I      intronic chr6:56984110(+) A-I      intronic chr6:56984138(+) A-I      intronic chr6:56984139(+) A-I      intronic chr6:56984174(+) A-I      intronic chr6:56984203(+) A-I      intronic chr6:56984267(+) A-I      intronic chr6:56984272(+) A-I      intronic chr6:56984310(+) A-I      intronic chr6:56987711(+) A-I      intronic chr6:56987723(+) A-I      intronic chr6:56987766(+) A-I      intronic chr6:56987859(+) A-I      intronic chr6:56987954(+) A-I      intronic chr6:57025316(+) A-I      intronic chr6:57020074(+) A-I      intronic chr6:57020082(+) A-I      intronic chr6:57020085(+) A-I      intronic chr6:57020108(+) A-I      intronic chr6:57020109(+) A-I      intronic chr6:57020119(+) A-I      intronic chr6:57020124(+) A-I      intronic chr6:57020137(+) A-I      intronic chr6:57020190(+) A-I      intronic chr6:57020209(+) A-I      intronic chr6:57025152(+) A-I      intronic chr6:57025154(+) A-I      intronic chr6:57025322(+) A-I      intronic chr6:57025183(+) A-I      intronic chr6:57025354(+) A-I      intronic chr6:57025395(+) A-I      intronic chr6:57028447(+) A-I      intronic chr6:57025355(+) A-I      intronic chr6:57025362(+) A-I      intronic chr6:57025380(+) A-I      intronic chr6:57020180(+) A-I      intronic chr6:57025187(+) A-I      intronic chr6:57025201(+) A-I      intronic chr6:57025218(+) A-I      intronic chr6:57025231(+) A-I      intronic chr6:57025232(+) A-I      intronic chr6:57025298(+) A-I      intronic chr6:57003655(+) A-I      intronic chr6:57003650(+) A-I      intronic chr6:56972880(+) A-I      3'UTR chr6:56972835(+) A-I      3'UTR chr6:57020126(+) A-I      intronic chr6:57025367(+) A-I      intronic chr6:57025249(+) A-I      intronic chr6:56978626(+) A-I      intronic chr6:57025289(+) A-I      intronic chr6:57009543(+) A-I      intronic chr6:57009133(+) A-I      intronic chr6:56979786(+) A-I      intronic chr6:56983380(+) A-I      intronic chr6:56963031(+) A-I      intronic chr6:57020122(+) A-I      intronic chr6:56978549(+) A-I      intronic chr6:57025206(+) A-I      intronic chr6:57025297(+) A-I      intronic chr6:56961245(+) A-I      intronic chr6:57020164(+) A-I      intronic chr6:56983310(+) A-I      intronic chr6:56972843(+) A-I      3'UTR chr6:56979784(+) A-I      intronic chr6:57025394(+) A-I      intronic chr6:56962951(+) A-I      intronic chr6:56963030(+) A-I      intronic chr6:57020123(+) A-I      intronic chr6:56963093(+) A-I      intronic chr6:57018446(+) A-I      intronic chr6:56981304(+) A-I      intronic chr6:56962948(+) A-I      intronic chr6:56983558(+) A-I      intronic chr6:56984166(+) A-I      intronic chr6:57025225(+) A-I      intronic chr6:56983381(+) A-I      intronic chr6:56963013(+) A-I      intronic chr6:56963032(+) A-I      intronic chr6:57004680(+) A-I      intronic chr6:56983410(+) A-I      intronic chr6:56978494(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ZNF451	chr6:56962948(+) A-G intron -    22484847 chr6:56962951(+) A-G intron -    22484847 chr6:56963013(+) A-G intron -    22484847 chr6:56963030(+) A-G intron -    22484847 chr6:56963031(+) A-G intron -    22484847 chr6:56963032(+) A-G intron -    22484847 chr6:56963093(+) A-G intron -    22484847 chr6:56971347(+) G-A intron -    22484847 chr6:56972655(+) G-T intron -    22484847 chr6:56972843(+) A-G intron -    22484847 chr6:56975716(+) C-T intron -    22484847 chr6:56976183(+) G-T intron -    22484847 chr6:56978494(+) A-G intron -    22484847 chr6:56978537(+) A-G intron -    22484847 chr6:56978549(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZNF451	chr6:56955010-56955011(+) m6A 5'UTR//exon//intron       24981863 chr6:56955049-56955050(+) m6A 5'UTR//exon//intron       24981863 chr6:56955058-56955059(+) m6A CDS//exon//intron       24981863 chr6:56965541-56965542(+) m6A CDS//exon//intron       24981863//22608085 chr6:56965557-56965558(+) m6A CDS//exon//intron       24284625//24981863//22575960//22608085 chr6:56965569-56965570(+) m6A CDS//exon//intron       24284625//24981863//22575960//22608085 chr6:56965613-56965614(+) m6A CDS//intron       24284625//24981863//22575960//22608085 chr6:56965619-56965620(+) m6A CDS//intron       24284625//24209618//24981863//22575960//22608085 chr6:56965646-56965647(+) m6A CDS//intron       24284625//24209618//24981863//22575960//22608085 chr6:56965772-56965773(+) m6A CDS//intron       24284625//24209618//24981863//22608085 chr6:56965857-56965858(+) m6A CDS//intron       24284625//24981863//22608085 chr6:56965875-56965876(+) m6A CDS//intron       24284625//24981863//22608085 chr6:56965922-56965923(+) m6A CDS//intron       24284625//24981863//22608085 chr6:56966011-56966012(+) m6A CDS//intron       24284625//24981863//22608085 chr6:56966071-56966072(+) m6A CDS//intron       24284625//24981863//22608085 chr6:56966154-56966155(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr6:56966188-56966189(+) m6A CDS//intron       24284625//24209618//24981863//22575960//22608085 chr6:56966214-56966215(+) m6A CDS//intron       24284625//24209618//24981863//22575960//22608085 chr6:56966235-56966236(+) m6A CDS//intron       24284625//24209618//24981863//22575960//22608085 chr6:56966272-56966273(+) m6A CDS//intron       24284625//24981863//22575960//22608085 chr6:56966289-56966290(+) m6A CDS//intron       24284625//24981863//22575960//22608085 chr6:56966416-56966417(+) m6A CDS//intron       24284625//24209618//24981863//22575960//22608085 chr6:56966427-56966428(+) m6A CDS//intron       24284625//24209618//24981863//22575960//22608085 chr6:56966532-56966533(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr6:56966541-56966542(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr6:56966574-56966575(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr6:56966621-56966622(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr6:56966671-56966672(+) m6A CDS//intron       24284625//24981863//22575960//22608085 chr6:56966700-56966701(+) m6A CDS//intron       24981863//22575960//22608085 chr6:56966824-56966825(+) m6A CDS//intron       24209618//24981863//22608085 chr6:56966832-56966833(+) m6A CDS//intron       24209618//24981863//22608085 chr6:56966862-56966863(+) m6A CDS//intron       24209618//24981863//22608085 chr6:56966996-56966997(+) m6A 3'UTR//intron       24284625//24209618//24981863//22575960//22608085 chr6:56967042-56967043(+) m6A 3'UTR//intron       24284625//24209618//24981863//22575960//22608085 chr6:56967071-56967072(+) m6A 3'UTR//intron       24284625//24209618//24981863//22575960//22608085 chr6:56967104-56967105(+) m6A 3'UTR//intron       24284625//24209618//24981863//22575960//22608085 chr6:56967123-56967124(+) m6A 3'UTR//intron       24284625//24981863//22575960//22608085 chr6:56967171-56967172(+) m6A 3'UTR//intron       24981863//22575960//22608085 chr6:56967248-56967249(+) m6A 3'UTR//intron       24981863//22608085 chr6:56967255-56967256(+) m6A 3'UTR//intron       24981863//22608085 chr6:56967304-56967305(+) m6A 3'UTR//intron       24981863//22608085 chr6:56967457-56967458(+) m6A 3'UTR//exon//intron       24284625//24981863//22575960//22608085 chr6:56967565-56967566(+) m6A 3'UTR//exon//intron       24284625//24209618//24981863//22575960//22608085 chr6:56967582-56967583(+) m6A 3'UTR//exon//intron       24284625//24209618//24981863//22575960//22608085 chr6:56967635-56967636(+) m6A 3'UTR//exon//intron       24284625//24209618//24981863//22575960//22608085 chr6:56967748-56967749(+) m6A 3'UTR//intron       24284625//24209618//24981863//22575960//22608085 chr6:56967807-56967808(+) m6A 3'UTR//intron       24284625//24209618//24981863//22608085 chr6:56967823-56967824(+) m6A 3'UTR//intron       24284625//24209618//24981863//22608085 chr6:56967935-56967936(+) m6A 3'UTR//intron       24209618//24981863//22575960//22608085 chr6:56967944-56967945(+) m6A 3'UTR//intron       24209618//24981863//22575960//22608085 chr6:56967958-56967959(+) m6A 3'UTR//intron       24981863//22575960//22608085 chr6:56968068-56968069(+) m6A 3'UTR//intron       22608085 chr6:56968203-56968204(+) m6A 3'UTR//intron       24981863//22608085 chr6:56968259-56968260(+) m6A 3'UTR//intron       24981863//22608085 chr6:56968308-56968309(+) m6A 3'UTR//intron       24981863//22608085 chr6:56968441-56968442(+) m6A 3'UTR//intron       24981863//22608085 chr6:56993582-56993583(+) m6A 3'UTR//5'UTR//CDS//exon//intron       24981863 chr6:56993606-56993607(+) m6A 3'UTR//5'UTR//CDS//exon//intron       24981863 chr6:56993617-56993618(+) m6A 3'UTR//5'UTR//CDS//exon//intron       24981863 chr6:56997847-56997848(+) m6A 3'UTR//CDS//exon//intron       24981863 chr6:56997868-56997869(+) m6A 3'UTR//CDS//exon//intron       24981863 chr6:57011908-57011909(+) m6A CDS//exon//intron       24284625 chr6:57011919-57011920(+) Tm CDS//exon//intron       - chr6:57012005-57012006(+) m6A CDS//exon//intron       24284625//24981863//22608085 chr6:57012037-57012038(+) m6A CDS//exon//intron       24284625//24981863//22608085 chr6:57012105-57012106(+) m6A CDS//exon//intron       24284625//24981863//22608085 chr6:57012170-57012171(+) m6A CDS//exon//intron       24284625//24981863//22608085 chr6:57012293-57012294(+) m6A CDS//exon//intron       24284625//24209618//24981863//22608085 chr6:57012363-57012364(+) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr6:57012485-57012486(+) m6A CDS//exon//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr6:57012550-57012551(+) m6A CDS//exon//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr6:57012590-57012591(+) m6A CDS//exon//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr6:57012748-57012749(+) m6A CDS//exon//intron       24284625//24209618//24981863//22575960//22608085 chr6:57012830-57012831(+) m6A CDS//exon//intron       24284625//24981863//22608085 chr6:57012983-57012984(+) m6A CDS//exon//intron       24284625//24981863//26404942//27773535//22608085 chr6:57012989-57012990(+) m6A CDS//exon//intron       24284625//24981863//26404942//27773535//22608085 chr6:57013001-57013002(+) m6A CDS//exon//intron       24284625//24981863//27773535//22608085 chr6:57013028-57013029(+) m6A CDS//exon//intron       24284625//24981863//22608085 chr6:57013132-57013133(+) m6A CDS//exon//intron       24284625//24981863//22608085 chr6:57013188-57013189(+) m6A CDS//exon//intron       24284625//24209618//24981863//22575960//22608085 chr6:57013315-57013316(+) m6A CDS//exon//intron       24284625//24981863//27773535//22575960//22608085 chr6:57013333-57013334(+) m6A CDS//exon//intron       24284625//24981863//27773535//22575960//22608085 chr6:57013368-57013369(+) m6A CDS//exon//intron       24284625//24981863//27773535//22575960//22608085 chr6:57013411-57013412(+) m6A CDS//exon//intron       24284625//24981863//27773535//22608085 chr6:57013417-57013418(+) m6A CDS//exon//intron       24284625//24981863//27773535//22608085 chr6:57013428-57013429(+) m6A CDS//exon//intron       24284625//24981863//27773535//22608085 chr6:57013446-57013447(+) m6A CDS//exon//intron       24284625//24981863//27773535//22608085 chr6:57015557-57015558(+) m6A CDS//exon//intron       24981863//22608085 chr6:57018754-57018755(+) m6A CDS//exon//intron       27773535 chr6:57018779-57018780(+) m6A CDS//exon//intron       27773535 chr6:57034669-57034670(+) m6A 3'UTR       24981863//27773535 chr6:57034676-57034677(+) m6A 3'UTR       24981863//27773535 chr6:57034766-57034767(+) m6A 3'UTR       24981863//27773535 chr6:57034808-57034809(+) m6A 3'UTR       24981863//27773535 chr6:57034875-57034876(+) m6A 3'UTR       24981863//27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-let-7g-3p	Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Serum     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cerebrospinal fluid     24797360 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -
	ZNF451	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-let-7g-3p
Interactor2: ZNF451

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.