Detail Information

Basic Information:


  VIRBase ID:  

HHID00065566

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-223-5p:           RNF126:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-223-5p RNF126
miRBase
Accession/Entrez ID		 MIMAT0004570 55658
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - -

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-223-5p
rs1240009384 chrX:66018913    A/T
rs1397275461 chrX:66018904    G/T
rs1464475149 chrX:66018916    T/C
rs761701581 chrX:66018906    C/G
rs772305537 chrX:66018909    G/A
rs774279244 chrX:66018895    C/T
rs890919635 chrX:66018896    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR RNF126
chr19:660002(-) A-I      intronic
chr19:662153(-) A-I      intronic
chr19:659902(-) A-I      intronic
chr19:655127(-) A-I      intronic
chr19:648812(-) A-I      intronic
chr19:659888(-) A-I      intronic
chr19:662101(-) A-I      intronic
chr19:648857(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase RNF126
chr19:647590-647591(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr19:647603-647604(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr19:647608-647609(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr19:647637-647638(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr19:647986-647987(-) m6A 3'UTR//exon       24284625//24981863//27371828//27773536//22575960
chr19:648053-648054(-) m6A 3'UTR//exon       24284625//24981863//27371828//27773536//22575960
chr19:648221-648222(-) m6A 3'UTR//CDS//exon       24284625//27773535//22575960
chr19:648233-648234(-) m6A 3'UTR//CDS//exon       24284625//27773535//22575960
chr19:648238-648239(-) m6A 3'UTR//CDS//exon       24284625//27773535//22575960
chr19:648955-648956(-) m6A 3'UTR//CDS//exon       27773535
chr19:649078-649079(-) m6A exon//intron       27773535
chr19:649304-649305(-) m6A exon//intron       -
chr19:649721-649722(-) m6A 3'UTR//CDS//exon       27773536
chr19:649730-649731(-) m6A 3'UTR//CDS//exon       27773536
chr19:650365-650366(-) m6A exon//intron       27773536
chr19:651709-651710(-) m6A 3'UTR//CDS//exon       24284625//27773536//22575960
chr19:651733-651734(-) m6A 3'UTR//CDS//exon       24284625//27773536//22575960
chr19:651813-651814(-) m6A 3'UTR//CDS//exon//intron       24284625//27773536
chr19:651847-651848(-) m6A 3'UTR//CDS//exon//intron       24284625//27773536
chr19:651902-651903(-) m6A CDS//intron       24284625//27773536
chr19:652254-652255(-) m6A CDS//exon       24284625//27773536
chr19:652395-652396(-) m6A exon//intron       -
chr19:662838-662839(-) m6A intron       27773536
chr19:662861-662862(-) m6A intron       24209618//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-223-5p
Exosome Primary dendritic cells     21505438
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
RNF126
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleus HCC cell line (HepG2)     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-223-5p
Interactor2: RNF126

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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