Detail Information

Basic Information:


  VIRBase ID:  

HHID00065582

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-223-5p:           PLEKHF2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-223-5p PLEKHF2
miRBase
Accession/Entrez ID		 MIMAT0004570 79666
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - EAPF//PHAFIN2//ZFYVE18

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-223-5p
rs1240009384 chrX:66018913    A/T
rs1397275461 chrX:66018904    G/T
rs1464475149 chrX:66018916    T/C
rs761701581 chrX:66018906    C/G
rs772305537 chrX:66018909    G/A
rs774279244 chrX:66018895    C/T
rs890919635 chrX:66018896    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PLEKHF2
chr8:96157024(+) A-I      intronic
chr8:96156821(+) A-I      intronic
chr8:96157726(+) A-I      intronic
chr8:96154717(+) A-I      intronic
chr8:96157732(+) A-I      intronic
chr8:96157120(+) A-I      intronic
chr8:96157721(+) A-I      intronic
chr8:96167873(+) A-I      3'UTR
chr8:96157012(+) A-I      intronic
chr8:96154718(+) A-I      intronic
chr8:96156974(+) A-I      intronic
chr8:96151667(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED PLEKHF2
chr8:96156975(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PLEKHF2
chr8:96146137-96146138(+) m6A 5'UTR       24981863
chr8:96146212-96146213(+) m6A 5'UTR       24209618//24981863//22608085
chr8:96146319-96146320(+) m6A 5'UTR//intron       22608085
chr8:96166291-96166292(+) m6A CDS       24284625//24209618//24981863//22575960//22608085
chr8:96166330-96166331(+) m6A CDS       24284625//24209618//24981863//22575960//22608085
chr8:96166499-96166500(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:96166555-96166556(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr8:96166581-96166582(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr8:96166689-96166690(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:96166703-96166704(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:96166915-96166916(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:96166945-96166946(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:96167024-96167025(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:96167137-96167138(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-223-5p
Exosome Primary dendritic cells     21505438
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
PLEKHF2
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleoplasm K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-223-5p
Interactor2: PLEKHF2

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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