Basic Information:

  VIRBase ID:  

HHID00065574

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-223-5p:  MIMAT0004570          MIB1:  NM_020774     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-223-5p	MIB1
miRBase Accession/Entrez ID	MIMAT0004570	57534
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	DIP-1//DIP1//LVNC7//MIB//ZZANK2//ZZZ6

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-223-5p	rs1240009384 chrX:66018913    A/T rs1397275461 chrX:66018904    G/T rs1464475149 chrX:66018916    T/C rs761701581 chrX:66018906    C/G rs772305537 chrX:66018909    G/A rs774279244 chrX:66018895    C/T rs890919635 chrX:66018896    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MIB1	chr18:19330943(+) A-I      intronic chr18:19330948(+) A-I      intronic chr18:19330957(+) A-I      intronic chr18:19330972(+) A-I      intronic chr18:19330993(+) A-I      intronic chr18:19387270(+) A-I      intronic chr18:19387282(+) A-I      intronic chr18:19385964(+) A-I      intronic chr18:19387313(+) A-I      intronic chr18:19394429(+) A-I      intronic chr18:19440889(+) A-I      intronic chr18:19440945(+) A-I      intronic chr18:19419569(+) A-I      intronic chr18:19387289(+) A-I      intronic chr18:19331008(+) A-I      intronic chr18:19330982(+) A-I      intronic chr18:19330981(+) A-I      intronic chr18:19330925(+) A-I      intronic chr18:19330351(+) A-I      intronic chr18:19329846(+) A-I      intronic chr18:19329701(+) A-I      intronic chr18:19441975(+) A-I      intronic chr18:19441930(+) A-I      intronic chr18:19441927(+) A-I      intronic chr18:19440942(+) A-I      intronic chr18:19440926(+) A-I      intronic chr18:19439756(+) A-I      intronic chr18:19439707(+) A-I      intronic chr18:19439703(+) A-I      intronic chr18:19439689(+) A-I      intronic chr18:19439685(+) A-I      intronic chr18:19439674(+) A-I      intronic chr18:19421959(+) A-I      intronic chr18:19421958(+) A-I      intronic chr18:19421256(+) A-I      intronic chr18:19421253(+) A-I      intronic chr18:19421221(+) A-I      intronic chr18:19419919(+) A-I      intronic chr18:19419596(+) A-I      intronic chr18:19419585(+) A-I      intronic chr18:19419530(+) A-I      intronic chr18:19419527(+) A-I      intronic chr18:19416209(+) A-I      intronic chr18:19416208(+) A-I      intronic chr18:19416201(+) A-I      intronic chr18:19416199(+) A-I      intronic chr18:19416198(+) A-I      intronic chr18:19416150(+) A-I      intronic chr18:19399262(+) A-I      intronic chr18:19399261(+) A-I      intronic chr18:19399183(+) A-I      intronic chr18:19399099(+) A-I      intronic chr18:19398802(+) A-I      intronic chr18:19398625(+) A-I      intronic chr18:19398515(+) A-I      intronic chr18:19394464(+) A-I      intronic chr18:19387272(+) A-I      intronic chr18:19387239(+) A-I      intronic chr18:19387236(+) A-I      intronic chr18:19387231(+) A-I      intronic chr18:19387227(+) A-I      intronic chr18:19387191(+) A-I      intronic chr18:19331358(+) A-I      intronic chr18:19387142(+) A-I      intronic chr18:19387136(+) A-I      intronic chr18:19386751(+) A-I      intronic chr18:19386262(+) A-I      intronic chr18:19386261(+) A-I      intronic chr18:19369592(+) A-I      intronic chr18:19369591(+) A-I      intronic chr18:19357728(+) A-I      intronic chr18:19357358(+) A-I      intronic chr18:19357274(+) A-I      intronic chr18:19357259(+) A-I      intronic chr18:19356903(+) A-I      intronic chr18:19356888(+) A-I      intronic chr18:19356883(+) A-I      intronic chr18:19356779(+) A-I      intronic chr18:19355996(+) A-I      intronic chr18:19421231(+) A-I      intronic chr18:19355994(+) A-I      intronic chr18:19355439(+) A-I      intronic chr18:19355438(+) A-I      intronic chr18:19355389(+) A-I      intronic chr18:19355342(+) A-I      intronic chr18:19355306(+) A-I      intronic chr18:19355275(+) A-I      intronic chr18:19355245(+) A-I      intronic chr18:19355167(+) A-I      intronic chr18:19355149(+) A-I      intronic chr18:19354545(+) A-I      intronic chr18:19354507(+) A-I      intronic chr18:19354498(+) A-I      intronic chr18:19354364(+) A-I      intronic chr18:19343937(+) A-I      intronic chr18:19337669(+) A-I      intronic chr18:19337668(+) A-I      intronic chr18:19337644(+) A-I      intronic chr18:19336645(+) A-I      intronic chr18:19333660(+) A-I      intronic chr18:19331419(+) A-I      intronic chr18:19331405(+) A-I      intronic chr18:19331118(+) A-I      intronic chr18:19331069(+) A-I      intronic chr18:19331044(+) A-I      intronic chr18:19440879(+) A-I      intronic chr18:19398643(+) A-I      intronic chr18:19399209(+) A-I      intronic chr18:19356827(+) A-I      intronic chr18:19355088(+) A-I      intronic chr18:19337260(+) A-I      intronic chr18:19439594(+) A-I      intronic chr18:19354429(+) A-I      intronic chr18:19440336(+) A-I      intronic chr18:19331407(+) A-I      intronic chr18:19419698(+) A-I      intronic chr18:19331409(+) A-I      intronic chr18:19399049(+) A-I      intronic chr18:19357655(+) A-I      intronic chr18:19387213(+) A-I      intronic chr18:19399200(+) A-I      intronic chr18:19328581(+) A-I      intronic chr18:19387230(+) A-I      intronic chr18:19385074(+) A-I      intronic chr18:19357538(+) A-I      intronic chr18:19387190(+) A-I      intronic chr18:19357266(+) A-I      intronic chr18:19355319(+) A-I      intronic chr18:19331048(+) A-I      intronic chr18:19441906(+) A-I      intronic chr18:19439770(+) A-I      intronic chr18:19337212(+) A-I      intronic chr18:19416104(+) A-I      intronic chr18:19357699(+) A-I      intronic chr18:19355405(+) A-I      intronic chr18:19386726(+) A-I      intronic chr18:19357616(+) A-I      intronic chr18:19398566(+) A-I      intronic chr18:19387234(+) A-I      intronic chr18:19440245(+) A-I      intronic chr18:19399198(+) A-I      intronic chr18:19331038(+) A-I      intronic chr18:19356243(+) A-I      intronic chr18:19386347(+) A-I      intronic chr18:19355313(+) A-I      intronic chr18:19441989(+) A-I      intronic chr18:19330933(+) A-I      intronic chr18:19357306(+) A-I      intronic chr18:19416270(+) A-I      intronic chr18:19386117(+) A-I      intronic chr18:19355113(+) A-I      intronic chr18:19394615(+) A-I      intronic chr18:19357202(+) A-I      intronic chr18:19354532(+) A-I      intronic chr18:19330903(+) A-I      intronic chr18:19394604(+) A-I      intronic chr18:19386640(+) A-I      intronic chr18:19394421(+) A-I      intronic chr18:19394680(+) A-I      intronic chr18:19386781(+) A-I      intronic chr18:19421248(+) A-I      intronic chr18:19354294(+) A-I      intronic chr18:19354512(+) A-I      intronic chr18:19357194(+) A-I      intronic chr18:19354434(+) A-I      intronic chr18:19398817(+) A-I      intronic chr18:19357233(+) A-I      intronic chr18:19387193(+) A-I      intronic chr18:19330884(+) A-I      intronic chr18:19398776(+) A-I      intronic chr18:19337661(+) A-I      intronic chr18:19330699(+) A-I      intronic chr18:19330487(+) A-I      intronic chr18:19394447(+) A-I      intronic chr18:19336555(+) A-I      intronic chr18:19398781(+) A-I      intronic chr18:19419589(+) A-I      intronic chr18:19355966(+) A-I      intronic chr18:19398555(+) A-I      intronic chr18:19361492(+) A-I      intronic chr18:19357596(+) A-I      intronic chr18:19440975(+) A-I      intronic chr18:19440906(+) A-I      intronic chr18:19355383(+) A-I      intronic chr18:19331348(+) A-I      intronic chr18:19441963(+) A-I      intronic chr18:19355973(+) A-I      intronic chr18:19337236(+) A-I      intronic chr18:19387137(+) A-I      intronic chr18:19354385(+) A-I      intronic chr18:19399132(+) A-I      intronic chr18:19329626(+) A-I      intronic chr18:19440126(+) A-I      intronic chr18:19337667(+) A-I      intronic chr18:19394469(+) A-I      intronic chr18:19443846(+) A-I      intronic chr18:19387318(+) A-I      intronic chr18:19398564(+) A-I      intronic chr18:19386766(+) A-I      intronic chr18:19330589(+) A-I      intronic chr18:19439242(+) A-I      intronic chr18:19357634(+) A-I      intronic chr18:19354366(+) A-I      intronic chr18:19387389(+) A-I      intronic chr18:19386789(+) A-I      intronic chr18:19386856(+) A-I      intronic chr18:19329702(+) A-I      intronic chr18:19386383(+) A-I      intronic chr18:19419497(+) A-I      intronic chr18:19394527(+) A-I      intronic chr18:19441966(+) A-I      intronic chr18:19419519(+) A-I      intronic chr18:19419684(+) A-I      intronic chr18:19394477(+) A-I      intronic chr18:19357293(+) A-I      intronic chr18:19330902(+) A-I      intronic chr18:19421982(+) A-I      intronic chr18:19354388(+) A-I      intronic chr18:19330919(+) A-I      intronic chr18:19357615(+) A-I      intronic chr18:19346761(+) A-I      intronic chr18:19354398(+) A-I      intronic chr18:19419559(+) A-I      intronic chr18:19395210(+) A-I      intronic chr18:19337709(+) A-I      intronic chr18:19350009(+) A-I      intronic chr18:19337254(+) A-I      intronic chr18:19394405(+) A-I      intronic chr18:19331340(+) A-I      intronic chr18:19355465(+) A-I      intronic chr18:19355334(+) A-I      intronic chr18:19443750(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MIB1	chr18:19405668(+) A-I intron -    16594986 chr18:19331012(+) A-G intron -    22484847 chr18:19336526(+) A-G intron -    22484847 chr18:19357716(+) A-G intron -    22484847 chr18:19361603(+) T-A intron -    22484847 chr18:19387318(+) A-G intron -    22484847 chr18:19421976(+) A-G intron -    22484847 chr18:19421982(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MIB1	chr18:19321383-19321384(+) m6A 5'UTR//intron       24209618 chr18:19321611-19321612(+) m6A CDS//intron       24209618//25456834//24981863//22608085 chr18:19321701-19321702(+) m6A CDS//intron       24209618//25456834//24981863//22575960//22608085 chr18:19321758-19321759(+) m6A CDS//intron       24209618//25456834//24981863//22575960//22608085 chr18:19345749-19345750(+) m6A CDS//exon       22608085 chr18:19348666-19348667(+) m6A CDS//exon       24209618//24981863 chr18:19353600-19353601(+) m6A CDS//exon       24209618//24981863 chr18:19445264-19445265(+) m6A 3'UTR       24981863 chr18:19445311-19445312(+) m6A 3'UTR       24981863 chr18:19447867-19447868(+) m6A 3'UTR       24981863 chr18:19450245-19450246(+) Y 3'UTR       26075521

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-223-5p	Exosome Primary dendritic cells     21505438 Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	MIB1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-223-5p
Interactor2: MIB1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.