Detail Information

Basic Information:


  VIRBase ID:  

HHID00065579

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-223-5p:           RMND5A:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-223-5p RMND5A
miRBase
Accession/Entrez ID		 MIMAT0004570 64795
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CTLH//GID2//GID2A//p44CTLH//RMD5

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-223-5p
rs1240009384 chrX:66018913    A/T
rs1397275461 chrX:66018904    G/T
rs1464475149 chrX:66018916    T/C
rs761701581 chrX:66018906    C/G
rs772305537 chrX:66018909    G/A
rs774279244 chrX:66018895    C/T
rs890919635 chrX:66018896    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR RMND5A
chr2:86993699(+) A-I      intronic
chr2:86993736(+) A-I      intronic
chr2:86993683(+) A-I      intronic
chr2:86982371(+) A-I      intronic
chr2:86982463(+) A-I      intronic
chr2:86982510(+) A-I      intronic
chr2:86983331(+) A-I      intronic
chr2:86983333(+) A-I      intronic
chr2:86983377(+) A-I      intronic
chr2:86983401(+) A-I      intronic
chr2:86986764(+) A-I      intronic
chr2:86986832(+) A-I      intronic
chr2:86987224(+) A-I      intronic
chr2:86981844(+) A-I      intronic
chr2:86993684(+) A-I      intronic
chr2:86993672(+) A-I      intronic
chr2:86993625(+) A-I      intronic
chr2:86993693(+) A-I      intronic
chr2:86993539(+) A-I      intronic
chr2:86990701(+) A-I      intronic
chr2:86990693(+) A-I      intronic
chr2:86990097(+) A-I      intronic
chr2:86987267(+) A-I      intronic
chr2:86993695(+) A-I      intronic
chr2:86993810(+) A-I      intronic
chr2:86996190(+) A-I      intronic
chr2:86987367(+) A-I      intronic
chr2:86987325(+) A-I      intronic
chr2:86999754(+) A-I      intronic
chr2:86999857(+) A-I      intronic
chr2:86987268(+) A-I      intronic
chr2:86981893(+) A-I      intronic
chr2:86982345(+) A-I      intronic
chr2:86987231(+) A-I      intronic
chr2:86981881(+) A-I      intronic
chr2:86986843(+) A-I      intronic
chr2:86996330(+) A-I      intronic
chr2:86993547(+) A-I      intronic
chr2:86984095(+) A-I      intronic
chr2:86986864(+) A-I      intronic
chr2:86996130(+) A-I      intronic
chr2:86983387(+) A-I      intronic
chr2:86994478(+) A-I      intronic
chr2:86993569(+) A-I      intronic
chr2:86999449(+) A-I      intronic
chr2:86996178(+) A-I      intronic
chr2:86987285(+) A-I      intronic
chr2:86987313(+) A-I      intronic
chr2:86999859(+) A-I      intronic
chr2:86990052(+) A-I      intronic
chr2:86981738(+) A-I      intronic
chr2:86999787(+) A-I      intronic
chr2:86993676(+) A-I      intronic
chr2:86999847(+) A-I      intronic
chr2:86983395(+) A-I      intronic
chr2:86982309(+) A-I      intronic
chr2:86999457(+) A-I      intronic
chr2:86981976(+) A-I      intronic
chr2:86970618(+) A-I      intronic
chr2:86987347(+) A-I      intronic
chr2:86986762(+) A-I      intronic
chr2:86987387(+) A-I      intronic
chr2:86989647(+) A-I      intronic
chr2:86986759(+) A-I      intronic
chr2:86994447(+) A-I      intronic
chr2:86993646(+) A-I      intronic
chr2:86986878(+) A-I      intronic
chr2:86993605(+) A-I      intronic
chr2:86982462(+) A-I      intronic
chr2:86993737(+) A-I      intronic
chr2:86999907(+) A-I      intronic
chr2:86986838(+) A-I      intronic
chr2:86993621(+) A-I      intronic
chr2:86987395(+) A-I      intronic
chr2:86984110(+) A-I      intronic
chr2:86984247(+) A-I      intronic
chr2:86987245(+) A-I      intronic
chr2:86993640(+) A-I      intronic
chr2:86982381(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED RMND5A
chr2:86970618(+) A-G intron -    22484847
chr2:86982309(+) A-G intron -    22484847
chr2:86982462(+) A-G intron -    22484847
chr2:86986759(+) A-G intron -    22484847
chr2:86986762(+) A-G intron -    22484847
chr2:86986838(+) A-G intron -    22484847
chr2:86986843(+) A-G intron -    22484847
chr2:86986878(+) A-G intron -    22484847
chr2:86987245(+) A-G intron -    22484847
chr2:86987285(+) A-G intron -    22484847
chr2:86987313(+) A-G intron -    22484847
chr2:86987323(+) A-G intron -    22484847
chr2:86990060(+) A-G intron -    22484847
chr2:86993547(+) A-G intron -    22484847
chr2:86993667(+) A-G intron -    22484847
chr2:86996130(+) A-G intron -    22484847
chr2:86996178(+) A-G intron -    22484847
chr2:86999449(+) A-G intron -    22484847
chr2:86999457(+) A-G intron -    22484847
chr2:86999787(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase RMND5A
chr2:86947451-86947452(+) m6A 5'UTR       24981863
chr2:86947479-86947480(+) m6A 5'UTR       24981863
chr2:86947485-86947486(+) m6A 5'UTR       24981863
chr2:86968072-86968073(+) m6A CDS       -
chr2:86998749-86998750(+) m6A CDS//exon       24284625
chr2:87000497-87000498(+) m6A CDS//exon       24284625//24981863//26404942//22608085
chr2:87000518-87000519(+) m6A CDS//exon       24284625//24981863//26404942//22608085
chr2:87000567-87000568(+) m6A 3'UTR//exon       24284625//24981863//26404942//22575960//22608085
chr2:87000624-87000625(+) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr2:87000657-87000658(+) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//22575960//22608085
chr2:87001736-87001737(+) m6A 3'UTR       24284625//24981863//27773535//22608085
chr2:87001750-87001751(+) m6A 3'UTR       24284625//24981863//27773535//22608085
chr2:87001760-87001761(+) m6A 3'UTR       24284625//24981863//27773535//22608085
chr2:87001777-87001778(+) m6A 3'UTR       24284625//24981863//27773535//22608085
chr2:87001863-87001864(+) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085
chr2:87001896-87001897(+) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085
chr2:87001935-87001936(+) m6A 3'UTR       24284625//25456834//24981863//26404942//27773535//22575960//22608085
chr2:87001946-87001947(+) m6A 3'UTR       24284625//25456834//24981863//26404942//27773535//22575960//22608085
chr2:87001997-87001998(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr2:87002100-87002101(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chr2:87002312-87002313(+) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085
chr2:87002318-87002319(+) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085
chr2:87002331-87002332(+) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085
chr2:87002384-87002385(+) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085
chr2:87002422-87002423(+) m6A 3'UTR       24284625//25456834//24981863//22608085
chr2:87002891-87002892(+) m6A 3'UTR       26404942
chr2:87002909-87002910(+) m6A 3'UTR       26404942
chr2:87002946-87002947(+) m6A 3'UTR       26404942
chr2:87002997-87002998(+) m6A 3'UTR       26404942
chr2:87004884-87004885(+) m6A 3'UTR       27773535
chr2:87004910-87004911(+) m6A 3'UTR       27773535
chr2:87004926-87004927(+) m6A 3'UTR       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-223-5p
Exosome Primary dendritic cells     21505438
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
RMND5A
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-223-5p
Interactor2: RMND5A

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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