Detail Information

Basic Information:


  VIRBase ID:  

HHID00065565

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-223-5p:           LRRC59:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-223-5p LRRC59
miRBase
Accession/Entrez ID		 MIMAT0004570 55379
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - p34//PRO1855

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-223-5p
rs1240009384 chrX:66018913    A/T
rs1397275461 chrX:66018904    G/T
rs1464475149 chrX:66018916    T/C
rs761701581 chrX:66018906    C/G
rs772305537 chrX:66018909    G/A
rs774279244 chrX:66018895    C/T
rs890919635 chrX:66018896    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR LRRC59
chr17:48461670(-) A-I      intronic
chr17:48471310(-) A-I      intronic
chr17:48461691(-) A-I      intronic
chr17:48461689(-) A-I      intronic
chr17:48461682(-) A-I      intronic
chr17:48461676(-) A-I      intronic
chr17:48461686(-) A-I      intronic
chr17:48461906(-) A-I      intronic
chr17:48461666(-) A-I      intronic
chr17:48461654(-) A-I      intronic
chr17:48461802(-) A-I      intronic
chr17:48461746(-) A-I      intronic
chr17:48461794(-) A-I      intronic
chr17:48461668(-) A-I      intronic
chr17:48461693(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED LRRC59
chr17:48461648(-) T-C intron -    22484847
chr17:48461693(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase LRRC59
chr17:48452516-48452517(-) m6A 3'UTR       22608085
chr17:48452529-48452530(-) m6A 3'UTR       22608085
chr17:48453088-48453089(-) m6A 3'UTR       22608085
chr17:48453182-48453183(-) m6A CDS       24284625//25456834//24981863//22608085
chr17:48458761-48458762(-) m6A 3'UTR//intron       24284625//27773535//22608085
chr17:48458793-48458794(-) m6A 3'UTR//intron       24284625//27773535//22608085
chr17:48458914-48458915(-) m6A 3'UTR//intron       24284625//24981863//27773535//22575960//22608085
chr17:48458951-48458952(-) m6A 3'UTR//intron       24284625//24981863//26404942//27773535//22575960//22608085
chr17:48458991-48458992(-) m6A 3'UTR//intron       24284625//24981863//26404942//22575960//22608085
chr17:48459050-48459051(-) m6A 3'UTR//intron       24284625
chr17:48459579-48459580(-) m6A 3'UTR//intron       26404942
chr17:48459594-48459595(-) m6A 3'UTR//intron       26404942
chr17:48459633-48459634(-) m6A 3'UTR//intron       26404942
chr17:48459639-48459640(-) m6A 3'UTR//intron       26404942
chr17:48459708-48459709(-) m6A 3'UTR//intron       26404942
chr17:48459757-48459758(-) m6A 3'UTR//intron       26404942
chr17:48459765-48459766(-) m6A 3'UTR//intron       22575960
chr17:48459801-48459802(-) m6A 3'UTR//intron       22575960
chr17:48459856-48459857(-) m6A 3'UTR//intron       26404942
chr17:48459890-48459891(-) m6A 3'UTR//intron       26404942
chr17:48459917-48459918(-) m6A 3'UTR//intron       -
chr17:48459923-48459924(-) m6A 3'UTR//intron       -
chr17:48459933-48459934(-) m6A 3'UTR//intron       -
chr17:48459975-48459976(-) m6A 3'UTR//intron       -
chr17:48460075-48460076(-) m6A 3'UTR//intron       24209618//24981863//27773535
chr17:48460198-48460199(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:48460214-48460215(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:48460256-48460257(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr17:48460279-48460280(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr17:48460365-48460366(-) m6A CDS//intron       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr17:48460430-48460431(-) m6A CDS//intron       24284625//27773535//27371828//22575960
chr17:48462506-48462507(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960
chr17:48462583-48462584(-) Gm CDS       -
chr17:48462596-48462597(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960
chr17:48462640-48462641(-) m1A CDS       26863196
chr17:48469762-48469763(-) m6A CDS       24284625//24209618//24981863//27773535//22575960
chr17:48469846-48469847(-) m6A CDS       27773535//22575960
chr17:48472304-48472305(-) m6A CDS       24284625//27773536
chr17:48473361-48473362(-) m6A 3'UTR//intron       24284625//27773536
chr17:48473383-48473384(-) m6A 3'UTR//intron       24284625//27773536
chr17:48473396-48473397(-) m6A 3'UTR//intron       24284625//27371828//27773536
chr17:48474616-48474617(-) m6A CDS       24284625//27371828//27773536//22575960
chr17:48474621-48474622(-) m6A CDS       24284625//27371828//27773536//22575960
chr17:48474649-48474650(-) m6A CDS       24284625//27371828//27773536//22575960
chr17:48474712-48474713(-) m6A 5'UTR       24284625//24209618//24981863//27371828//27773536//22575960//22608085
chr17:48474750-48474751(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr17:48474885-48474886(-) m6A 5'UTR       24209618//25456834//24981863//27371828//27773536//22575960//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-223-5p
Exosome Primary dendritic cells     21505438
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
LRRC59
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)|HeLa-S3 cells     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-223-5p
Interactor2: LRRC59

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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