Basic Information:

  VIRBase ID:  

HHID00065601

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-223-5p:  MIMAT0004570          SLC35E4:  NM_001318371     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-223-5p	SLC35E4
miRBase Accession/Entrez ID	MIMAT0004570	339665
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-223-5p	rs1240009384 chrX:66018913    A/T rs1397275461 chrX:66018904    G/T rs1464475149 chrX:66018916    T/C rs761701581 chrX:66018906    C/G rs772305537 chrX:66018909    G/A rs774279244 chrX:66018895    C/T rs890919635 chrX:66018896    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SLC35E4	chr22:31043326(+) A-I      3'UTR chr22:31043335(+) A-I      3'UTR chr22:31043313(+) A-I      3'UTR chr22:31043334(+) A-I      3'UTR chr22:31036283(+) A-I      intronic chr22:31033404(+) A-I      intronic chr22:31033395(+) A-I      intronic chr22:31033390(+) A-I      intronic chr22:31033289(+) A-I      intronic chr22:31033391(+) A-I      intronic chr22:31038902(+) A-I      intronic chr22:31041439(+) A-I      intronic chr22:31041586(+) A-I      intronic chr22:31037748(+) A-I      intronic chr22:31038617(+) A-I      intronic chr22:31042024(+) A-I      intronic chr22:31037768(+) A-I      intronic chr22:31041740(+) A-I      intronic chr22:31034544(+) A-I      intronic chr22:31034097(+) A-I      intronic chr22:31033591(+) A-I      intronic chr22:31041660(+) A-I      intronic chr22:31041717(+) A-I      intronic chr22:31036270(+) A-I      intronic chr22:31036211(+) A-I      intronic chr22:31038225(+) A-I      intronic chr22:31041967(+) A-I      intronic chr22:31033524(+) A-I      intronic chr22:31043199(+) A-I      3'UTR chr22:31043206(+) A-I      3'UTR chr22:31043329(+) A-I      3'UTR chr22:31043287(+) A-I      3'UTR chr22:31043262(+) A-I      3'UTR chr22:31033454(+) A-I      intronic chr22:31033474(+) A-I      intronic chr22:31041327(+) A-I      intronic chr22:31040685(+) A-I      intronic chr22:31041946(+) A-I      intronic chr22:31034369(+) A-I      intronic chr22:31041435(+) A-I      intronic chr22:31036238(+) A-I      intronic chr22:31041908(+) A-I      intronic chr22:31033293(+) A-I      intronic chr22:31040620(+) A-I      intronic chr22:31038451(+) A-I      intronic chr22:31038649(+) A-I      intronic chr22:31041701(+) A-I      intronic chr22:31033430(+) A-I      intronic chr22:31033364(+) A-I      intronic chr22:31038092(+) A-I      intronic chr22:31033365(+) A-I      intronic chr22:31033342(+) A-I      intronic chr22:31041432(+) A-I      intronic chr22:31036264(+) A-I      intronic chr22:31033334(+) A-I      intronic chr22:31033587(+) A-I      intronic chr22:31041787(+) A-I      intronic chr22:31041503(+) A-I      intronic chr22:31041739(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SLC35E4	chr22:31032077-31032078(+) m6A 5'UTR       24284625//24981863 chr22:31032150-31032151(+) m6A 5'UTR       24284625//24209618//24981863//22608085 chr22:31032201-31032202(+) m6A 5'UTR       24284625//24209618//24981863//22608085 chr22:31032253-31032254(+) m6A 5'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr22:31032271-31032272(+) m6A 5'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr22:31032328-31032329(+) m6A 5'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr22:31032344-31032345(+) m6A 5'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr22:31032372-31032373(+) m6A 5'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr22:31032837-31032838(+) m6A CDS       24284625//24981863 chr22:31042995-31042996(+) m6A CDS//intron       25456834//24981863//22608085 chr22:31043019-31043020(+) m6A 3'UTR//intron       25456834//24981863//22608085 chr22:31043098-31043099(+) m6A 3'UTR//intron       25456834//24981863//22608085 chr22:31043366-31043367(+) m6A 3'UTR//intron       24284625//24209618//24981863//22608085 chr22:31043411-31043412(+) m6A 3'UTR//intron       24284625//25456834//24981863//22608085 chr22:31043489-31043490(+) m6A 3'UTR//intron       24284625//25456834//24981863//22608085 chr22:31043501-31043502(+) m6A 3'UTR//intron       24284625//25456834//24981863//22608085 chr22:31043540-31043541(+) m6A 3'UTR//intron       24284625//25456834//24981863//22608085 chr22:31058136-31058137(+) m6A 3'UTR//intron       24981863//27773535//22608085 chr22:31058270-31058271(+) m6A 3'UTR//intron       24209618//24981863 chr22:31058280-31058281(+) m6A 3'UTR//intron       24209618//24981863 chr22:31058380-31058381(+) m6A 3'UTR//intron       24284625//25456834//24981863//22608085 chr22:31058389-31058390(+) m6A 3'UTR//intron       24284625//25456834//24981863//22608085 chr22:31058433-31058434(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr22:31058487-31058488(+) m6A 3'UTR//intron       24284625//24981863 chr22:31058614-31058615(+) m6A 3'UTR//intron       24981863 chr22:31061506-31061507(+) m6A CDS       24981863//22608085 chr22:31063828-31063829(+) m6A 3'UTR       24981863//27371828 chr22:31064142-31064143(+) m6A 3'UTR       - chr22:31064168-31064169(+) m6A 3'UTR       - chr22:31064190-31064191(+) m6A 3'UTR       - chr22:31064265-31064266(+) m6A 3'UTR       - chr22:31064322-31064323(+) m6A 3'UTR       - chr22:31064330-31064331(+) m6A 3'UTR       - chr22:31064348-31064349(+) m6A 3'UTR       - chr22:31064358-31064359(+) m6A 3'UTR       - chr22:31064378-31064379(+) m6A 3'UTR       - chr22:31064461-31064462(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-223-5p	Exosome Primary dendritic cells     21505438 Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	SLC35E4	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-223-5p
Interactor2: SLC35E4

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.