Detail Information

Basic Information:


  VIRBase ID:  

HHID00065599

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-223-5p:           BRWD3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-223-5p BRWD3
miRBase
Accession/Entrez ID		 MIMAT0004570 254065
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - BRODL//MRX93

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-223-5p
rs1240009384 chrX:66018913    A/T
rs1397275461 chrX:66018904    G/T
rs1464475149 chrX:66018916    T/C
rs761701581 chrX:66018906    C/G
rs772305537 chrX:66018909    G/A
rs774279244 chrX:66018895    C/T
rs890919635 chrX:66018896    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR BRWD3
chrX:80051727(-) A-I      intronic
chrX:80003650(-) A-I      intronic
chrX:80006207(-) A-I      intronic
chrX:80051892(-) A-I      intronic
chrX:80051900(-) A-I      intronic
chrX:80058360(-) A-I      intronic
chrX:80045147(-) A-I      intronic
chrX:80051722(-) A-I      intronic
chrX:80051416(-) A-I      intronic
chrX:80049421(-) A-I      intronic
chrX:80045687(-) A-I      intronic
chrX:80045486(-) A-I      intronic
chrX:80007676(-) A-I      intronic
chrX:80045139(-) A-I      intronic
chrX:80045104(-) A-I      intronic
chrX:80045090(-) A-I      intronic
chrX:80045071(-) A-I      intronic
chrX:80045042(-) A-I      intronic
chrX:80045023(-) A-I      intronic
chrX:80045013(-) A-I      intronic
chrX:80042290(-) A-I      intronic
chrX:80042282(-) A-I      intronic
chrX:80042276(-) A-I      intronic
chrX:80042193(-) A-I      intronic
chrX:80041447(-) A-I      intronic
chrX:80041420(-) A-I      intronic
chrX:80041405(-) A-I      intronic
chrX:80041361(-) A-I      intronic
chrX:80038278(-) A-I      intronic
chrX:80038210(-) A-I      intronic
chrX:80035017(-) A-I      intronic
chrX:80034596(-) A-I      intronic
chrX:80033374(-) A-I      intronic
chrX:80033056(-) A-I      intronic
chrX:80033016(-) A-I      intronic
chrX:80016501(-) A-I      intronic
chrX:80010460(-) A-I      intronic
chrX:80010375(-) A-I      intronic
chrX:80010358(-) A-I      intronic
chrX:80010326(-) A-I      intronic
chrX:80010303(-) A-I      intronic
chrX:80010271(-) A-I      intronic
chrX:80008946(-) A-I      intronic
chrX:80052462(-) A-I      intronic
chrX:80051809(-) A-I      intronic
chrX:80051732(-) A-I      intronic
chrX:80008907(-) A-I      intronic
chrX:80008906(-) A-I      intronic
chrX:80008829(-) A-I      intronic
chrX:80008301(-) A-I      intronic
chrX:80007729(-) A-I      intronic
chrX:80007712(-) A-I      intronic
chrX:80045654(-) A-I      intronic
chrX:80042207(-) A-I      intronic
chrX:80033422(-) A-I      intronic
chrX:80033080(-) A-I      intronic
chrX:80008302(-) A-I      intronic
chrX:79969823(-) A-I      intronic
chrX:80016544(-) A-I      intronic
chrX:80057326(-) A-I      intronic
chrX:80057094(-) A-I      intronic
chrX:80007681(-) A-I      intronic
chrX:79991050(-) A-I      intronic
chrX:80035065(-) A-I      intronic
chrX:79963859(-) A-I      intronic
chrX:80042152(-) A-I      intronic
chrX:80010340(-) A-I      intronic
chrX:80010424(-) A-I      intronic
chrX:80034479(-) A-I      intronic
chrX:80045039(-) A-I      intronic
chrX:80034620(-) A-I      intronic
chrX:80029820(-) A-I      intronic
chrX:80045601(-) A-I      intronic
chrX:80010348(-) A-I      intronic
chrX:80045639(-) A-I      intronic
chrX:80056987(-) A-I      intronic
chrX:80041522(-) A-I      intronic
chrX:80035090(-) A-I      intronic
chrX:80057234(-) A-I      intronic
chrX:80033130(-) A-I      intronic
chrX:80056910(-) A-I      intronic
chrX:80053405(-) A-I      intronic
chrX:80051901(-) A-I      intronic
chrX:80059797(-) A-I      intronic
chrX:80045602(-) A-I      intronic
chrX:80010288(-) A-I      intronic
chrX:80010407(-) A-I      intronic
chrX:80016540(-) A-I      intronic
chrX:80042281(-) A-I      intronic
chrX:80045553(-) A-I      intronic
chrX:80041446(-) A-I      intronic
chrX:80041344(-) A-I      intronic
chrX:80045070(-) A-I      intronic
chrX:80057743(-) A-I      intronic
chrX:80056843(-) A-I      intronic
chrX:80014282(-) A-I      intronic
chrX:80033064(-) A-I      intronic
chrX:80059822(-) A-I      intronic
chrX:80051335(-) A-I      intronic
chrX:80029854(-) A-I      intronic
chrX:80045515(-) A-I      intronic
chrX:80045561(-) A-I      intronic
chrX:80052425(-) A-I      intronic
chrX:79963843(-) A-I      intronic
chrX:80041417(-) A-I      intronic
chrX:79969829(-) A-I      intronic
chrX:80035066(-) A-I      intronic
chrX:80045080(-) A-I      intronic
chrX:80042196(-) A-I      intronic
chrX:80045573(-) A-I      intronic
chrX:80034315(-) A-I      intronic
chrX:80009042(-) A-I      intronic
chrX:80041276(-) A-I      intronic
chrX:80035092(-) A-I      intronic
chrX:80033135(-) A-I      intronic
chrX:80007660(-) A-I      intronic
chrX:80051741(-) A-I      intronic
chrX:80016519(-) A-I      intronic
chrX:80045641(-) A-I      intronic
chrX:80045512(-) A-I      intronic
chrX:80045557(-) A-I      intronic
chrX:80056816(-) A-I      intronic
chrX:80059901(-) A-I      intronic
chrX:80032941(-) A-I      intronic
chrX:80042151(-) A-I      intronic
chrX:80061241(-) A-I      intronic
chrX:80034970(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED BRWD3
chrX:80006320(-) A-G intron -    22484847
chrX:80007627(-) A-G intron -    22484847
chrX:80041429(-) A-G intron -    22484847
chrX:80042110(-) A-G intron -    22484847
chrX:80042111(-) A-G intron -    22484847
chrX:80042196(-) A-G intron -    22484847
chrX:80042281(-) A-G intron -    22484847
chrX:80045601(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase BRWD3
chrX:79931816-79931817(-) m6A 3'UTR       24981863//22608085
chrX:79931827-79931828(-) m6A 3'UTR       24981863//22608085
chrX:79931842-79931843(-) m6A 3'UTR       24284625//24981863//22608085
chrX:79931870-79931871(-) m6A 3'UTR       24284625//24981863//22608085
chrX:79931956-79931957(-) m6A 3'UTR       24284625//22608085
chrX:79932016-79932017(-) m6A 3'UTR       22608085
chrX:79932176-79932177(-) Cm CDS       -
chrX:79932250-79932251(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//22608085
chrX:79932264-79932265(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//22575960//22608085
chrX:79932271-79932272(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//22575960//22608085
chrX:79932287-79932288(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//22575960//22608085
chrX:79932517-79932518(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//22608085
chrX:79932557-79932558(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//22575960//22608085
chrX:79932569-79932570(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//22575960//22608085
chrX:79932574-79932575(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//22575960//22608085
chrX:79932600-79932601(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//22575960//22608085
chrX:79932625-79932626(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//22575960//22608085
chrX:79932733-79932734(-) m6A CDS       24284625//24981863//28052920//27371828//22575960//22608085
chrX:79932765-79932766(-) m6A CDS//exon       24284625//24981863//28052920//27371828//22608085
chrX:79932794-79932795(-) m6A CDS//exon       24284625//24981863//28052920//27371828//22608085
chrX:79932811-79932812(-) m6A CDS//exon       24284625//24981863//28052920//27371828//22608085
chrX:79932845-79932846(-) m6A CDS//exon       24284625//24981863//27371828//22608085
chrX:79936843-79936844(-) m6A CDS//exon       24981863//22608085
chrX:79959083-79959084(-) m6A CDS//exon       24981863
chrX:79960187-79960188(-) m6A CDS//exon       24981863
chrX:79960197-79960198(-) m6A CDS//exon       24981863
chrX:79960269-79960270(-) m6A CDS//exon       24981863
chrX:79960278-79960279(-) m6A CDS//exon       24981863
chrX:79960316-79960317(-) m6A CDS//exon       24981863
chrX:79971729-79971730(-) m6A CDS//exon       24981863
chrX:79975048-79975049(-) m6A CDS//exon       24981863
chrX:79975055-79975056(-) m6A CDS//exon       24981863
chrX:79975060-79975061(-) m6A CDS//exon       24981863
chrX:79980471-79980472(-) m6A CDS       -
chrX:79980486-79980487(-) m6A CDS       -
chrX:79980563-79980564(-) m6A CDS       -
chrX:79985459-79985460(-) Am CDS       -
chrX:80064765-80064766(-) m6A CDS//exon       27773536
chrX:80065068-80065069(-) m6A 5'UTR//exon       -
chrX:80065100-80065101(-) m6A 5'UTR//exon       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-223-5p
Exosome Primary dendritic cells     21505438
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
BRWD3
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome HeLa cells     24205503
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-223-5p
Interactor2: BRWD3

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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