Detail Information

Basic Information:


  VIRBase ID:  

HHID00065576

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-223-5p:           RAP2C:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-223-5p RAP2C
miRBase
Accession/Entrez ID		 MIMAT0004570 57826
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - -

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-223-5p
rs1240009384 chrX:66018913    A/T
rs1397275461 chrX:66018904    G/T
rs1464475149 chrX:66018916    T/C
rs761701581 chrX:66018906    C/G
rs772305537 chrX:66018909    G/A
rs774279244 chrX:66018895    C/T
rs890919635 chrX:66018896    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR RAP2C
chrX:131342288(-) A-I      intronic
chrX:131344490(-) A-I      intronic
chrX:131344485(-) A-I      intronic
chrX:131344484(-) A-I      intronic
chrX:131342168(-) A-I      intronic
chrX:131344499(-) A-I      intronic
chrX:131344548(-) A-I      intronic
chrX:131344551(-) A-I      intronic
chrX:131344464(-) A-I      intronic
chrX:131342240(-) A-I      intronic
chrX:131342229(-) A-I      intronic
chrX:131342219(-) A-I      intronic
chrX:131342200(-) A-I      intronic
chrX:131342170(-) A-I      intronic
chrX:131342197(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED RAP2C
chrX:131344650(-) A-I intron -    22327324
chrX:131344608(-) A-I intron -    21960545

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase RAP2C
chrX:131339456-131339457(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085
chrX:131339536-131339537(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//27773535//22575960//22608085
chrX:131339551-131339552(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085
chrX:131339573-131339574(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chrX:131339609-131339610(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chrX:131348253-131348254(-) m6A CDS//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chrX:131348282-131348283(-) m6A CDS//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chrX:131348314-131348315(-) m6A CDS//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22608085
chrX:131348384-131348385(-) m6A CDS//exon       24284625//24981863//27371828//22608085
chrX:131351115-131351116(-) m6A 5'UTR//CDS//exon       24284625//24981863//27371828//22575960//22608085
chrX:131351126-131351127(-) m6A 5'UTR//CDS//exon       24284625//24981863//27371828//22575960//22608085
chrX:131351156-131351157(-) m6A 5'UTR//CDS//exon       24284625//24981863//27773535//27371828//22575960//22608085
chrX:131351217-131351218(-) m6A CDS//intron       24284625//24981863//27773535//27371828//22575960//22608085
chrX:131351299-131351300(-) m6A 5'UTR//intron       24284625//24981863//27773535//22608085
chrX:131351612-131351613(-) Y 5'UTR//intron       26075521
chrX:131351799-131351800(-) m6A 5'UTR//exon//intron       27371828//27773536
chrX:131352018-131352019(-) m6A 5'UTR//intron       24209618//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-223-5p
Exosome Primary dendritic cells     21505438
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
RAP2C
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-223-5p
Interactor2: RAP2C

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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