Basic Information:

  VIRBase ID:  

HHID00065624

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-let-7g-3p:  MIMAT0004584          ACSM3:  NM_202000     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-let-7g-3p	ACSM3
miRBase Accession/Entrez ID	MIMAT0004584	6296
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	SA//SAH

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-let-7g-3p	rs1022640944 chr3:52268290    G/A rs1166657040 chr3:52268299    A/G rs1356748432 chr3:52268293    C/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ACSM3	chr16:20790137(+) A-I      intronic chr16:20797838(+) A-I      intronic chr16:20797898(+) A-I      intronic chr16:20790543(+) A-I      intronic chr16:20806577(+) A-I      intronic chr16:20790491(+) A-I      intronic chr16:20801114(+) A-I      intronic chr16:20801230(+) A-I      intronic chr16:20801179(+) A-I      intronic chr16:20801097(+) A-I      intronic chr16:20775777(+) A-I      intronic chr16:20801137(+) A-I      intronic chr16:20775881(+) A-I      intronic chr16:20775890(+) A-I      intronic chr16:20775989(+) A-I      intronic chr16:20775990(+) A-I      intronic chr16:20801101(+) A-I      intronic chr16:20790544(+) A-I      intronic chr16:20790490(+) A-I      intronic chr16:20777957(+) A-I      intronic chr16:20790488(+) A-I      intronic chr16:20790503(+) A-I      intronic chr16:20806578(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ACSM3	chr16:20790210(+) T-C intron -    22484847 chr16:20790227(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ACSM3	chr16:20690519-20690520(+) m6A exon//intron       - chr16:20690569-20690570(+) m6A exon//intron       - chr16:20690593-20690594(+) m6A exon//intron       - chr16:20690626-20690627(+) m6A exon//intron       - chr16:20775344-20775345(+) m6A 5'UTR//intron       24981863 chr16:20775373-20775374(+) m6A 5'UTR//intron       24981863 chr16:20807641-20807642(+) m6A exon//intron       27773535 chr16:20807744-20807745(+) m6A CDS//exon       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-let-7g-3p	Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Serum     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cerebrospinal fluid     24797360 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -
	ACSM3	Cytosol HCC cell line (HepG2)|K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-let-7g-3p
Interactor2: ACSM3

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.