Detail Information

Basic Information:


  VIRBase ID:  

HHID00065569

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-223-5p:           TMEM184C:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-223-5p TMEM184C
miRBase
Accession/Entrez ID		 MIMAT0004570 55751
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - TMEM34

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-223-5p
rs1240009384 chrX:66018913    A/T
rs1397275461 chrX:66018904    G/T
rs1464475149 chrX:66018916    T/C
rs761701581 chrX:66018906    C/G
rs772305537 chrX:66018909    G/A
rs774279244 chrX:66018895    C/T
rs890919635 chrX:66018896    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TMEM184C
chr4:148548618(+) A-I      intronic
chr4:148548567(+) A-I      intronic
chr4:148548546(+) A-I      intronic
chr4:148548535(+) A-I      intronic
chr4:148548521(+) A-I      intronic
chr4:148548490(+) A-I      intronic
chr4:148544575(+) A-I      intronic
chr4:148544573(+) A-I      intronic
chr4:148544556(+) A-I      intronic
chr4:148544436(+) A-I      intronic
chr4:148563002(+) A-I      intronic
chr4:148543966(+) A-I      intronic
chr4:148563051(+) A-I      intronic
chr4:148563490(+) A-I      intronic
chr4:148564234(+) A-I      intronic
chr4:148564227(+) A-I      intronic
chr4:148564172(+) A-I      intronic
chr4:148563575(+) A-I      intronic
chr4:148563502(+) A-I      intronic
chr4:148564235(+) A-I      intronic
chr4:148543936(+) A-I      intronic
chr4:148564240(+) A-I      intronic
chr4:148544422(+) A-I      intronic
chr4:148564344(+) A-I      intronic
chr4:148565014(+) A-I      intronic
chr4:148562917(+) A-I      intronic
chr4:148564359(+) A-I      intronic
chr4:148572132(+) A-I      intronic
chr4:148572142(+) A-I      intronic
chr4:148564364(+) A-I      intronic
chr4:148562939(+) A-I      intronic
chr4:148562942(+) A-I      intronic
chr4:148562979(+) A-I      intronic
chr4:148565000(+) A-I      intronic
chr4:148564996(+) A-I      intronic
chr4:148564967(+) A-I      intronic
chr4:148564960(+) A-I      intronic
chr4:148564888(+) A-I      intronic
chr4:148564367(+) A-I      intronic
chr4:148563027(+) A-I      intronic
chr4:148563035(+) A-I      intronic
chr4:148564338(+) A-I      intronic
chr4:148562913(+) A-I      intronic
chr4:148562111(+) A-I      intronic
chr4:148562925(+) A-I      intronic
chr4:148562103(+) A-I      intronic
chr4:148549235(+) A-I      intronic
chr4:148548748(+) A-I      intronic
chr4:148556061(+) A-I      3'UTR
chr4:148556017(+) A-I      3'UTR
chr4:148556019(+) A-I      3'UTR
chr4:148556058(+) A-I      3'UTR
chr4:148570793(+) A-I      intronic
chr4:148549254(+) A-I      intronic
chr4:148548495(+) A-I      intronic
chr4:148570710(+) A-I      intronic
chr4:148554631(+) A-I      intronic
chr4:148549199(+) A-I      intronic
chr4:148570843(+) A-I      intronic
chr4:148553312(+) A-I      intronic
chr4:148544876(+) A-I      intronic
chr4:148556007(+) A-I      3'UTR
chr4:148556135(+) A-I      3'UTR
chr4:148556134(+) A-I      3'UTR
chr4:148556147(+) A-I      3'UTR
chr4:148555893(+) A-I      3'UTR
chr4:148549036(+) A-I      intronic
chr4:148553075(+) A-I      intronic
chr4:148570779(+) A-I      intronic
chr4:148549289(+) A-I      intronic
chr4:148570728(+) A-I      intronic
chr4:148564161(+) A-I      intronic
chr4:148564964(+) A-I      intronic
chr4:148549167(+) A-I      intronic
chr4:148544017(+) A-I      intronic
chr4:148553076(+) A-I      intronic
chr4:148570930(+) A-I      intronic
chr4:148543222(+) A-I      intronic
chr4:148543258(+) A-I      intronic
chr4:148570876(+) A-I      intronic
chr4:148570771(+) A-I      intronic
chr4:148570718(+) A-I      intronic
chr4:148553308(+) A-I      intronic
chr4:148548635(+) A-I      intronic
chr4:148554657(+) A-I      intronic
chr4:148553191(+) A-I      intronic
chr4:148554563(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TMEM184C
chr4:148544876(+) A-G intron -    22484847
chr4:148548481(+) A-G intron -    22484847
chr4:148548545(+) A-G intron -    22484847
chr4:148549296(+) T-C intron -    22484847
chr4:148554657(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TMEM184C
chr4:148538709-148538710(+) m6A 5'UTR       -
chr4:148538714-148538715(+) m6A 5'UTR       22575960
chr4:148538944-148538945(+) m6A 5'UTR       24284625//24981863
chr4:148539027-148539028(+) m6A 5'UTR       24284625
chr4:148539038-148539039(+) m6A 5'UTR       24284625
chr4:148539105-148539106(+) m6A 5'UTR       24284625//24981863
chr4:148555380-148555381(+) m6A 3'UTR//CDS//intron       24284625//24981863//22608085
chr4:148555473-148555474(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr4:148555492-148555493(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr4:148555557-148555558(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr4:148555585-148555586(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr4:148555602-148555603(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr4:148555659-148555660(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22608085
chr4:148555774-148555775(+) m6A 3'UTR//intron       24981863//27773535//22608085
chr4:148555780-148555781(+) m6A 3'UTR//intron       24981863//27773535//22608085
chr4:148555823-148555824(+) m6A 3'UTR//intron       22608085
chr4:148555877-148555878(+) m6A 3'UTR//intron       22608085
chr4:148555894-148555895(+) m6A 3'UTR//intron       22608085
chr4:148556064-148556065(+) m6A 3'UTR//intron       24284625//24981863//22608085
chr4:148556180-148556181(+) m6A 3'UTR//intron       24284625//24209618//24981863//22608085
chr4:148556195-148556196(+) m6A 3'UTR//intron       24284625//24209618//24981863//22608085
chr4:148556279-148556280(+) m6A 3'UTR//intron       24284625//24981863//27773535//22608085
chr4:148556313-148556314(+) m6A 3'UTR//intron       24284625//24981863//27773535//22608085
chr4:148556844-148556845(+) m6A 3'UTR//intron       27773535
chr4:148556858-148556859(+) m6A 3'UTR//intron       27773535
chr4:148556864-148556865(+) m6A 3'UTR//intron       27773535
chr4:148556882-148556883(+) m6A 3'UTR//intron       27773535
chr4:148556922-148556923(+) m6A 3'UTR//intron       27773535
chr4:148557114-148557115(+) m6A 3'UTR//intron       24981863//22608085
chr4:148557122-148557123(+) m6A 3'UTR//intron       24981863//22608085
chr4:148557139-148557140(+) m6A 3'UTR//intron       24981863//22608085
chr4:148557266-148557267(+) m6A 3'UTR//intron       24981863//22608085
chr4:148557305-148557306(+) m6A 3'UTR//intron       24981863//22608085
chr4:148557347-148557348(+) m6A 3'UTR//intron       24981863//22608085
chr4:148557382-148557383(+) m6A 3'UTR//intron       24981863//22608085
chr4:148557397-148557398(+) m6A 3'UTR//intron       24981863//22608085
chr4:148557419-148557420(+) m6A 3'UTR//intron       24981863//22608085
chr4:148557440-148557441(+) m6A 3'UTR//intron       24981863//22608085
chr4:148557470-148557471(+) m6A 3'UTR//intron       24981863//22608085
chr4:148557500-148557501(+) m6A 3'UTR//intron       24981863//22608085
chr4:148557511-148557512(+) m6A 3'UTR//intron       24981863//22608085
chr4:148557527-148557528(+) m6A 3'UTR//intron       24981863//22608085
chr4:148557567-148557568(+) m6A 3'UTR//intron       24981863//22608085
chr4:148557587-148557588(+) m6A 3'UTR//intron       24981863//22608085
chr4:148557600-148557601(+) m6A 3'UTR//intron       24981863//22608085
chr4:148557613-148557614(+) m6A 3'UTR//intron       24284625//24981863//22608085
chr4:148557647-148557648(+) m6A 3'UTR//intron       24284625//24981863//22608085
chr4:148557660-148557661(+) m6A 3'UTR//intron       24284625//24981863//22608085
chr4:148557667-148557668(+) m6A 3'UTR//intron       24284625//24981863//22608085
chr4:148557680-148557681(+) m6A 3'UTR//intron       24284625//24981863//22608085
chr4:148557701-148557702(+) m6A 3'UTR//intron       24284625//24981863//22608085
chr4:148557758-148557759(+) m6A 3'UTR//intron       24981863//22608085
chr4:148557764-148557765(+) m6A 3'UTR//intron       24981863//22608085
chr4:148557783-148557784(+) m6A 3'UTR//intron       24981863//22608085
chr4:148557810-148557811(+) m6A 3'UTR//intron       24981863//22608085
chr4:148557827-148557828(+) m6A 3'UTR//intron       24981863//22608085
chr4:148593031-148593032(+) m6A 3'UTR       24981863//22608085
chr4:148593066-148593067(+) m6A 3'UTR       24981863//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-223-5p
Exosome Primary dendritic cells     21505438
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
TMEM184C
Chromatin K562 cells     -
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-223-5p
Interactor2: TMEM184C

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region CDS
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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