Basic Information:

  VIRBase ID:  

HHID00065618

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-let-7g-3p:  MIMAT0004584          KPNA2:  NM_002266     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-let-7g-3p	KPNA2
miRBase Accession/Entrez ID	MIMAT0004584	3838
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	IPOA1//QIP2//RCH1//SRP1-alpha//SRP1alpha

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-let-7g-3p	rs1022640944 chr3:52268290    G/A rs1166657040 chr3:52268299    A/G rs1356748432 chr3:52268293    C/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	KPNA2	chr17:66036487(+) A-I      intronic chr17:66036473(+) A-I      intronic chr17:66034298(+) A-I      intronic chr17:66035668(+) A-I      intronic chr17:66035420(+) A-I      intronic chr17:66035499(+) A-I      intronic chr17:66035376(+) A-I      intronic chr17:66037067(+) A-I      intronic chr17:66034438(+) A-I      intronic chr17:66036199(+) A-I      intronic chr17:66035471(+) A-I      intronic chr17:66034496(+) A-I      intronic chr17:66036043(+) A-I      intronic chr17:66034141(+) A-I      intronic chr17:66035735(+) A-I      intronic chr17:66035741(+) A-I      intronic chr17:66034943(+) A-I      intronic chr17:66036046(+) A-I      intronic chr17:66035808(+) A-I      intronic chr17:66035354(+) A-I      intronic chr17:66034735(+) A-I      intronic chr17:66037424(+) A-I      intronic chr17:66034018(+) A-I      intronic chr17:66035046(+) A-I      intronic chr17:66035817(+) A-I      intronic chr17:66036479(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	KPNA2	chr17:66031787-66031788(+) m6A 5'UTR       25456834//24981863 chr17:66031878-66031879(+) m6A 5'UTR       24284625//25456834//24981863//22575960 chr17:66033303-66033304(+) m6A CDS       24981863//27773535//22575960 chr17:66033315-66033316(+) m6A CDS       24981863//27773535//22575960 chr17:66033597-66033598(+) m6A 3'UTR//CDS       24981863 chr17:66038310-66038311(+) Y 3'UTR//CDS       26075521 chr17:66041908-66041909(+) m6A CDS//exon       27773535 chr17:66041916-66041917(+) m6A CDS//exon       27773535 chr17:66041951-66041952(+) m6A CDS//exon       27773535 chr17:66041972-66041973(+) m6A CDS//exon       27773535//22575960 chr17:66042649-66042650(+) m6A CDS//exon       27773535//22575960 chr17:66042726-66042727(+) m6A 3'UTR//exon       27773535 chr17:66042783-66042784(+) m6A 3'UTR       27773535 chr17:66042830-66042831(+) m6A 3'UTR       27773535 chr17:66042841-66042842(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-let-7g-3p	Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Serum     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cerebrospinal fluid     24797360 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -
	KPNA2	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome-free cytosol Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-let-7g-3p
Interactor2: KPNA2

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.