Detail Information

Basic Information:


  VIRBase ID:  

HHID00065625

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-let-7g-3p:           KLF10:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-let-7g-3p KLF10
miRBase
Accession/Entrez ID		 MIMAT0004584 7071
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - EGR-alpha//EGRA//TIEG//TIEG1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-let-7g-3p
rs1022640944 chr3:52268290    G/A
rs1166657040 chr3:52268299    A/G
rs1356748432 chr3:52268293    C/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR KLF10
chr8:103662906(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase KLF10
chr8:103661813-103661814(-) m6A 3'UTR       26404942
chr8:103661937-103661938(-) m6A 3'UTR       26404942
chr8:103661951-103661952(-) m6A 3'UTR       26404942
chr8:103662017-103662018(-) m6A 3'UTR       26404942
chr8:103662334-103662335(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr8:103662355-103662356(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr8:103662426-103662427(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr8:103662538-103662539(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr8:103662548-103662549(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr8:103662557-103662558(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr8:103663424-103663425(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22608085
chr8:103663539-103663540(-) m6A CDS       24284625//24209618//24981863//27773535
chr8:103663915-103663916(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr8:103663936-103663937(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr8:103663963-103663964(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr8:103663994-103663995(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22608085
chr8:103664014-103664015(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//22608085
chr8:103664054-103664055(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//22608085
chr8:103664121-103664122(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr8:103664178-103664179(-) m6A CDS       24284625//24209618//24981863//26404942//27773535
chr8:103664253-103664254(-) m6A CDS       24284625//27773535
chr8:103667798-103667799(-) m6A CDS       27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-let-7g-3p
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Serum     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cerebrospinal fluid     24797360
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -
KLF10
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-let-7g-3p
Interactor2: KLF10

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region CDS
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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