Basic Information:

  VIRBase ID:  

HHID00065572

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-223-5p:  MIMAT0004570          TWSG1:  NM_020648     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-223-5p	TWSG1
miRBase Accession/Entrez ID	MIMAT0004570	57045
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	TSG

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-223-5p	rs1240009384 chrX:66018913    A/T rs1397275461 chrX:66018904    G/T rs1464475149 chrX:66018916    T/C rs761701581 chrX:66018906    C/G rs772305537 chrX:66018909    G/A rs774279244 chrX:66018895    C/T rs890919635 chrX:66018896    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TWSG1	chr18:9370132(+) A-I      intronic chr18:9369501(+) A-I      intronic chr18:9369487(+) A-I      intronic chr18:9365123(+) A-I      intronic chr18:9365118(+) A-I      intronic chr18:9367207(+) A-I      intronic chr18:9376703(+) A-I      intronic chr18:9398878(+) A-I      intronic chr18:9369086(+) A-I      intronic chr18:9370023(+) A-I      intronic chr18:9369061(+) A-I      intronic chr18:9365117(+) A-I      intronic chr18:9376719(+) A-I      intronic chr18:9386297(+) A-I      intronic chr18:9364527(+) A-I      intronic chr18:9364590(+) A-I      intronic chr18:9386302(+) A-I      intronic chr18:9364627(+) A-I      intronic chr18:9365138(+) A-I      intronic chr18:9365137(+) A-I      intronic chr18:9369544(+) A-I      intronic chr18:9370063(+) A-I      intronic chr18:9371554(+) A-I      intronic chr18:9373447(+) A-I      intronic chr18:9393698(+) A-I      intronic chr18:9386307(+) A-I      intronic chr18:9386300(+) A-I      intronic chr18:9386311(+) A-I      intronic chr18:9398864(+) A-I      intronic chr18:9376668(+) A-I      intronic chr18:9370166(+) A-I      intronic chr18:9370163(+) A-I      intronic chr18:9370158(+) A-I      intronic chr18:9398666(+) A-I      intronic chr18:9398646(+) A-I      intronic chr18:9398597(+) A-I      intronic chr18:9398595(+) A-I      intronic chr18:9398585(+) A-I      intronic chr18:9398556(+) A-I      intronic chr18:9398555(+) A-I      intronic chr18:9398486(+) A-I      intronic chr18:9398474(+) A-I      intronic chr18:9397818(+) A-I      intronic chr18:9397817(+) A-I      intronic chr18:9397814(+) A-I      intronic chr18:9397013(+) A-I      intronic chr18:9397011(+) A-I      intronic chr18:9378783(+) A-I      intronic chr18:9396962(+) A-I      intronic chr18:9395732(+) A-I      intronic chr18:9393619(+) A-I      intronic chr18:9390982(+) A-I      intronic chr18:9390884(+) A-I      intronic chr18:9390566(+) A-I      intronic chr18:9388993(+) A-I      intronic chr18:9387548(+) A-I      intronic chr18:9387543(+) A-I      intronic chr18:9386296(+) A-I      intronic chr18:9386079(+) A-I      intronic chr18:9385933(+) A-I      intronic chr18:9385905(+) A-I      intronic chr18:9383421(+) A-I      intronic chr18:9383401(+) A-I      intronic chr18:9383392(+) A-I      intronic chr18:9383353(+) A-I      intronic chr18:9383293(+) A-I      intronic chr18:9382496(+) A-I      intronic chr18:9382436(+) A-I      intronic chr18:9382415(+) A-I      intronic chr18:9382378(+) A-I      intronic chr18:9382374(+) A-I      intronic chr18:9382371(+) A-I      intronic chr18:9382370(+) A-I      intronic chr18:9382365(+) A-I      intronic chr18:9378787(+) A-I      intronic chr18:9378723(+) A-I      intronic chr18:9377862(+) A-I      intronic chr18:9377853(+) A-I      intronic chr18:9377818(+) A-I      intronic chr18:9376732(+) A-I      intronic chr18:9376701(+) A-I      intronic chr18:9376687(+) A-I      intronic chr18:9376679(+) A-I      intronic chr18:9376677(+) A-I      intronic chr18:9376016(+) A-I      intronic chr18:9375987(+) A-I      intronic chr18:9375976(+) A-I      intronic chr18:9375117(+) A-I      intronic chr18:9375110(+) A-I      intronic chr18:9373409(+) A-I      intronic chr18:9371893(+) A-I      intronic chr18:9371484(+) A-I      intronic chr18:9371478(+) A-I      intronic chr18:9371469(+) A-I      intronic chr18:9371428(+) A-I      intronic chr18:9371424(+) A-I      intronic chr18:9371359(+) A-I      intronic chr18:9370241(+) A-I      intronic chr18:9370228(+) A-I      intronic chr18:9370218(+) A-I      intronic chr18:9370201(+) A-I      intronic chr18:9370160(+) A-I      intronic chr18:9370140(+) A-I      intronic chr18:9369803(+) A-I      intronic chr18:9369794(+) A-I      intronic chr18:9369776(+) A-I      intronic chr18:9369467(+) A-I      intronic chr18:9369450(+) A-I      intronic chr18:9369447(+) A-I      intronic chr18:9369408(+) A-I      intronic chr18:9369406(+) A-I      intronic chr18:9369393(+) A-I      intronic chr18:9369392(+) A-I      intronic chr18:9369360(+) A-I      intronic chr18:9369323(+) A-I      intronic chr18:9368986(+) A-I      intronic chr18:9368957(+) A-I      intronic chr18:9368770(+) A-I      intronic chr18:9368649(+) A-I      intronic chr18:9368633(+) A-I      intronic chr18:9368632(+) A-I      intronic chr18:9368338(+) A-I      intronic chr18:9367037(+) A-I      intronic chr18:9366007(+) A-I      intronic chr18:9366006(+) A-I      intronic chr18:9365737(+) A-I      intronic chr18:9365090(+) A-I      intronic chr18:9364719(+) A-I      intronic chr18:9349996(+) A-I      intronic chr18:9349901(+) A-I      intronic chr18:9370130(+) A-I      intronic chr18:9346536(+) A-I      intronic chr18:9373395(+) A-I      intronic chr18:9397002(+) A-I      intronic chr18:9398963(+) A-I      intronic chr18:9398961(+) A-I      intronic chr18:9398955(+) A-I      intronic chr18:9398951(+) A-I      intronic chr18:9398927(+) A-I      intronic chr18:9398921(+) A-I      intronic chr18:9344040(+) A-I      intronic chr18:9338942(+) A-I      intronic chr18:9339391(+) A-I      intronic chr18:9339465(+) A-I      intronic chr18:9339579(+) A-I      intronic chr18:9340216(+) A-I      intronic chr18:9340223(+) A-I      intronic chr18:9344038(+) A-I      intronic chr18:9373464(+) A-I      intronic chr18:9368635(+) A-I      intronic chr18:9365513(+) A-I      intronic chr18:9371567(+) A-I      intronic chr18:9385934(+) A-I      intronic chr18:9371939(+) A-I      intronic chr18:9369538(+) A-I      intronic chr18:9377946(+) A-I      intronic chr18:9339681(+) A-I      intronic chr18:9339504(+) A-I      intronic chr18:9375018(+) A-I      intronic chr18:9398886(+) A-I      intronic chr18:9376150(+) A-I      intronic chr18:9344885(+) A-I      intronic chr18:9368451(+) A-I      intronic chr18:9395613(+) A-I      intronic chr18:9371903(+) A-I      intronic chr18:9375993(+) A-I      intronic chr18:9370195(+) A-I      intronic chr18:9397868(+) A-I      intronic chr18:9382649(+) A-I      intronic chr18:9396910(+) A-I      intronic chr18:9367038(+) A-I      intronic chr18:9339015(+) A-I      intronic chr18:9365128(+) A-I      intronic chr18:9355161(+) A-I      intronic chr18:9370155(+) A-I      intronic chr18:9364533(+) A-I      intronic chr18:9376670(+) A-I      intronic chr18:9376680(+) A-I      intronic chr18:9368785(+) A-I      intronic chr18:9371905(+) A-I      intronic chr18:9393787(+) A-I      intronic chr18:9382297(+) A-I      intronic chr18:9384724(+) A-I      intronic chr18:9368586(+) A-I      intronic chr18:9371351(+) A-I      intronic chr18:9368629(+) A-I      intronic chr18:9377792(+) A-I      intronic chr18:9386203(+) A-I      intronic chr18:9369039(+) A-I      intronic chr18:9368381(+) A-I      intronic chr18:9344000(+) A-I      intronic chr18:9368786(+) A-I      intronic chr18:9368442(+) A-I      intronic chr18:9378852(+) A-I      intronic chr18:9368992(+) A-I      intronic chr18:9368655(+) A-I      intronic chr18:9369292(+) A-I      intronic chr18:9386377(+) A-I      intronic chr18:9368300(+) A-I      intronic chr18:9390811(+) A-I      intronic chr18:9382293(+) A-I      intronic chr18:9376079(+) A-I      intronic chr18:9367191(+) A-I      intronic chr18:9338977(+) A-I      intronic chr18:9378750(+) A-I      intronic chr18:9367055(+) A-I      intronic chr18:9390755(+) A-I      intronic chr18:9368925(+) A-I      intronic chr18:9369644(+) A-I      intronic chr18:9370169(+) A-I      intronic chr18:9367102(+) A-I      intronic chr18:9376177(+) A-I      intronic chr18:9346533(+) A-I      intronic chr18:9339580(+) A-I      intronic chr18:9368555(+) A-I      intronic chr18:9398637(+) A-I      intronic chr18:9383271(+) A-I      intronic chr18:9375958(+) A-I      intronic chr18:9398926(+) A-I      intronic chr18:9368303(+) A-I      intronic chr18:9376038(+) A-I      intronic chr18:9378736(+) A-I      intronic chr18:9383285(+) A-I      intronic chr18:9382793(+) A-I      intronic chr18:9368410(+) A-I      intronic chr18:9390517(+) A-I      intronic chr18:9344992(+) A-I      intronic chr18:9384748(+) A-I      intronic chr18:9368401(+) A-I      intronic chr18:9376167(+) A-I      intronic chr18:9365910(+) A-I      intronic chr18:9370065(+) A-I      intronic chr18:9373505(+) A-I      intronic chr18:9370056(+) A-I      intronic chr18:9344607(+) A-I      intronic chr18:9362395(+) A-I      intronic chr18:9365227(+) A-I      intronic chr18:9375013(+) A-I      intronic chr18:9376089(+) A-I      intronic chr18:9369320(+) A-I      intronic chr18:9368826(+) A-I      intronic chr18:9365154(+) A-I      intronic chr18:9382640(+) A-I      intronic chr18:9376709(+) A-I      intronic chr18:9369791(+) A-I      intronic chr18:9344879(+) A-I      intronic chr18:9398860(+) A-I      intronic chr18:9339566(+) A-I      intronic chr18:9390938(+) A-I      intronic chr18:9396945(+) A-I      intronic chr18:9377787(+) A-I      intronic chr18:9365133(+) A-I      intronic chr18:9364632(+) A-I      intronic chr18:9378858(+) A-I      intronic chr18:9375992(+) A-I      intronic chr18:9398842(+) A-I      intronic chr18:9376675(+) A-I      intronic chr18:9368340(+) A-I      intronic chr18:9376676(+) A-I      intronic chr18:9371948(+) A-I      intronic chr18:9339491(+) A-I      intronic chr18:9376052(+) A-I      intronic chr18:9364577(+) A-I      intronic chr18:9386299(+) A-I      intronic chr18:9398662(+) A-I      intronic chr18:9376095(+) A-I      intronic chr18:9386196(+) A-I      intronic chr18:9368807(+) A-I      intronic chr18:9365210(+) A-I      intronic chr18:9339424(+) A-I      intronic chr18:9390864(+) A-I      intronic chr18:9365650(+) A-I      intronic chr18:9376750(+) A-I      intronic chr18:9384668(+) A-I      intronic chr18:9369315(+) A-I      intronic chr18:9396977(+) A-I      intronic chr18:9364737(+) A-I      intronic chr18:9365261(+) A-I      intronic chr18:9344815(+) A-I      intronic chr18:9397072(+) A-I      intronic chr18:9369072(+) A-I      intronic chr18:9365280(+) A-I      intronic chr18:9340104(+) A-I      intronic chr18:9339503(+) A-I      intronic chr18:9345424(+) A-I      intronic chr18:9369477(+) A-I      intronic chr18:9355139(+) A-I      intronic chr18:9368712(+) A-I      intronic chr18:9365415(+) A-I      intronic chr18:9395775(+) A-I      intronic chr18:9377856(+) A-I      intronic chr18:9369790(+) A-I      intronic chr18:9366973(+) A-I      intronic chr18:9369768(+) A-I      intronic chr18:9371555(+) A-I      intronic chr18:9368799(+) A-I      intronic chr18:9365321(+) A-I      intronic chr18:9377811(+) A-I      intronic chr18:9369087(+) A-I      intronic chr18:9382400(+) A-I      intronic chr18:9386233(+) A-I      intronic chr18:9377749(+) A-I      intronic chr18:9376115(+) A-I      intronic chr18:9371314(+) A-I      intronic chr18:9369286(+) A-I      intronic chr18:9344887(+) A-I      intronic chr18:9371396(+) A-I      intronic chr18:9388737(+) A-I      intronic chr18:9344032(+) A-I      intronic chr18:9367127(+) A-I      intronic chr18:9368226(+) A-I      intronic chr18:9365174(+) A-I      intronic chr18:9367135(+) A-I      intronic chr18:9370079(+) A-I      intronic chr18:9368691(+) A-I      intronic chr18:9364672(+) A-I      intronic chr18:9368231(+) A-I      intronic chr18:9371954(+) A-I      intronic chr18:9376683(+) A-I      intronic chr18:9370107(+) A-I      intronic chr18:9386324(+) A-I      intronic chr18:9369057(+) A-I      intronic chr18:9393573(+) A-I      intronic chr18:9368926(+) A-I      intronic chr18:9376017(+) A-I      intronic chr18:9377978(+) A-I      intronic chr18:9339082(+) A-I      intronic chr18:9398851(+) A-I      intronic chr18:9368582(+) A-I      intronic chr18:9344093(+) A-I      intronic chr18:9385912(+) A-I      intronic chr18:9368690(+) A-I      intronic chr18:9368561(+) A-I      intronic chr18:9368390(+) A-I      intronic chr18:9368976(+) A-I      intronic chr18:9364727(+) A-I      intronic chr18:9367139(+) A-I      intronic chr18:9364601(+) A-I      intronic chr18:9377334(+) A-I      intronic chr18:9373307(+) A-I      intronic chr18:9398915(+) A-I      intronic chr18:9373288(+) A-I      intronic chr18:9370189(+) A-I      intronic chr18:9396936(+) A-I      intronic chr18:9369525(+) A-I      intronic chr18:9369764(+) A-I      intronic chr18:9398679(+) A-I      intronic chr18:9369367(+) A-I      intronic chr18:9370046(+) A-I      intronic chr18:9378715(+) A-I      intronic chr18:9384809(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TWSG1	chr18:9344879(+) A-I intron -    15258596 chr18:9344885(+) A-I intron -    15258596 chr18:9344887(+) A-I intron -    15258596 chr18:9375044(+) A-I intron -    22327324 chr18:9376115(+) A-I intron -    22327324 chr18:9383547(+) G-A intron -    22484847 chr18:9344000(+) A-G intron -    22484847 chr18:9365128(+) A-G intron -    22484847 chr18:9365158(+) A-G intron -    22484847 chr18:9368299(+) A-G intron -    22484847 chr18:9368300(+) A-G intron -    22484847 chr18:9371351(+) A-G intron -    22484847 chr18:9375018(+) A-G intron -    22484847 chr18:9375044(+) A-G intron -    22484847 chr18:9375992(+) A-G intron -    22484847 chr18:9375993(+) A-G intron -    22484847 chr18:9376017(+) A-G intron -    22484847 chr18:9376042(+) A-G intron -    22484847 chr18:9376052(+) A-G intron -    22484847 chr18:9376115(+) A-G intron -    22484847 chr18:9376709(+) A-G intron -    22484847 chr18:9376731(+) A-G intron -    22484847 chr18:9378852(+) A-G intron -    22484847 chr18:9378858(+) A-G intron -    22484847 chr18:9378873(+) A-G intron -    22484847 chr18:9386324(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TWSG1	chr18:9396347-9396348(+) m6A 3'UTR//CDS       24284625//24981863//26404942//22608085 chr18:9396403-9396404(+) m6A 3'UTR//CDS       24284625//24981863//26404942//22608085 chr18:9396431-9396432(+) m6A 3'UTR//CDS       24284625//24981863//26404942//22608085 chr18:9396468-9396469(+) m6A 3'UTR//CDS       24284625//24981863//26404942//22608085 chr18:9396475-9396476(+) m6A 3'UTR//CDS       24284625//24981863//26404942//22608085 chr18:9396610-9396611(+) m6A 3'UTR//intron       24284625 chr18:9396621-9396622(+) m6A 3'UTR//intron       24284625 chr18:9397045-9397046(+) m6A 3'UTR//intron       22608085 chr18:9399495-9399496(+) m6A 3'UTR//CDS       24284625//24981863//22608085 chr18:9399511-9399512(+) m6A 3'UTR//CDS       24284625//24981863//22608085 chr18:9399530-9399531(+) m6A 3'UTR       24284625//24981863//22608085 chr18:9399540-9399541(+) m6A 3'UTR       24981863//22608085 chr18:9399637-9399638(+) m6A 3'UTR       - chr18:9400369-9400370(+) m6A 3'UTR       22608085 chr18:9400391-9400392(+) m6A 3'UTR       22608085 chr18:9400451-9400452(+) m6A 3'UTR       24981863//22608085 chr18:9400456-9400457(+) m6A 3'UTR       24981863//22608085 chr18:9400477-9400478(+) m6A 3'UTR       24981863//22608085 chr18:9400511-9400512(+) m6A 3'UTR       24981863//22608085 chr18:9400544-9400545(+) m6A 3'UTR       24981863//22608085 chr18:9400549-9400550(+) m6A 3'UTR       24981863//22608085 chr18:9400582-9400583(+) m6A 3'UTR       24981863//22608085 chr18:9400587-9400588(+) m6A 3'UTR       24981863//22608085 chr18:9401336-9401337(+) Y 3'UTR       26075521

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-223-5p	Exosome Primary dendritic cells     21505438 Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	TWSG1	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|HeLa-S3 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-223-5p
Interactor2: TWSG1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.