Detail Information

Basic Information:


  VIRBase ID:  

HHID00065578

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-223-5p:           IFIH1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-223-5p IFIH1
miRBase
Accession/Entrez ID		 MIMAT0004570 64135
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - AGS7//Hlcd//IDDM19//MDA-5//MDA5//RLR-2//SGMRT1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-223-5p
rs1240009384 chrX:66018913    A/T
rs1397275461 chrX:66018904    G/T
rs1464475149 chrX:66018916    T/C
rs761701581 chrX:66018906    C/G
rs772305537 chrX:66018909    G/A
rs774279244 chrX:66018895    C/T
rs890919635 chrX:66018896    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR IFIH1
chr2:163159714(-) A-I      intronic
chr2:163159746(-) A-I      intronic
chr2:163159710(-) A-I      intronic
chr2:163159716(-) A-I      intronic
chr2:163159721(-) A-I      intronic
chr2:163159773(-) A-I      intronic
chr2:163159905(-) A-I      intronic
chr2:163161968(-) A-I      intronic
chr2:163165017(-) A-I      intronic
chr2:163161817(-) A-I      intronic
chr2:163125269(-) A-I      intronic
chr2:163165004(-) A-I      intronic
chr2:163161917(-) A-I      intronic
chr2:163161998(-) A-I      intronic
chr2:163159814(-) A-I      intronic
chr2:163165011(-) A-I      intronic
chr2:163161823(-) A-I      intronic
chr2:163161997(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED IFIH1
chr2:163132849(-) C-G intron -    22484847
chr2:163161917(-) A-G intron -    22484847
chr2:163161997(-) A-G intron -    22484847
chr2:163161998(-) A-G intron -    22484847
chr2:163165011(-) A-G intron -    22484847
chr2:163165017(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase IFIH1
chr2:163133357-163133358(-) m6A CDS       27773535
chr2:163133422-163133423(-) m6A CDS       27773535
chr2:163133452-163133453(-) m6A CDS       27773535
chr2:163133954-163133955(-) m6A CDS       27773535
chr2:163133964-163133965(-) m6A CDS       27773535
chr2:163133973-163133974(-) m6A CDS       27773535
chr2:163134086-163134087(-) m6A CDS       24981863//27773535
chr2:163134162-163134163(-) m6A CDS       24981863
chr2:163134742-163134743(-) m6A CDS       24981863
chr2:163150122-163150123(-) m6A CDS//exon       27773535
chr2:163150171-163150172(-) m6A CDS//exon       27773535
chr2:163166688-163166689(-) m6A 3'UTR//intron       27773535
chr2:163166751-163166752(-) m6A 3'UTR//intron       27773535
chr2:163166824-163166825(-) m6A 3'UTR//intron       27773535
chr2:163166916-163166917(-) m6A 3'UTR//intron       27773535
chr2:163167027-163167028(-) m6A 3'UTR//intron       27773535
chr2:163167074-163167075(-) m6A 3'UTR//intron       24981863//27773535
chr2:163167153-163167154(-) m6A 3'UTR//intron       24981863//27773535
chr2:163167190-163167191(-) m6A 3'UTR//intron       24981863//27773535
chr2:163167202-163167203(-) m6A 3'UTR//intron       24981863//27773535
chr2:163167320-163167321(-) m6A CDS       24981863//27773535//27371828//22575960
chr2:163167327-163167328(-) m6A CDS       24981863//27773535//27371828//22575960
chr2:163167334-163167335(-) m6A CDS       24981863//28052920//27773535//27371828//22575960
chr2:163167369-163167370(-) m6A CDS       24981863//28052920//27773535//27371828//22575960
chr2:163167426-163167427(-) m6A CDS       24981863//28052920//27773535//27371828//22575960
chr2:163174368-163174369(-) m6A CDS       24981863//28052920//27773535//27371828//22575960
chr2:163174374-163174375(-) m6A CDS       24981863//28052920//27773535//27371828//22575960
chr2:163174391-163174392(-) m6A CDS       24981863//28052920//27773535//27371828//22575960
chr2:163174437-163174438(-) m6A CDS       24981863//28052920//27773535//27371828//22575960
chr2:163174461-163174462(-) m6A CDS       24981863//28052920//27773535//27371828//22575960
chr2:163174515-163174516(-) m6A CDS       25456834//24981863//28052920//27773535//27371828//22575960
chr2:163174530-163174531(-) m6A CDS       25456834//24981863//28052920//27773535//27371828//22575960
chr2:163174561-163174562(-) m6A CDS       24209618//25456834//24981863//28052920//27773535//27371828//22575960
chr2:163174591-163174592(-) m6A CDS       24209618//25456834//24981863//28052920//27773535//27371828//22575960
chr2:163174637-163174638(-) m6A CDS       24209618//25456834//24981863//28052920//27773535//27371828//22575960
chr2:163174653-163174654(-) m6A CDS       24209618//25456834//24981863//28052920//27773535//27371828//22575960
chr2:163174672-163174673(-) m6A CDS       24209618//25456834//24981863//28052920//27773535//27371828//22575960
chr2:163174719-163174720(-) m6A CDS       25456834//24981863//28052920//27773535//27371828//22575960
chr2:163174959-163174960(-) m6A 5'UTR       27371828
chr2:163175112-163175113(-) m6A 5'UTR       24209618//27371828
chr2:163175159-163175160(-) m6A 5'UTR       24209618//27371828
chr2:163175179-163175180(-) m6A 5'UTR       24209618//27371828
chr2:163175190-163175191(-) m6A 5'UTR       27371828
chr2:163175205-163175206(-) m6A 5'UTR       27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-223-5p
Exosome Primary dendritic cells     21505438
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
IFIH1
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-223-5p
Interactor2: IFIH1

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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