Basic Information:

  VIRBase ID:  

HHID00065590

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-223-5p:  MIMAT0004570          MARS2:  NM_138395     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-223-5p	MARS2
miRBase Accession/Entrez ID	MIMAT0004570	92935
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	COXPD25//MetRS//mtMetRS

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-223-5p	rs1240009384 chrX:66018913    A/T rs1397275461 chrX:66018904    G/T rs1464475149 chrX:66018916    T/C rs761701581 chrX:66018906    C/G rs772305537 chrX:66018909    G/A rs774279244 chrX:66018895    C/T rs890919635 chrX:66018896    G/A

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MARS2	chr2:198570196-198570197(+) m6A CDS       24284625 chr2:198570482-198570483(+) Y CDS       26075521 chr2:198570744-198570745(+) m6A CDS       24284625//25456834//24981863//22608085 chr2:198570757-198570758(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr2:198570836-198570837(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr2:198570951-198570952(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr2:198571018-198571019(+) Y CDS       26075521 chr2:198571060-198571061(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr2:198571152-198571153(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr2:198571206-198571207(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr2:198571276-198571277(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr2:198571315-198571316(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr2:198571351-198571352(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr2:198571386-198571387(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr2:198571513-198571514(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr2:198571575-198571576(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr2:198571615-198571616(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr2:198571692-198571693(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr2:198571805-198571806(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr2:198571838-198571839(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr2:198571845-198571846(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr2:198571865-198571866(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr2:198571870-198571871(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr2:198571881-198571882(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr2:198571905-198571906(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr2:198571913-198571914(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr2:198572156-198572157(+) m6A 3'UTR       - chr2:198572198-198572199(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-223-5p	Exosome Primary dendritic cells     21505438 Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	MARS2	Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleus HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-223-5p
Interactor2: MARS2

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.