Basic Information:

  VIRBase ID:  

HHID00065588

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-223-5p:  MIMAT0004570          RASSF5:  NM_182663     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-223-5p	RASSF5
miRBase Accession/Entrez ID	MIMAT0004570	83593
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	Maxp1//NORE1//NORE1A//NORE1B//RAPL//RASSF3

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-223-5p	rs1240009384 chrX:66018913    A/T rs1397275461 chrX:66018904    G/T rs1464475149 chrX:66018916    T/C rs761701581 chrX:66018906    C/G rs772305537 chrX:66018909    G/A rs774279244 chrX:66018895    C/T rs890919635 chrX:66018896    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RASSF5	chr1:206689929(+) A-I      intronic chr1:206690551(+) A-I      intronic chr1:206690552(+) A-I      intronic chr1:206736114(+) A-I      intronic chr1:206735288(+) A-I      intronic chr1:206736118(+) A-I      intronic chr1:206735123(+) A-I      intronic chr1:206690606(+) A-I      intronic chr1:206736139(+) A-I      intronic chr1:206735098(+) A-I      intronic chr1:206735094(+) A-I      intronic chr1:206735093(+) A-I      intronic chr1:206720389(+) A-I      intronic chr1:206751560(+) A-I      intronic chr1:206736083(+) A-I      intronic chr1:206716424(+) A-I      intronic chr1:206689809(+) A-I      intronic chr1:206735270(+) A-I      intronic chr1:206715756(+) A-I      intronic chr1:206736130(+) A-I      intronic chr1:206735087(+) A-I      intronic chr1:206716465(+) A-I      intronic chr1:206716430(+) A-I      intronic chr1:206735068(+) A-I      intronic chr1:206715885(+) A-I      intronic chr1:206715819(+) A-I      intronic chr1:206751296(+) A-I      intronic chr1:206751319(+) A-I      intronic chr1:206715781(+) A-I      intronic chr1:206708402(+) A-I      intronic chr1:206748304(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	RASSF5	chr1:206715756(+) A-I intron -    15342557 chr1:206715781(+) A-I intron -    15342557 chr1:206715819(+) A-I intron -    15342557 chr1:206715885(+) A-I intron -    15342557 chr1:206716430(+) A-I intron -    15342557 chr1:206735068(+) A-G intron -    22484847 chr1:206735087(+) A-G intron -    22484847 chr1:206736130(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RASSF5	chr1:206681204-206681205(+) m6A CDS       22575960 chr1:206730494-206730495(+) m6A 5'UTR//intron       - chr1:206730590-206730591(+) m6A 5'UTR//intron       24981863//27371828 chr1:206730597-206730598(+) m6A 5'UTR//intron       24981863//27371828 chr1:206730674-206730675(+) m6A 5'UTR//intron       27371828 chr1:206730889-206730890(+) m6A 5'UTR//exon//intron       - chr1:206730911-206730912(+) m6A CDS//exon//intron       - chr1:206730951-206730952(+) m6A CDS//exon//intron       - chr1:206730959-206730960(+) m6A CDS//exon//intron       - chr1:206730979-206730980(+) m6A CDS//exon//intron       - chr1:206731008-206731009(+) m6A CDS//exon//intron       - chr1:206756611-206756612(+) m6A CDS//exon       - chr1:206756624-206756625(+) m6A CDS//exon       - chr1:206756691-206756692(+) m6A CDS//exon       - chr1:206757859-206757860(+) m6A CDS//exon       26404942 chr1:206757965-206757966(+) m6A CDS//exon       26404942 chr1:206760180-206760181(+) m6A 3'UTR//CDS//exon       22608085 chr1:206760188-206760189(+) m6A 3'UTR//CDS//exon       22608085 chr1:206760221-206760222(+) m6A 3'UTR//CDS//exon       24981863//26404942//22608085 chr1:206760267-206760268(+) m6A 3'UTR//CDS//exon       24981863//26404942//22575960//22608085 chr1:206760300-206760301(+) m6A 3'UTR//CDS//exon       24981863//26404942//22575960//22608085 chr1:206760379-206760380(+) m6A 3'UTR//exon       24284625//25456834//24981863//26404942//22575960//22608085 chr1:206760394-206760395(+) m6A 3'UTR//exon       24284625//25456834//24981863//26404942//22575960//22608085 chr1:206760460-206760461(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:206760535-206760536(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:206760546-206760547(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:206760617-206760618(+) m6A 3'UTR//exon       24209618//24981863//26404942//22575960//22608085 chr1:206760623-206760624(+) m6A 3'UTR//exon       24209618//24981863//26404942//22575960//22608085 chr1:206760725-206760726(+) m6A 3'UTR//exon       24209618//26404942//22575960//22608085 chr1:206760812-206760813(+) m6A 3'UTR//exon       24981863//26404942//22575960 chr1:206760988-206760989(+) m6A 3'UTR//exon       26404942 chr1:206761043-206761044(+) m6A 3'UTR//exon       26404942 chr1:206761161-206761162(+) m6A 3'UTR//exon       24981863//26404942 chr1:206761541-206761542(+) m6A 3'UTR//exon       26404942 chr1:206761562-206761563(+) m6A 3'UTR//exon       26404942 chr1:206761607-206761608(+) m6A 3'UTR//exon       26404942 chr1:206761658-206761659(+) m6A 3'UTR//exon       24981863//26404942//22608085 chr1:206761765-206761766(+) m6A 3'UTR//exon       24981863//26404942//22608085 chr1:206761774-206761775(+) m6A 3'UTR//exon       24981863//26404942//22608085 chr1:206761798-206761799(+) m6A 3'UTR//exon       24981863//26404942//22608085 chr1:206761847-206761848(+) m6A 3'UTR//exon       24981863//26404942 chr1:206762000-206762001(+) m6A 3'UTR//exon       24981863//26404942 chr1:206762062-206762063(+) m6A 3'UTR//exon       24981863//26404942 chr1:206762071-206762072(+) m6A 3'UTR//exon       24981863//26404942 chr1:206762122-206762123(+) m6A 3'UTR//exon       26404942 chr1:206762369-206762370(+) m6A 3'UTR//exon       26404942 chr1:206762378-206762379(+) m6A 3'UTR//exon       26404942 chr1:206762399-206762400(+) m6A 3'UTR//exon       26404942 chr1:206762424-206762425(+) m6A 3'UTR//exon       26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-223-5p	Exosome Primary dendritic cells     21505438 Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	RASSF5	Chromatin K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-223-5p
Interactor2: RASSF5

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.