Basic Information:

  VIRBase ID:  

HHID00065592

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-223-5p:  MIMAT0004570          OSBPL8:  NM_001319655     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-223-5p	OSBPL8
miRBase Accession/Entrez ID	MIMAT0004570	114882
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	MST120//MSTP120//ORP8//OSBP10

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-223-5p	rs1240009384 chrX:66018913    A/T rs1397275461 chrX:66018904    G/T rs1464475149 chrX:66018916    T/C rs761701581 chrX:66018906    C/G rs772305537 chrX:66018909    G/A rs774279244 chrX:66018895    C/T rs890919635 chrX:66018896    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	OSBPL8	chr12:76868675(-) A-I      intronic chr12:76868668(-) A-I      intronic chr12:76799163(-) A-I      intronic chr12:76790692(-) A-I      intronic chr12:76868684(-) A-I      intronic chr12:76868683(-) A-I      intronic chr12:76881029(-) A-I      intronic chr12:76881024(-) A-I      intronic chr12:76920725(-) A-I      intronic chr12:76921929(-) A-I      intronic chr12:76921938(-) A-I      intronic chr12:76921944(-) A-I      intronic chr12:76924037(-) A-I      intronic chr12:76924055(-) A-I      intronic chr12:76931526(-) A-I      intronic chr12:76931606(-) A-I      intronic chr12:76943315(-) A-I      intronic chr12:76943319(-) A-I      intronic chr12:76944745(-) A-I      intronic chr12:76950559(-) A-I      intronic chr12:76950581(-) A-I      intronic chr12:76950582(-) A-I      intronic chr12:76950640(-) A-I      intronic chr12:76950700(-) A-I      intronic chr12:76951227(-) A-I      intronic chr12:76951333(-) A-I      intronic chr12:76951338(-) A-I      intronic chr12:76877244(-) A-I      intronic chr12:76876311(-) A-I      intronic chr12:76877262(-) A-I      intronic chr12:76877306(-) A-I      intronic chr12:76877682(-) A-I      intronic chr12:76877688(-) A-I      intronic chr12:76877697(-) A-I      intronic chr12:76877744(-) A-I      intronic chr12:76878777(-) A-I      intronic chr12:76878786(-) A-I      intronic chr12:76878797(-) A-I      intronic chr12:76878812(-) A-I      intronic chr12:76878816(-) A-I      intronic chr12:76878865(-) A-I      intronic chr12:76878870(-) A-I      intronic chr12:76878880(-) A-I      intronic chr12:76878885(-) A-I      intronic chr12:76878953(-) A-I      intronic chr12:76878967(-) A-I      intronic chr12:76878982(-) A-I      intronic chr12:76879141(-) A-I      intronic chr12:76879241(-) A-I      intronic chr12:76879271(-) A-I      intronic chr12:76880878(-) A-I      intronic chr12:76880882(-) A-I      intronic chr12:76880948(-) A-I      intronic chr12:76880974(-) A-I      intronic chr12:76880978(-) A-I      intronic chr12:76881030(-) A-I      intronic chr12:76881038(-) A-I      intronic chr12:76881048(-) A-I      intronic chr12:76881084(-) A-I      intronic chr12:76892602(-) A-I      intronic chr12:76892656(-) A-I      intronic chr12:76892678(-) A-I      intronic chr12:76892684(-) A-I      intronic chr12:76893227(-) A-I      intronic chr12:76893396(-) A-I      intronic chr12:76893428(-) A-I      intronic chr12:76893450(-) A-I      intronic chr12:76901875(-) A-I      intronic chr12:76910687(-) A-I      intronic chr12:76910697(-) A-I      intronic chr12:76910700(-) A-I      intronic chr12:76910718(-) A-I      intronic chr12:76910773(-) A-I      intronic chr12:76772671(-) A-I      intronic chr12:76772706(-) A-I      intronic chr12:76772726(-) A-I      intronic chr12:76910782(-) A-I      intronic chr12:76774303(-) A-I      intronic chr12:76775630(-) A-I      intronic chr12:76775631(-) A-I      intronic chr12:76910861(-) A-I      intronic chr12:76918601(-) A-I      intronic chr12:76775765(-) A-I      intronic chr12:76775766(-) A-I      intronic chr12:76776555(-) A-I      intronic chr12:76918602(-) A-I      intronic chr12:76776563(-) A-I      intronic chr12:76790296(-) A-I      intronic chr12:76918646(-) A-I      intronic chr12:76790364(-) A-I      intronic chr12:76790406(-) A-I      intronic chr12:76790451(-) A-I      intronic chr12:76790465(-) A-I      intronic chr12:76790512(-) A-I      intronic chr12:76799075(-) A-I      intronic chr12:76799139(-) A-I      intronic chr12:76801198(-) A-I      intronic chr12:76801199(-) A-I      intronic chr12:76920550(-) A-I      intronic chr12:76920554(-) A-I      intronic chr12:76802142(-) A-I      intronic chr12:76811954(-) A-I      intronic chr12:76812049(-) A-I      intronic chr12:76812064(-) A-I      intronic chr12:76920569(-) A-I      intronic chr12:76831971(-) A-I      intronic chr12:76831972(-) A-I      intronic chr12:76831995(-) A-I      intronic chr12:76837514(-) A-I      intronic chr12:76837557(-) A-I      intronic chr12:76842538(-) A-I      intronic chr12:76842618(-) A-I      intronic chr12:76842649(-) A-I      intronic chr12:76842736(-) A-I      intronic chr12:76842755(-) A-I      intronic chr12:76842786(-) A-I      intronic chr12:76852442(-) A-I      intronic chr12:76858053(-) A-I      intronic chr12:76858067(-) A-I      intronic chr12:76872835(-) A-I      intronic chr12:76873702(-) A-I      intronic chr12:76876177(-) A-I      intronic chr12:76876149(-) A-I      intronic chr12:76841484(-) A-I      intronic chr12:76772674(-) A-I      intronic chr12:76943328(-) A-I      intronic chr12:76772753(-) A-I      intronic chr12:76877736(-) A-I      intronic chr12:76812035(-) A-I      intronic chr12:76790418(-) A-I      intronic chr12:76877658(-) A-I      intronic chr12:76877092(-) A-I      intronic chr12:76951312(-) A-I      intronic chr12:76879205(-) A-I      intronic chr12:76809244(-) A-I      intronic chr12:76920568(-) A-I      intronic chr12:76878873(-) A-I      intronic chr12:76944742(-) A-I      intronic chr12:76774246(-) A-I      intronic chr12:76880958(-) A-I      intronic chr12:76790448(-) A-I      intronic chr12:76812040(-) A-I      intronic chr12:76801147(-) A-I      intronic chr12:76879266(-) A-I      intronic chr12:76877560(-) A-I      intronic chr12:76877537(-) A-I      intronic chr12:76944738(-) A-I      intronic chr12:76946084(-) A-I      intronic chr12:76877687(-) A-I      intronic chr12:76892597(-) A-I      intronic chr12:76872676(-) A-I      intronic chr12:76774224(-) A-I      intronic chr12:76809292(-) A-I      intronic chr12:76877527(-) A-I      intronic chr12:76877507(-) A-I      intronic chr12:76831864(-) A-I      intronic chr12:76876310(-) A-I      intronic chr12:76892638(-) A-I      intronic chr12:76790410(-) A-I      intronic chr12:76944826(-) A-I      intronic chr12:76790870(-) A-I      intronic chr12:76826360(-) A-I      intronic chr12:76876891(-) A-I      intronic chr12:76809287(-) A-I      intronic chr12:76893288(-) A-I      intronic chr12:76878882(-) A-I      intronic chr12:76772655(-) A-I      intronic chr12:76879253(-) A-I      intronic chr12:76923912(-) A-I      intronic chr12:76879267(-) A-I      intronic chr12:76877599(-) A-I      intronic chr12:76801146(-) A-I      intronic chr12:76877592(-) A-I      intronic chr12:76877727(-) A-I      intronic chr12:76893539(-) A-I      intronic chr12:76794636(-) A-I      intronic chr12:76832189(-) A-I      intronic chr12:76842741(-) A-I      intronic chr12:76877287(-) A-I      intronic chr12:76841528(-) A-I      intronic chr12:76772629(-) A-I      intronic chr12:76877583(-) A-I      intronic chr12:76877346(-) A-I      intronic chr12:76879089(-) A-I      intronic chr12:76811926(-) A-I      intronic chr12:76893625(-) A-I      intronic chr12:76851849(-) A-I      intronic chr12:76920711(-) A-I      intronic chr12:76951273(-) A-I      intronic chr12:76811868(-) A-I      intronic chr12:76790755(-) A-I      intronic chr12:76878994(-) A-I      intronic chr12:76841488(-) A-I      intronic chr12:76880883(-) A-I      intronic chr12:76890635(-) A-I      intronic chr12:76923888(-) A-I      intronic chr12:76790452(-) A-I      intronic chr12:76879195(-) A-I      intronic chr12:76922071(-) A-I      intronic chr12:76790390(-) A-I      intronic chr12:76877222(-) A-I      intronic chr12:76920468(-) A-I      intronic chr12:76772647(-) A-I      intronic chr12:76951260(-) A-I      intronic chr12:76790754(-) A-I      intronic chr12:76831797(-) A-I      intronic chr12:76893283(-) A-I      intronic chr12:76772732(-) A-I      intronic chr12:76910624(-) A-I      intronic chr12:76880877(-) A-I      intronic chr12:76879149(-) A-I      intronic chr12:76950549(-) A-I      intronic chr12:76892610(-) A-I      intronic chr12:76876779(-) A-I      intronic chr12:76877692(-) A-I      intronic chr12:76892615(-) A-I      intronic chr12:76880906(-) A-I      intronic chr12:76879270(-) A-I      intronic chr12:76794634(-) A-I      intronic chr12:76808293(-) A-I      intronic chr12:76893512(-) A-I      intronic chr12:76879180(-) A-I      intronic chr12:76772688(-) A-I      intronic chr12:76855268(-) A-I      intronic chr12:76931501(-) A-I      intronic chr12:76893468(-) A-I      intronic chr12:76904497(-) A-I      intronic chr12:76880844(-) A-I      intronic chr12:76881106(-) A-I      intronic chr12:76868769(-) A-I      intronic chr12:76808512(-) A-I      intronic chr12:76880907(-) A-I      intronic chr12:76918728(-) A-I      intronic chr12:76920503(-) A-I      intronic chr12:76946094(-) A-I      intronic chr12:76808327(-) A-I      intronic chr12:76876892(-) A-I      intronic chr12:76879244(-) A-I      intronic chr12:76877098(-) A-I      intronic chr12:76799838(-) A-I      intronic chr12:76790697(-) A-I      intronic chr12:76877261(-) A-I      intronic chr12:76877176(-) A-I      intronic chr12:76951391(-) A-I      intronic chr12:76893374(-) A-I      intronic chr12:76776624(-) A-I      intronic chr12:76951229(-) A-I      intronic chr12:76877619(-) A-I      intronic chr12:76868657(-) A-I      intronic chr12:76877179(-) A-I      intronic chr12:76890258(-) A-I      intronic chr12:76880938(-) A-I      intronic chr12:76923905(-) A-I      intronic chr12:76842762(-) A-I      intronic chr12:76809223(-) A-I      intronic chr12:76880987(-) A-I      intronic chr12:76876995(-) A-I      intronic chr12:76922031(-) A-I      intronic chr12:76950540(-) A-I      intronic chr12:76878876(-) A-I      intronic chr12:76921932(-) A-I      intronic chr12:76841616(-) A-I      intronic chr12:76878868(-) A-I      intronic chr12:76832910(-) A-I      intronic chr12:76951283(-) A-I      intronic chr12:76877593(-) A-I      intronic chr12:76790425(-) A-I      intronic chr12:76944684(-) A-I      intronic chr12:76921846(-) A-I      intronic chr12:76868757(-) A-I      intronic chr12:76904494(-) A-I      intronic chr12:76910867(-) A-I      intronic chr12:76877108(-) A-I      intronic chr12:76878930(-) A-I      intronic chr12:76831483(-) A-I      intronic chr12:76877633(-) A-I      intronic chr12:76922001(-) A-I      intronic chr12:76921858(-) A-I      intronic chr12:76924117(-) A-I      intronic chr12:76774263(-) A-I      intronic chr12:76877728(-) A-I      intronic chr12:76893289(-) A-I      intronic chr12:76879258(-) A-I      intronic chr12:76812611(-) A-I      intronic chr12:76877520(-) A-I      intronic chr12:76950647(-) A-I      intronic chr12:76879186(-) A-I      intronic chr12:76877552(-) A-I      intronic chr12:76811923(-) A-I      intronic chr12:76915516(-) A-I      intronic chr12:76811924(-) A-I      intronic chr12:76950474(-) A-I      intronic chr12:76910731(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	OSBPL8	chr12:76876149(-) A-I intron -    15545495 chr12:76799838(-) A-G intron -    22484847 chr12:76877736(-) A-G intron -    22484847 chr12:76893289(-) A-G intron -    22484847 chr12:76766204(-) T-C intron -    22484847 chr12:76772674(-) A-G intron -    22484847 chr12:76772732(-) A-G intron -    22484847 chr12:76774246(-) A-G intron -    22484847 chr12:76774263(-) A-G intron -    22484847 chr12:76790390(-) A-G intron -    22484847 chr12:76790410(-) A-G intron -    22484847 chr12:76790418(-) A-G intron -    22484847 chr12:76790425(-) A-G intron -    22484847 chr12:76790452(-) A-G intron -    22484847 chr12:76790754(-) A-G intron -    22484847 chr12:76790755(-) A-G intron -    22484847 chr12:76790870(-) A-G intron -    22484847 chr12:76841484(-) A-G intron -    22484847 chr12:76841528(-) A-G intron -    22484847 chr12:76841616(-) A-G intron -    22484847 chr12:76842741(-) A-G intron -    22484847 chr12:76842762(-) A-G intron -    22484847 chr12:76855407(-) G-A intron -    22484847 chr12:76876310(-) A-G intron -    22484847 chr12:76877108(-) A-G intron -    22484847 chr12:76877261(-) A-G intron -    22484847 chr12:76877727(-) A-G intron -    22484847 chr12:76878873(-) A-G intron -    22484847 chr12:76878876(-) A-G intron -    22484847 chr12:76878994(-) A-G intron -    22484847 chr12:76879149(-) A-G intron -    22484847 chr12:76879195(-) A-G intron -    22484847 chr12:76879244(-) A-G intron -    22484847 chr12:76879253(-) A-G intron -    22484847 chr12:76921932(-) A-G intron -    22484847 chr12:76922071(-) A-G intron -    22484847 chr12:76931501(-) A-G intron -    22484847 chr12:76943328(-) A-G intron -    22484847 chr12:76944826(-) A-G intron -    22484847 chr12:76947278(-) A-T intron -    22484847 chr12:76950474(-) A-G intron -    22484847 chr12:76950540(-) A-G intron -    22484847 chr12:76950549(-) A-G intron -    22484847 chr12:76950647(-) A-G intron -    22484847 chr12:76951229(-) A-G intron -    22484847 chr12:76951260(-) A-G intron -    22484847 chr12:76951273(-) A-G intron -    22484847 chr12:76951283(-) A-G intron -    22484847 chr12:76951312(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	OSBPL8	chr12:76746081-76746082(-) m6A 3'UTR       27773535 chr12:76746129-76746130(-) m6A 3'UTR       27773535 chr12:76746148-76746149(-) m6A 3'UTR       27773535 chr12:76748437-76748438(-) Y 3'UTR       26075521 chr12:76749402-76749403(-) m6A 3'UTR       27773535 chr12:76749448-76749449(-) m6A 3'UTR       24981863//27773535//22608085 chr12:76749500-76749501(-) m6A 3'UTR       24981863//27773535//22608085 chr12:76749557-76749558(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr12:76749565-76749566(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr12:76749616-76749617(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr12:76749642-76749643(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr12:76749684-76749685(-) m6A CDS       24284625//24981863//27773535//22608085 chr12:76749729-76749730(-) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr12:76750428-76750429(-) m6A CDS       24284625//24981863//27773535//22608085 chr12:76750456-76750457(-) m6A CDS       24981863//27773535//22608085 chr12:76750464-76750465(-) m6A CDS       24981863//27773535//22608085 chr12:76750494-76750495(-) m6A CDS       24981863//27773535//22608085 chr12:76752502-76752503(-) m6A CDS       24981863//27773535 chr12:76752516-76752517(-) m6A CDS       24981863//27773535 chr12:76752570-76752571(-) m6A CDS       24981863//27773535 chr12:76763008-76763009(-) m6A CDS//exon       24981863//27773535 chr12:76763019-76763020(-) m6A CDS//exon       24981863//27773535 chr12:76763066-76763067(-) m6A CDS//exon       24981863//27773535 chr12:76765250-76765251(-) m6A CDS//exon       27773535 chr12:76765333-76765334(-) m6A CDS//exon       27773535 chr12:76784208-76784209(-) m6A CDS//exon       24981863//27773535//27371828 chr12:76784223-76784224(-) m6A CDS//exon       24981863//27773535//27371828 chr12:76784237-76784238(-) m6A CDS//exon       24981863//27773535//27371828//22575960 chr12:76784265-76784266(-) m6A CDS//exon       24981863//27773535//27371828//22575960 chr12:76784286-76784287(-) m6A CDS//exon       24981863//27773535//27371828//22575960 chr12:76784352-76784353(-) m6A CDS//exon       24981863//27773535//22575960 chr12:76784398-76784399(-) m6A CDS//exon       27773535//22575960 chr12:76786429-76786430(-) Cm CDS//exon       - chr12:76796534-76796535(-) m6A CDS       - chr12:76816309-76816310(-) m6A CDS//intron       - chr12:76844755-76844756(-) m6A 5'UTR//CDS//intron       27773535 chr12:76953216-76953217(-) m6A 5'UTR//exon       27773536 chr12:76953244-76953245(-) m6A 5'UTR//exon       27773536 chr12:76953402-76953403(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27371828//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-223-5p	Exosome Primary dendritic cells     21505438 Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	OSBPL8	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-223-5p
Interactor2: OSBPL8

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.