Detail Information

Basic Information:


  VIRBase ID:  

HHID00065635

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-let-7g-3p:           PRPF8:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-let-7g-3p PRPF8
miRBase
Accession/Entrez ID		 MIMAT0004584 10594
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - HPRP8//PRP8//PRPC8//RP13//SNRNP220

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-let-7g-3p
rs1022640944 chr3:52268290    G/A
rs1166657040 chr3:52268299    A/G
rs1356748432 chr3:52268293    C/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PRPF8
chr17:1565653(-) A-I      intronic
chr17:1565638(-) A-I      intronic
chr17:1574790(-) A-I      intronic
chr17:1575680(-) A-I      intronic
chr17:1575768(-) A-I      intronic
chr17:1565665(-) A-I      intronic
chr17:1569028(-) A-I      intronic
chr17:1575666(-) A-I      intronic
chr17:1572671(-) A-I      intronic
chr17:1572650(-) A-I      intronic
chr17:1572477(-) A-I      intronic
chr17:1569024(-) A-I      intronic
chr17:1575781(-) A-I      intronic
chr17:1569018(-) A-I      intronic
chr17:1568652(-) A-I      intronic
chr17:1568604(-) A-I      intronic
chr17:1567883(-) A-I      intronic
chr17:1575045(-) A-I      intronic
chr17:1574911(-) A-I      intronic
chr17:1574830(-) A-I      intronic
chr17:1574807(-) A-I      intronic
chr17:1567599(-) A-I      intronic
chr17:1567457(-) A-I      intronic
chr17:1578154(-) A-I      intronic
chr17:1573848(-) A-I      intronic
chr17:1571785(-) A-I      intronic
chr17:1567489(-) A-I      intronic
chr17:1575712(-) A-I      intronic
chr17:1571002(-) A-I      intronic
chr17:1567463(-) A-I      intronic
chr17:1568644(-) A-I      intronic
chr17:1571935(-) A-I      intronic
chr17:1570415(-) A-I      intronic
chr17:1575743(-) A-I      intronic
chr17:1570910(-) A-I      intronic
chr17:1567526(-) A-I      intronic
chr17:1573918(-) A-I      intronic
chr17:1575702(-) A-I      intronic
chr17:1570367(-) A-I      intronic
chr17:1567495(-) A-I      intronic
chr17:1567400(-) A-I      intronic
chr17:1575742(-) A-I      intronic
chr17:1575738(-) A-I      intronic
chr17:1566818(-) A-I      intronic
chr17:1568720(-) A-I      intronic
chr17:1574844(-) A-I      intronic
chr17:1570423(-) A-I      intronic
chr17:1575767(-) A-I      intronic
chr17:1574889(-) A-I      intronic
chr17:1570966(-) A-I      intronic
chr17:1581424(-) A-I      intronic
chr17:1571929(-) A-I      intronic
chr17:1566908(-) A-I      intronic
chr17:1566956(-) A-I      intronic
chr17:1574793(-) A-I      intronic
chr17:1577389(-) A-I      intronic
chr17:1571853(-) A-I      intronic
chr17:1575814(-) A-I      intronic
chr17:1569276(-) A-I      intronic
chr17:1581738(-) A-I      intronic
chr17:1570380(-) A-I      intronic
chr17:1574898(-) A-I      intronic
chr17:1567471(-) A-I      intronic
chr17:1566821(-) A-I      intronic
chr17:1575980(-) A-I      intronic
chr17:1568806(-) A-I      intronic
chr17:1571227(-) A-I      intronic
chr17:1575033(-) A-I      intronic
chr17:1566926(-) A-I      intronic
chr17:1570448(-) A-I      intronic
chr17:1570952(-) A-I      intronic
chr17:1568786(-) A-I      intronic
chr17:1570381(-) A-I      intronic
chr17:1568769(-) A-I      intronic
chr17:1574956(-) A-I      intronic
chr17:1575711(-) A-I      intronic
chr17:1574583(-) A-I      intronic
chr17:1568785(-) A-I      intronic
chr17:1571244(-) A-I      intronic
chr17:1568881(-) A-I      intronic
chr17:1555689(-) A-I      intronic
chr17:1570212(-) A-I      intronic
chr17:1567422(-) A-I      intronic
chr17:1574053(-) A-I      intronic
chr17:1571406(-) A-I      intronic
chr17:1566920(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED PRPF8
chr17:1570212(-) A-G intron -    22484847
chr17:1571656(-) A-C intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PRPF8
chr17:1554039-1554040(-) m6A 3'UTR//CDS       27773535
chr17:1554108-1554109(-) m6A CDS       27773535//22575960
chr17:1554120-1554121(-) Cm CDS       -
chr17:1554204-1554205(-) m6A CDS//exon//intron       24284625//27773535
chr17:1554415-1554416(-) m6A CDS//exon       24284625//27773535//22575960
chr17:1554460-1554461(-) m6A CDS//exon       24284625//22575960
chr17:1554526-1554527(-) m6A CDS//exon       24284625//22575960
chr17:1554532-1554533(-) m6A CDS//exon       24284625//22575960
chr17:1554726-1554727(-) m6A CDS//exon       26404942//22575960
chr17:1554838-1554839(-) m6A CDS//exon       22575960
chr17:1554985-1554986(-) m6A CDS//exon       22575960
chr17:1556906-1556907(-) m6A CDS//exon       27773535
chr17:1556945-1556946(-) m6A CDS//exon       26404942//27773535
chr17:1557086-1557087(-) m6A CDS//exon       26404942//27773535
chr17:1557101-1557102(-) m6A CDS//exon       26404942//27773535
chr17:1557107-1557108(-) m6A CDS//exon       26404942//27773535
chr17:1557167-1557168(-) m6A CDS//exon       26404942//27773535//22575960
chr17:1557192-1557193(-) m6A CDS//exon       26404942//27773535//22575960
chr17:1557200-1557201(-) m6A CDS//exon       26404942//27773535//22575960
chr17:1557215-1557216(-) Gm CDS//exon       -
chr17:1557271-1557272(-) m6A CDS//exon       26404942//27773535//22575960
chr17:1558698-1558699(-) Am CDS       -
chr17:1558741-1558742(-) m6A CDS       26404942//27773535
chr17:1558755-1558756(-) m6A CDS       26404942//27773535
chr17:1558760-1558761(-) m6A CDS       27773535
chr17:1558793-1558794(-) m6A CDS       27773535//22575960
chr17:1559702-1559703(-) m6A CDS       27773535
chr17:1559845-1559846(-) m6A CDS       22575960
chr17:1559951-1559952(-) m6A CDS       22575960
chr17:1560039-1560040(-) m6A CDS       27773535//22575960
chr17:1561564-1561565(-) m6A CDS       26404942//27773535
chr17:1561661-1561662(-) m6A CDS       26404942//27773535
chr17:1562731-1562732(-) m6A CDS       26404942
chr17:1562779-1562780(-) m6A CDS//exon       26404942//22575960
chr17:1562830-1562831(-) m6A CDS//exon       -
chr17:1562858-1562859(-) m6A exon//intron       -
chr17:1562893-1562894(-) m6A exon//intron       -
chr17:1562950-1562951(-) m6A exon//intron       -
chr17:1563212-1563213(-) m6A CDS//exon       24284625
chr17:1563243-1563244(-) m6A CDS//exon       24284625//26404942
chr17:1563258-1563259(-) m6A CDS//exon       24284625//26404942
chr17:1563280-1563281(-) m6A CDS//exon       24284625//26404942
chr17:1563735-1563736(-) m6A CDS//exon       24284625//26404942
chr17:1563843-1563844(-) m6A CDS//exon       24284625//26404942
chr17:1564049-1564050(-) m6A CDS//exon       26404942
chr17:1564054-1564055(-) m6A CDS//exon       26404942
chr17:1564260-1564261(-) m6A exon//intron       22575960
chr17:1564907-1564908(-) m6A CDS//exon//intron       26404942
chr17:1576652-1576653(-) Gm CDS//exon       -
chr17:1576765-1576766(-) m6A CDS       22575960
chr17:1576792-1576793(-) m6A CDS       22575960
chr17:1576831-1576832(-) m6A CDS       26404942//22575960
chr17:1576840-1576841(-) m6A CDS       26404942//22575960
chr17:1577053-1577054(-) m6A CDS       26404942//22575960
chr17:1577114-1577115(-) m6A CDS       26404942//27773535
chr17:1577162-1577163(-) m6A CDS       24981863//26404942//27773535
chr17:1577807-1577808(-) m6A CDS       24981863//27773535
chr17:1577966-1577967(-) m6A CDS//exon       27773535
chr17:1578467-1578468(-) m6A CDS//exon       27773535
chr17:1578500-1578501(-) m6A CDS//exon       27773535
chr17:1578601-1578602(-) Gm CDS//exon       -
chr17:1578653-1578654(-) m6A exon//intron       22575960
chr17:1578779-1578780(-) m6A exon//intron       22575960
chr17:1578947-1578948(-) m6A CDS       -
chr17:1578954-1578955(-) m6A CDS       -
chr17:1579017-1579018(-) m6A CDS       26404942//22575960
chr17:1579322-1579323(-) Cm CDS       -
chr17:1579330-1579331(-) m6A CDS       26404942//22575960
chr17:1579825-1579826(-) m6A CDS//exon       27773535//22575960
chr17:1579878-1579879(-) m6A CDS//exon       27773535//22575960
chr17:1579883-1579884(-) m6A CDS//exon       27773535//22575960
chr17:1579935-1579936(-) m6A CDS//exon       27773535//22575960
chr17:1580328-1580329(-) m6A CDS//exon       22575960
chr17:1580339-1580340(-) m6A CDS//exon       22575960
chr17:1580366-1580367(-) m6A CDS//exon       22575960
chr17:1580439-1580440(-) m6A CDS//exon       27773535//22575960
chr17:1580480-1580481(-) m6A exon//intron       27773535//22575960
chr17:1580523-1580524(-) m6A exon//intron       27773535//22575960
chr17:1582353-1582354(-) m6A CDS//exon       26404942
chr17:1582374-1582375(-) m6A CDS//exon       26404942
chr17:1582905-1582906(-) m6A CDS       22575960
chr17:1582923-1582924(-) m6A CDS       26404942//22575960
chr17:1583004-1583005(-) m6A CDS       26404942//27773535//22575960
chr17:1583022-1583023(-) m6A CDS       26404942//27773535//22575960
chr17:1583084-1583085(-) m6A CDS       27773535
chr17:1583813-1583814(-) m6A exon//intron       27773535
chr17:1584093-1584094(-) m6A CDS//exon       27773535
chr17:1584339-1584340(-) m6A CDS       26404942//27773535
chr17:1584783-1584784(-) m6A CDS       26404942//27773535
chr17:1584797-1584798(-) m6A CDS       26404942//27773535
chr17:1585122-1585123(-) m6A CDS       22575960
chr17:1585152-1585153(-) m6A CDS       22575960
chr17:1585179-1585180(-) m6A CDS       22575960
chr17:1585236-1585237(-) m6A CDS       22575960
chr17:1585299-1585300(-) Gm CDS       -
chr17:1585542-1585543(-) m6A CDS//intron       22575960
chr17:1585553-1585554(-) m6A CDS//intron       22575960
chr17:1586871-1586872(-) m6A CDS//exon       22575960
chr17:1586880-1586881(-) m6A CDS//exon       22575960
chr17:1586903-1586904(-) m6A CDS//exon       22575960
chr17:1586916-1586917(-) m6A CDS//exon       22575960
chr17:1586926-1586927(-) Cm CDS//exon       -
chr17:1587797-1587798(-) m6A CDS//exon       22575960
chr17:1587968-1587969(-) m6A 5'UTR//intron       24284625//24981863
chr17:1588173-1588174(-) m6A 5'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-let-7g-3p
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Serum     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cerebrospinal fluid     24797360
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -
PRPF8
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Exosome Blood     -
Insoluble cytoplasm K562 cells     -
Membrane HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-let-7g-3p
Interactor2: PRPF8

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region CDS
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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