Basic Information:

  VIRBase ID:  

HHID00065621

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-let-7g-3p:  MIMAT0004584          OSBP:  NM_002556     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-let-7g-3p	OSBP
miRBase Accession/Entrez ID	MIMAT0004584	5007
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	OSBP1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-let-7g-3p	rs1022640944 chr3:52268290    G/A rs1166657040 chr3:52268299    A/G rs1356748432 chr3:52268293    C/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	OSBP	chr11:59351503(-) A-I      intronic chr11:59351490(-) A-I      intronic chr11:59351289(-) A-I      intronic chr11:59354906(-) A-I      intronic chr11:59356852(-) A-I      intronic chr11:59357276(-) A-I      intronic chr11:59350666(-) A-I      intronic chr11:59356911(-) A-I      intronic chr11:59351283(-) A-I      intronic chr11:59356660(-) A-I      intronic chr11:59350641(-) A-I      intronic chr11:59350723(-) A-I      intronic chr11:59351214(-) A-I      intronic chr11:59356930(-) A-I      intronic chr11:59360543(-) A-I      intronic chr11:59371265(-) A-I      intronic chr11:59356919(-) A-I      intronic chr11:59351225(-) A-I      intronic chr11:59351242(-) A-I      intronic chr11:59360377(-) A-I      intronic chr11:59357253(-) A-I      intronic chr11:59360329(-) A-I      intronic chr11:59347322(-) A-I      intronic chr11:59351246(-) A-I      intronic chr11:59351286(-) A-I      intronic chr11:59356220(-) A-I      intronic chr11:59351306(-) A-I      intronic chr11:59370272(-) A-I      intronic chr11:59360397(-) A-I      intronic chr11:59351326(-) A-I      intronic chr11:59351516(-) A-I      intronic chr11:59370335(-) A-I      intronic chr11:59370330(-) A-I      intronic chr11:59351521(-) A-I      intronic chr11:59365387(-) A-I      intronic chr11:59364750(-) A-I      intronic chr11:59351534(-) A-I      intronic chr11:59364702(-) A-I      intronic chr11:59351557(-) A-I      intronic chr11:59363247(-) A-I      intronic chr11:59355952(-) A-I      intronic chr11:59364700(-) A-I      intronic chr11:59360366(-) A-I      intronic chr11:59360273(-) A-I      intronic chr11:59356711(-) A-I      intronic chr11:59351597(-) A-I      intronic chr11:59371174(-) A-I      intronic chr11:59363334(-) A-I      intronic chr11:59356253(-) A-I      intronic chr11:59350722(-) A-I      intronic chr11:59360270(-) A-I      intronic chr11:59359361(-) A-I      intronic chr11:59355887(-) A-I      intronic chr11:59356359(-) A-I      intronic chr11:59351565(-) A-I      intronic chr11:59363287(-) A-I      intronic chr11:59363210(-) A-I      intronic chr11:59355841(-) A-I      intronic chr11:59359205(-) A-I      intronic chr11:59363153(-) A-I      intronic chr11:59356891(-) A-I      intronic chr11:59363140(-) A-I      intronic chr11:59363138(-) A-I      intronic chr11:59359167(-) A-I      intronic chr11:59360522(-) A-I      intronic chr11:59359166(-) A-I      intronic chr11:59356490(-) A-I      intronic chr11:59355844(-) A-I      intronic chr11:59356707(-) A-I      intronic chr11:59360513(-) A-I      intronic chr11:59350566(-) A-I      intronic chr11:59360489(-) A-I      intronic chr11:59360560(-) A-I      intronic chr11:59360487(-) A-I      intronic chr11:59351132(-) A-I      intronic chr11:59356829(-) A-I      intronic chr11:59359156(-) A-I      intronic chr11:59351693(-) A-I      intronic chr11:59351619(-) A-I      intronic chr11:59355965(-) A-I      intronic chr11:59357410(-) A-I      intronic chr11:59355885(-) A-I      intronic chr11:59356952(-) A-I      intronic chr11:59360474(-) A-I      intronic chr11:59360447(-) A-I      intronic chr11:59360437(-) A-I      intronic chr11:59360415(-) A-I      intronic chr11:59363309(-) A-I      intronic chr11:59351281(-) A-I      intronic chr11:59351639(-) A-I      intronic chr11:59356908(-) A-I      intronic chr11:59356366(-) A-I      intronic chr11:59356882(-) A-I      intronic chr11:59364669(-) A-I      intronic chr11:59360490(-) A-I      intronic chr11:59360450(-) A-I      intronic chr11:59364755(-) A-I      intronic chr11:59364670(-) A-I      intronic chr11:59356378(-) A-I      intronic chr11:59351202(-) A-I      intronic chr11:59350690(-) A-I      intronic chr11:59371192(-) A-I      intronic chr11:59357228(-) A-I      intronic chr11:59351273(-) A-I      intronic chr11:59351277(-) A-I      intronic chr11:59363245(-) A-I      intronic chr11:59360297(-) A-I      intronic chr11:59355881(-) A-I      intronic chr11:59356727(-) A-I      intronic chr11:59351316(-) A-I      intronic chr11:59356222(-) A-I      intronic chr11:59355824(-) A-I      intronic chr11:59360449(-) A-I      intronic chr11:59356356(-) A-I      intronic chr11:59357213(-) A-I      intronic chr11:59365233(-) A-I      intronic chr11:59357393(-) A-I      intronic chr11:59356734(-) A-I      intronic chr11:59357284(-) A-I      intronic chr11:59350618(-) A-I      intronic chr11:59351288(-) A-I      intronic chr11:59351628(-) A-I      intronic chr11:59351598(-) A-I      intronic chr11:59356313(-) A-I      intronic chr11:59360341(-) A-I      intronic chr11:59351383(-) A-I      intronic chr11:59351419(-) A-I      intronic chr11:59356656(-) A-I      intronic chr11:59350703(-) A-I      intronic chr11:59363295(-) A-I      intronic chr11:59357425(-) A-I      intronic chr11:59350702(-) A-I      intronic chr11:59357409(-) A-I      intronic chr11:59356669(-) A-I      intronic chr11:59356687(-) A-I      intronic chr11:59373132(-) A-I      intronic chr11:59356236(-) A-I      intronic chr11:59357067(-) A-I      intronic chr11:59360503(-) A-I      intronic chr11:59356257(-) A-I      intronic chr11:59356725(-) A-I      intronic chr11:59363335(-) A-I      intronic chr11:59363360(-) A-I      intronic chr11:59363304(-) A-I      intronic chr11:59351307(-) A-I      intronic chr11:59363191(-) A-I      intronic chr11:59351337(-) A-I      intronic chr11:59356906(-) A-I      intronic chr11:59351559(-) A-I      intronic chr11:59360475(-) A-I      intronic chr11:59359190(-) A-I      intronic chr11:59360544(-) A-I      intronic chr11:59360433(-) A-I      intronic chr11:59351213(-) A-I      intronic chr11:59355933(-) A-I      intronic chr11:59351340(-) A-I      intronic chr11:59357201(-) A-I      intronic chr11:59356261(-) A-I      intronic chr11:59351257(-) A-I      intronic chr11:59351252(-) A-I      intronic chr11:59350779(-) A-I      intronic chr11:59357399(-) A-I      intronic chr11:59357027(-) A-I      intronic chr11:59345981(-) A-I      intronic chr11:59351353(-) A-I      intronic chr11:59350621(-) A-I      intronic chr11:59357334(-) A-I      intronic chr11:59365460(-) A-I      intronic chr11:59363300(-) A-I      intronic chr11:59364696(-) A-I      intronic chr11:59354929(-) A-I      intronic chr11:59360407(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	OSBP	chr11:59351692(-) A-I intron -    21960545 chr11:59350566(-) A-G intron -    22484847 chr11:59351213(-) A-G intron -    22484847 chr11:59351597(-) A-G intron -    22484847 chr11:59351619(-) A-G intron -    22484847 chr11:59356222(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	OSBP	chr11:59343046-59343047(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr11:59343079-59343080(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr11:59343136-59343137(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr11:59343251-59343252(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr11:59343272-59343273(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr11:59343299-59343300(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr11:59343353-59343354(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr11:59343396-59343397(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr11:59343477-59343478(-) m6A 3'UTR       24284625//24209618//27773535//22608085 chr11:59343597-59343598(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr11:59343606-59343607(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr11:59343730-59343731(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr11:59343856-59343857(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr11:59343898-59343899(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr11:59344006-59344007(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr11:59344059-59344060(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr11:59344077-59344078(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr11:59344082-59344083(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr11:59344143-59344144(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr11:59344326-59344327(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr11:59344332-59344333(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr11:59344392-59344393(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22608085 chr11:59344417-59344418(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22608085 chr11:59344483-59344484(-) m6A 3'UTR//CDS       24209618//24981863//27371828//22608085 chr11:59347704-59347705(-) m6A 3'UTR//CDS       - chr11:59347711-59347712(-) m6A 3'UTR//CDS       - chr11:59361212-59361213(-) m6A exon//intron       - chr11:59368005-59368006(-) m6A CDS//exon       27773535 chr11:59368038-59368039(-) m6A CDS//exon       27773535 chr11:59368060-59368061(-) m6A CDS//exon       27773535 chr11:59368078-59368079(-) m6A CDS       27773535 chr11:59368294-59368295(-) m6A CDS       27773535 chr11:59368833-59368834(-) m6A CDS       27773535 chr11:59369141-59369142(-) m6A CDS       27773535 chr11:59376010-59376011(-) m6A CDS       27371828 chr11:59376119-59376120(-) m6A CDS       27371828 chr11:59376141-59376142(-) m6A CDS       27371828 chr11:59376165-59376166(-) m6A CDS       27371828 chr11:59376174-59376175(-) m6A CDS       27371828 chr11:59377893-59377894(-) m6A CDS       22575960 chr11:59377952-59377953(-) m6A CDS       24209618//27773535//22575960 chr11:59377990-59377991(-) m6A CDS       24209618//27773535 chr11:59378043-59378044(-) m6A CDS       24209618//27773535 chr11:59382777-59382778(-) Cm CDS       - chr11:59382842-59382843(-) m6A CDS       24209618//27773535 chr11:59383430-59383431(-) m6A 5'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-let-7g-3p	Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Serum     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cerebrospinal fluid     24797360 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -
	OSBP	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hsa-let-7g-3p
Interactor2: OSBP

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.