Basic Information:

  VIRBase ID:  

HHID00065585

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-223-5p:  MIMAT0004570          JADE1:  NM_024900     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-223-5p	JADE1
miRBase Accession/Entrez ID	MIMAT0004570	79960
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	PHF17

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-223-5p	rs1240009384 chrX:66018913    A/T rs1397275461 chrX:66018904    G/T rs1464475149 chrX:66018916    T/C rs761701581 chrX:66018906    C/G rs772305537 chrX:66018909    G/A rs774279244 chrX:66018895    C/T rs890919635 chrX:66018896    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	JADE1	chr4:129739376(+) A-I      intronic chr4:129739375(+) A-I      intronic chr4:129734783(+) A-I      intronic chr4:129734752(+) A-I      intronic chr4:129734715(+) A-I      intronic chr4:129734713(+) A-I      intronic chr4:129754687(+) A-I      intronic chr4:129734674(+) A-I      intronic chr4:129734595(+) A-I      intronic chr4:129754699(+) A-I      intronic chr4:129754671(+) A-I      intronic chr4:129746469(+) A-I      intronic chr4:129742910(+) A-I      intronic chr4:129742749(+) A-I      intronic chr4:129772251(+) A-I      intronic chr4:129754662(+) A-I      intronic chr4:129742680(+) A-I      intronic chr4:129739380(+) A-I      intronic chr4:129754681(+) A-I      intronic chr4:129745548(+) A-I      intronic chr4:129734703(+) A-I      intronic chr4:129745489(+) A-I      intronic chr4:129745465(+) A-I      intronic chr4:129754682(+) A-I      intronic chr4:129745324(+) A-I      intronic chr4:129745318(+) A-I      intronic chr4:129743428(+) A-I      intronic chr4:129743419(+) A-I      intronic chr4:129742885(+) A-I      intronic chr4:129742714(+) A-I      intronic chr4:129742711(+) A-I      intronic chr4:129742703(+) A-I      intronic chr4:129772340(+) A-I      intronic chr4:129772322(+) A-I      intronic chr4:129772275(+) A-I      intronic chr4:129772269(+) A-I      intronic chr4:129772252(+) A-I      intronic chr4:129772190(+) A-I      intronic chr4:129772180(+) A-I      intronic chr4:129771302(+) A-I      intronic chr4:129771215(+) A-I      intronic chr4:129754672(+) A-I      intronic chr4:129747630(+) A-I      intronic chr4:129747593(+) A-I      intronic chr4:129746294(+) A-I      intronic chr4:129754770(+) A-I      intronic chr4:129771293(+) A-I      intronic chr4:129747582(+) A-I      intronic chr4:129751150(+) A-I      intronic chr4:129755952(+) A-I      intronic chr4:129771334(+) A-I      intronic chr4:129746396(+) A-I      intronic chr4:129771342(+) A-I      intronic chr4:129747543(+) A-I      intronic chr4:129772288(+) A-I      intronic chr4:129747613(+) A-I      intronic chr4:129742815(+) A-I      intronic chr4:129771185(+) A-I      intronic chr4:129754649(+) A-I      intronic chr4:129738456(+) A-I      intronic chr4:129754751(+) A-I      intronic chr4:129754738(+) A-I      intronic chr4:129743612(+) A-I      intronic chr4:129745487(+) A-I      intronic chr4:129742817(+) A-I      intronic chr4:129755807(+) A-I      intronic chr4:129747836(+) A-I      intronic chr4:129771338(+) A-I      intronic chr4:129745577(+) A-I      intronic chr4:129754729(+) A-I      intronic chr4:129751133(+) A-I      intronic chr4:129755818(+) A-I      intronic chr4:129746256(+) A-I      intronic chr4:129771247(+) A-I      intronic chr4:129743509(+) A-I      intronic chr4:129746430(+) A-I      intronic chr4:129772211(+) A-I      intronic chr4:129746218(+) A-I      intronic chr4:129771450(+) A-I      intronic chr4:129755896(+) A-I      intronic chr4:129745520(+) A-I      intronic chr4:129754642(+) A-I      intronic chr4:129771291(+) A-I      intronic chr4:129740030(+) A-I      intronic chr4:129743719(+) A-I      intronic chr4:129746229(+) A-I      intronic chr4:129747652(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	JADE1	chr4:129730877-129730878(+) m6A 5'UTR       24209618//24981863 chr4:129730965-129730966(+) m6A 5'UTR       24209618 chr4:129733015-129733016(+) m6A 5'UTR//intron       24981863 chr4:129783300-129783301(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr4:129783369-129783370(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr4:129783482-129783483(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr4:129783541-129783542(+) m6A 3'UTR//intron       24284625//24209618//24981863//22608085 chr4:129783563-129783564(+) m6A 3'UTR//intron       24284625//24209618//24981863//22608085 chr4:129783610-129783611(+) m6A 3'UTR//intron       24284625//24981863 chr4:129783747-129783748(+) m6A 3'UTR//intron       25456834//24981863 chr4:129783760-129783761(+) m6A 3'UTR//intron       25456834//24981863 chr4:129784560-129784561(+) m6A 3'UTR//intron       - chr4:129784575-129784576(+) m6A 3'UTR//intron       - chr4:129784584-129784585(+) m6A 3'UTR//intron       - chr4:129784591-129784592(+) m6A 3'UTR//intron       - chr4:129784616-129784617(+) m6A 3'UTR//intron       - chr4:129784845-129784846(+) m6A 3'UTR//intron       - chr4:129784916-129784917(+) m6A 3'UTR//intron       - chr4:129785733-129785734(+) m6A 3'UTR//intron       24981863 chr4:129785769-129785770(+) m6A 3'UTR//intron       24981863 chr4:129789017-129789018(+) m6A CDS       24981863 chr4:129789078-129789079(+) m6A CDS       24284625//24209618//24981863 chr4:129792545-129792546(+) m6A CDS       24284625//24209618//24981863//22608085 chr4:129792599-129792600(+) m6A CDS       24284625//25456834//24981863//22608085 chr4:129792630-129792631(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr4:129792715-129792716(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr4:129792734-129792735(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr4:129792793-129792794(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr4:129792851-129792852(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr4:129792869-129792870(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr4:129792902-129792903(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr4:129792911-129792912(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr4:129792924-129792925(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr4:129792974-129792975(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr4:129793073-129793074(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr4:129793084-129793085(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr4:129793127-129793128(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr4:129793211-129793212(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr4:129793381-129793382(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr4:129793499-129793500(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr4:129793523-129793524(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr4:129793617-129793618(+) m6A 3'UTR       24981863//22608085 chr4:129793643-129793644(+) m6A 3'UTR       24981863//22608085 chr4:129793654-129793655(+) m6A 3'UTR       24981863//26404942//22608085 chr4:129793660-129793661(+) m6A 3'UTR       24981863//26404942//22608085 chr4:129793666-129793667(+) m6A 3'UTR       24981863//26404942//22608085 chr4:129793671-129793672(+) m6A 3'UTR       24981863//26404942//22608085 chr4:129793764-129793765(+) m6A 3'UTR       24981863//26404942 chr4:129793789-129793790(+) m6A 3'UTR       24981863 chr4:129794027-129794028(+) m6A 3'UTR       24981863 chr4:129794311-129794312(+) m6A 3'UTR       27773535 chr4:129794319-129794320(+) m6A 3'UTR       27773535 chr4:129794493-129794494(+) m6A 3'UTR       24981863//27773535//22608085 chr4:129794556-129794557(+) m6A 3'UTR       24981863//27773535//22608085 chr4:129794601-129794602(+) m6A 3'UTR       24981863 chr4:129795625-129795626(+) m6A 3'UTR       27773535 chr4:129795635-129795636(+) m6A 3'UTR       27773535 chr4:129795640-129795641(+) m6A 3'UTR       27773535 chr4:129795646-129795647(+) m6A 3'UTR       27773535 chr4:129795651-129795652(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-223-5p	Exosome Primary dendritic cells     21505438 Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	JADE1	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-223-5p
Interactor2: JADE1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.