Basic Information:

  VIRBase ID:  

HHID00065567

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-223-5p:  MIMAT0004570          MAP7D1:  NM_001388490     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-223-5p	MAP7D1
miRBase Accession/Entrez ID	MIMAT0004570	55700
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	PARCC1//RPRC1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-223-5p	rs1240009384 chrX:66018913    A/T rs1397275461 chrX:66018904    G/T rs1464475149 chrX:66018916    T/C rs761701581 chrX:66018906    C/G rs772305537 chrX:66018909    G/A rs774279244 chrX:66018895    C/T rs890919635 chrX:66018896    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MAP7D1	chr1:36627464(+) A-I      intronic chr1:36643002(+) A-I      intronic chr1:36642994(+) A-I      intronic chr1:36629498(+) A-I      intronic chr1:36624848(+) A-I      intronic chr1:36624839(+) A-I      intronic chr1:36624833(+) A-I      intronic chr1:36635475(+) A-I      intronic chr1:36643046(+) A-I      intronic chr1:36624798(+) A-I      intronic chr1:36642645(+) A-I      intronic chr1:36634598(+) A-I      intronic chr1:36642678(+) A-I      intronic chr1:36637380(+) A-I      intronic chr1:36643003(+) A-I      intronic chr1:36626215(+) A-I      intronic chr1:36627153(+) A-I      intronic chr1:36635141(+) A-I      intronic chr1:36642986(+) A-I      intronic chr1:36642575(+) A-I      intronic chr1:36624919(+) A-I      intronic chr1:36634597(+) A-I      intronic chr1:36627073(+) A-I      intronic chr1:36643041(+) A-I      intronic chr1:36624842(+) A-I      intronic chr1:36637549(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MAP7D1	chr1:36642645(+) A-G intron -    22484847 chr1:36642986(+) A-G intron -    22484847 chr1:36643003(+) A-G intron -    22484847 chr1:36643041(+) A-G intron -    22484847 chr1:36643046(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MAP7D1	chr1:36621777-36621778(+) m6A 5'UTR//exon//intron       24209618//25456834//24981863 chr1:36621825-36621826(+) m6A 5'UTR//exon//intron       24284625//24209618//25456834 chr1:36621850-36621851(+) m6A 5'UTR//exon//intron       24284625//24209618//25456834 chr1:36621946-36621947(+) m6A 5'UTR//exon//intron       24209618 chr1:36621989-36621990(+) m6A 5'UTR//exon//intron       24209618 chr1:36621997-36621998(+) m6A 5'UTR//exon//intron       24209618 chr1:36636585-36636586(+) m6A 5'UTR//CDS//exon       24284625//24209618//24981863 chr1:36636602-36636603(+) m6A 5'UTR//CDS//exon       24284625//24209618//24981863//22575960 chr1:36636673-36636674(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960 chr1:36636725-36636726(+) m6A CDS//exon       24284625//24209618//25456834//24981863 chr1:36636809-36636810(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828 chr1:36636845-36636846(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828//22575960 chr1:36637121-36637122(+) m1A CDS//exon       26863196 chr1:36637135-36637136(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828 chr1:36637957-36637958(+) m6A exon//intron       - chr1:36638027-36638028(+) m6A exon//intron       24209618//25456834//24981863 chr1:36638223-36638224(+) m6A CDS//exon       24284625//24209618//24981863//26404942//22575960 chr1:36639000-36639001(+) m1A CDS//exon       26863196 chr1:36639068-36639069(+) m6A CDS//exon       24284625 chr1:36639075-36639076(+) m6A CDS//exon       24284625 chr1:36640538-36640539(+) m6A CDS//exon//intron       24284625 chr1:36640546-36640547(+) m6A CDS//exon//intron       24284625 chr1:36642315-36642316(+) m1A CDS//exon       26863196//26863410 chr1:36642319-36642320(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536 chr1:36643126-36643127(+) m6A exon//intron       24284625//24209618//25456834//24981863 chr1:36643149-36643150(+) m6A exon//intron       24284625//24209618//25456834//24981863 chr1:36643166-36643167(+) m6A exon//intron       24284625//24209618//25456834//24981863 chr1:36643667-36643668(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828 chr1:36643792-36643793(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828 chr1:36644074-36644075(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536 chr1:36644094-36644095(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536 chr1:36644103-36644104(+) m1A CDS//exon       26863196 chr1:36644193-36644194(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960 chr1:36644214-36644215(+) m6A exon//intron       24284625//24209618//25456834//24981863//27371828//27773536//22575960 chr1:36644245-36644246(+) m1A exon//intron       26863196//26863410 chr1:36644634-36644635(+) m6A exon//intron       24284625//24209618//25456834//24981863//27371828//22575960 chr1:36644705-36644706(+) m6A exon//intron       24284625//24209618//24981863 chr1:36644780-36644781(+) m6A exon//intron       24209618 chr1:36644858-36644859(+) m6A exon//intron       24209618//25456834 chr1:36644886-36644887(+) m6A CDS//exon       24209618//25456834 chr1:36644910-36644911(+) m6A CDS//exon       24209618//25456834 chr1:36645050-36645051(+) m6A exon//intron       24209618 chr1:36645122-36645123(+) m6A CDS//exon       24284625//24209618 chr1:36645561-36645562(+) m6A CDS//exon       24284625 chr1:36645572-36645573(+) m6A CDS//exon       24284625 chr1:36645589-36645590(+) m6A CDS//exon       24284625 chr1:36645598-36645599(+) m6A CDS//exon       24284625 chr1:36645936-36645937(+) m6A 3'UTR//exon       24284625 chr1:36645941-36645942(+) m6A 3'UTR//exon       24284625 chr1:36645944-36645945(+) Am 3'UTR//exon       - chr1:36646010-36646011(+) m6A 3'UTR//exon       24284625 chr1:36646074-36646075(+) m6A 3'UTR//exon       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-223-5p	Exosome Primary dendritic cells     21505438 Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	MAP7D1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-223-5p
Interactor2: MAP7D1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.